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Principal Scientist / Director In vivo Pharmacology

 About Us

Our team is dedicated to the development of a broad pipeline of small molecules powered by unique chemistry insights to address a wide range of high unmet clinical needs.

 

Our company was created within 5AM Ventures' 4:59 Initiative in 2023. We are based in Watertown, MA with brand new, custom lab and office space underway!

 

What You'll Do

Provide strategic direction to the team, ensuring the integration of in vivo data with other research areas to drive drug development forward.

Design, oversee, and interpret in vivo efficacy studies conducted at established Contract Research Organizations (CROs) to assess the pharmacokinetics and pharmacodynamics of drug candidates.

Manage multiple projects simultaneously in a fast-paced environment, ensuring timely, accurate execution of studies that provide critical data for decision-making in the drug development process.

Leverage a deep understanding of translational biology to bridge preclinical research with clinical outcomes, applying biological principles to translate in vitro and in vivo data into actionable insights that guide clinical development. The ability to interpret and integrate data from diverse biological systems (e.g., animal models, human tissues) is crucial.

Collaborate with cross-functional teams (Chemistry, In Vitro Biology, Clinical Development) to design and develop preclinical and clinical models, providing insights into pharmacokinetics, pharmacodynamics, and overall efficacy of molecules as they progress through the drug development pipeline.

 

Key Responsibilities:

You'll plan, analyze, and interpret in vivo efficacy studies at established CROs to evaluate drug candidate performance.

Collaborate with cross-functional teams to understand molecular properties and design relevant in vivo models for preclinical evaluation.

Develop and optimize in vivo models that predict the behavior of molecules in biological systems, with a focus on pharmacokinetics, pharmacodynamics, and therapeutic efficacy.

Utilize state-of-the-art techniques in model design, data analysis, and interpretation to ensure the relevance and predictive power of in vivo studies.

Ensure integration of data across multiple disciplines (Chemistry, In Vitro Biology, Clinical Development) to inform decision-making and streamline drug development processes.

Provide data-driven insights that support the progression of molecules through the preclinical and clinical stages of development.

Troubleshoot experimental protocols and continuously optimize models based on results to improve study outcomes.

 

Who You Are

Earned your Ph.D. in Biology

You have at least 10 or more years of experience in biotech/pharmaceutical industry

Extensive knowledge of pharmacokinetics and pharmacodynamics.

Strong ability to collaborate and communicate effectively across multidisciplinary teams.

Proven experience managing in vivo studies at CROs, with a solid track record of successful project execution.

Extensive experience in in vivo model development and biological testing across various therapeutic areas.

Ability to integrate complex data sets to inform drug development strategies.

Your colleagues would describe you as an open and articulate communicator.

You bring an openness to learn from diverse perspectives and collaborate on multidisciplinary teams.

You have a track record of scientific rigor and creativity in carrying out research 


 


 

We are an equal opportunity employer. We do not discriminate in regard to race, color, religion, national origin, age, sex, sexual orientation, gender identity, marital status, ancestry, physical or mental disability, veteran status, or any other legally protected characteristics.

 

 

Please note that we do not accept unsolicited resumes from recruitment agencies and external recruiters. No fees will be paid for such submissions.

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Average salary estimate

$145000 / YEARLY (est.)
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$130000K
$160000K

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Full-time, on-site
DATE POSTED
January 12, 2025

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