Associate Scientist, Product Sciences - job 1 of 2

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

The Cell Therapy Development and Operations (CTDO) Organization is seeking a Scientist to support the development and lifecycle management (LCM) of middle-stage (i.e. post Phase 1), late-stage, and/or commercial autologous cell therapy products. CTDO is responsible for developing and executing mechanism of action and characterization studies to support the development of autologous CAR T cell therapies.
 

Position Summary

The primary focus of the Associate Scientist role will be lab-based activities (i.e., building analytical and/or process capabilities) to build T cell product and process understanding in support of CAR T products with a particular focus on investigational needs in support of middle/late-stage clinical CMC development, process automation, manufacturing success, and robust product/process control strategies. Successful candidates will have a very strong foundation in cell-based assays (flow cytometry, proliferation, cytotoxicity, cytokine release, etc.) and some background in human T cell biology and/or other immune cell types. Experience with implementation and optimization of a broad range of in vitro cell-based and molecular assays is critical (especially multi-color flow cytometry and cell culture).  This role is highly collaborative and requires attention to detail, a healthy sense of urgency, a strong desire to learn, and a passion for exploratory and investigational science. Furthermore, a demonstrated ability to support cross-functional teams and independently design and execute studies to meet project goals is desirable (albeit not a requirement and will depend on the applicant’s individual qualifications).    

Key Responsibilities

The primarily focus of this role is to support middle/late-stage and/or commercial drug product and manufacturing process understanding by performing characterization studies and investigational analyses including experimental design and execution, statistical/correlative analyses of existing data sets, writing technical reports, presenting data, etc. Additionally, depending on the applicant’s individual qualifications, duties and responsibilities include the following:

• Execute characterization of T cell and/or other immune cells using flow cytometry, genome-wide expression analysis, metabolic profiling, and/or additional cutting-edge analytical techniques, as necessary to support manufacturing and Scientific CMC strategies.

• Analyze, interpret, and report experimental results to support conclusions and next steps.

• Optimize and execute assays, manage instruments and reagents, monitor assay performance, and troubleshoot.

• Serve as analytical method SME.

• Develop and maintain relationships with external collaborators and service providers.

• Author, review, and approve technical documents, including methods, protocols, reports, and SOPs.

• Serve as T cell biology subject matter expert in multidisciplinary team setting, that includes non-clinical, clinical, regulatory, and CMC functions; and participate in cross-functional teams to support the advancement and manufacture of gene engineered T cell therapeutic platforms.

Qualifications & Experience

Required Qualifications and Education Requirements:

• Extensive experience with standard and next generation analytical platforms for the characterization of T cell phenotype, differentiation, and function [Multi-color Flow Cytometry (BD Symphony, BD A5); Spectral Flow Cytometry (Cytek Aurora); Proliferation (CellTrace, Incucyte); Cytotoxicity (Calcein, LDH, Incucyte); Cytokine Release (Luminex, MSD, Intracellular Staining)] and process/enrichment platforms (e.g., CliniMACs, TYTO, RoboSep, EasySep).

• Experience with data visualization and analysis software (JMP, EXCEL, etc.) and/or coding-based analysis (R, Python, etc.)

• Proven ability to collaborate in a fast-paced environment, meet deadlines, and prioritize work on multiple projects.

• Attention to detail and excellent interpersonal, written, and verbal communication skills

Preferred Qualifications:

• Demonstrated independence in experimental design, data analysis, interpretation, and presentation.

• Demonstrated experience with CAR-T products and scale-down models for CAR-T cell processing and production.

• Expertise in human T cell biology and in vitro characterization of T cell differentiation and function.

The starting compensation for this job is a range from $82,000 - $102,000,

plus incentive cash and stock opportunities (based on eligibility). The starting pay rate takes into account characteristics of the job, such as required skills and the geographic location where work is performed. Final, individual compensation is decided commensurate with demonstrated experience. For more on benefits, please visit our BMS Careers Site. Eligibility for specific benefits listed therein may vary based on job and location.

Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown Days between Christmas and New Year’s holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program.

If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/

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