We are currently looking to hire a Bioinformatician / Computational Biologist to analyze and mine genome-wide next generation sequencing datasets (such as single cell and bulk RNAseq data, ATAC-seq data, etc) to gain insights into stem cell & ovarian cell biology. You will collaborate closely with a group of talented bioinformaticians to deliver scientific results and data visualizations, as well as with bench scientists to analyze ‘omics data for a broad range of projects. Routine work includes running and maintaining automated bioinformatics pipelines, which include QC assessments, differential expression and data visualization components. Understanding how to interpret complex low input datasets for biological utility and translate findings back to the bench is a key requirement. You will collaborate broadly with biologists to identify ways in which to leverage our computational data towards new hypotheses and scientific directions that can then be tested in the lab. Your work would include many opportunities to find custom solutions to interesting biological problems.
Our mission
Conception is a startup with the mission of generating viable human eggs from induced pluripotent stem cells (iPSCs). Successful development of our research could have many benefits, such as removing age limits on motherhood, allowing for easy screening of eggs with harmful genetic mutations, and allowing same-sex couples to reproduce. This has been done in mice, and now we are working to translate it to humans.
Our research
To accomplish our goal, we must derive human germ cells from iPSCs (human germ cell-like cells, hPGCLCs) that resemble both the transcriptional and epigenetic profile of in vivo germ cells (PGCs) that are able to enter meiosis and develop to viable human eggs. We create ovarian organoids from primary cells and stem cell derived cells to help the eggs develop properly.
Tasks & responsibilities:
Functionally interact with core Conception computational infrastructure including databases, automated pipelines, HPC cluster, etc
Contribute to team code bases, using best practices for documentation and version control
Work with biology teams to independently perform team-specific analysis projects using both in-house & publicly available data
Required skills/experience:
PhD in computational biology, genomics, systems biology or related field or masters + 1-3 years of industry experience.
Highly proficient in R, python, and bash
Highly proficient in analyzing RNA-seq data, including experience with single cell RNAseq packages/workflows/algorithms.
Excellent foundational data analysis skills (understand how to clean/QC data, grasp of basic statistical principles, generate hypotheses and 'smell test' data before returning a result)
Highly proficient in building and running automated preprocessing workflows for a variety of data types including (sc)RNAseq or ATAC-seq
Proficiency in versioning and collaborative coding via git
Strong ability to devise, scope, and execute data analyses independently
Prior experience translating computational findings into testable hypotheses and experimental designs
Strong communication skills, particularly with diverse audiences
Prior experience with a high performance computing cluster and/or cloud computing environment
Preferred skills/experience:
Prior experience with iPSC derivation & germ cell biology preferred
Knowledge of relevant bench techniques is beneficial
Experience with spatial transcriptomics
Come and work with us
We are well-funded and connected in Silicon Valley, offering competitive pay, equity, excellent healthcare benefits, and a collaborative research environment focused on meaningful results.
If you are passionate, hardworking, and aligned with our mission, we want to hear from you!
To learn more about us, our mission, and approach you can read two features published by The New Yorker and MIT Technology Review.
#LI-AS1
If an employer mentions a salary or salary range on their job, we display it as an "Employer Estimate". If a job has no salary data, Rise displays an estimate if available.
Eurofins Scientific seeks a detail-focused Entry Level QC Analytical Chemist to perform GMP-compliant pharmaceutical testing onsite in Andover, MA.
Explore cutting-edge AI innovations and drive technology scouting at EX Venture's immersive Bali internship program.
Pickle is looking for an Applied AI Engineer to pioneer multimodal AI research that enables highly realistic, human-like digital clones.
Gridmatic is seeking a skilled Atmospheric Engineer to enhance weather modeling capabilities and contribute to energy forecasting innovations in a dynamic startup environment.
Drive innovation in automated antivirus signature generation at Palo Alto Networks as a Senior Security Researcher specializing in malware and antivirus system development.
Bristol Myers Squibb is seeking a Clinical Scientist to lead early clinical development trials and contribute to impactful life-changing therapies.
Participate in Susquehanna's hands-on Quantitative Strategy Developer Summer Internship, combining trading desk work with deep financial markets education.
Seeking a Research Technician with analytical chemistry expertise to support R&D efforts at Eurofins Scientific's Boston laboratory.
Experienced Architectural Engineers are sought to collaborate with AI teams remotely at RYZ Labs to help train advanced AI models in architectural-engineering expertise.
A Scientific Director role at AbbVie leading international medical affairs in Gastroenterology to drive scientific strategy, medical education, and cross-functional collaboration.
Experienced intelligence professional needed to lead systems integration and user adoption efforts for a DoD program in a remote role with travel.
Advance cancer early detection research as a Postdoctoral Scholar at OHSU by developing innovative biomaterials and biofabrication techniques within an interdisciplinary team.
KBR is seeking a Research Engineer to perform critical defense research and analysis in support of AFIT and U.S. national security missions.
Subscribe to Rise newsletter