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Senior Scientist, Physical Chemistry II

Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on XFacebookInstagramYouTubeLinkedIn and Tik Tok.

Job Description

AbbVie is looking for a talented scientist with strong expertise in the biophysical characterization of peptides to join our team in Lake County, Illinois. This scientist, using NMR spectroscopy, computational methods, and other biophysical tools, will play a central role in the discovery and advancement of peptide-based therapeutics across a variety of disease areas. As an integral member of our team, you will drive projects and collaborate across various functions within our Discovery organization. Initial efforts will involve the development of robust workflows aimed at conformational evaluation of peptides, both free in solution, and when bound to a target protein. Success in this position requires a solid foundation in NMR spectroscopy and related computational methods, strong collaborative skills, and excellent communication skills. This role will require a high level of technical proficiency combined with a proactive approach to solving key problems and answering key questions related to peptide-based drug discovery.

Key Responsibilities:

  • Develop NMR experimental and computational workflows aimed at peptide resonance assignment and the determination of both free and protein-bound peptide conformations
  • Integrate these workflows into overall efforts aimed at discovering and advancing peptide-based therapeutics
  • Serve as a technical expert with respect to peptide biophysical analysis, especially NMR
  • Work closely with project teams to identify and solve key questions within the domain of peptide-based drug discovery
  • Stay ahead of scientific discoveries to integrate valuable insights into evolving strategies for peptide-based drug discovery especially with respect to biophysical analysis

Qualifications

  • Ph.D. in Biophysics, or a related field, with at least 2 years of relevant experience in academia or industry
  • Solid expertise in the use of NMR spectroscopy to characterize peptides, especially, NMR resonance assignment and structure determination is a must
  • Proficiency in programming and the use of computational tools as applied to peptide characterization is a must
  • Experience with other biophysical methods would be a plus
  • Knowledge of peptide synthetic methodologies would be a plus
  • Excellent organizational and time-management skills, coupled with an independent and detail-oriented approach to problem-solving
  • Outstanding collaborative skills with the ability to work as part of a cross-functional team
  • Excellent communication skills, adaptable to a variety of audiences, both technical and non-technical

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​

  • The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.​
  • We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​
  • This job is eligible to participate in our short-term incentive programs. ​
  • This job is eligible to participate in our long-term incentive programs​

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. ​

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion.  It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.

US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html 

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:

https://www.abbvie.com/join-us/reasonable-accommodations.html

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Average salary estimate

$100000 / YEARLY (est.)
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$80000K
$120000K

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What You Should Know About Senior Scientist, Physical Chemistry II, AbbVie

AbbVie is thrilled to announce we are on the lookout for a Senior Scientist, Physical Chemistry II to join our dynamic team in North Chicago, IL. If you are passionate about peptide-based therapeutics and have a strong background in biophysical characterization, this could be the opportunity for you! In this role, you will leverage cutting-edge tools like NMR spectroscopy and computational methods to drive the discovery and advancement of innovative treatments across various disease areas. Your day-to-day will involve the development of robust workflows for conformational evaluation, working closely with cross-functional teams to resolve key questions in peptide-based drug discovery. Engaging in this collaborative environment requires not only technical skills but also excellent communication abilities to share insights with both technical and non-technical audiences. If you have a Ph.D. in Biophysics or a related field with at least two years of relevant experience, a solid grasp of NMR spectroscopy, and a proactive attitude toward problem-solving, we want to hear from you! Your expertise will help us integrate the latest scientific discoveries into our strategies for peptide drug development. Join AbbVie and be a part of a team that truly makes a difference in people's lives!

Frequently Asked Questions (FAQs) for Senior Scientist, Physical Chemistry II Role at AbbVie
What qualifications are needed to become a Senior Scientist, Physical Chemistry II at AbbVie?

To become a Senior Scientist, Physical Chemistry II at AbbVie, candidates should possess a Ph.D. in Biophysics or a related field, with a minimum of two years of relevant experience in either academia or industry. Expertise in NMR spectroscopy for peptide characterization is essential, along with proficiency in computational methods applied to peptide analysis. Additional skills in biophysical methods and knowledge of synthetic methodologies will be advantageous.

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What are the key responsibilities of a Senior Scientist, Physical Chemistry II at AbbVie?

In the role of Senior Scientist, Physical Chemistry II at AbbVie, key responsibilities include developing NMR experimental workflows for peptide resonance assignments and the conformation evaluation of peptides, both in solution and when bound to target proteins. You will drive projects related to peptide drug discovery and collaborate with various cross-functional teams to address key scientific questions.

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How does a Senior Scientist, Physical Chemistry II contribute to peptide-based drug discovery at AbbVie?

A Senior Scientist, Physical Chemistry II at AbbVie plays a crucial role in advancing peptide-based therapeutics by utilizing biophysical tools such as NMR spectroscopy. This scientist integrates advanced workflows to evaluate conformational data and works collaboratively with other team members to address scientific challenges, ultimately contributing to the drug development process.

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What skills are necessary for success as a Senior Scientist, Physical Chemistry II at AbbVie?

Success in the Senior Scientist, Physical Chemistry II position at AbbVie hinges on strong technical skills in NMR spectroscopy and computational methods, coupled with outstanding collaboration and communication abilities. The role demands a proactive approach to problem-solving and the capacity to adapt insights from current scientific discoveries into practical applications within drug discovery.

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What kind of work environment can I expect as a Senior Scientist, Physical Chemistry II at AbbVie?

As a Senior Scientist, Physical Chemistry II at AbbVie, you can expect to work in a collaborative and innovative environment that emphasizes teamwork across various functions. The position offers opportunities for professional growth and development, allowing you to make significant contributions to impactful projects in peptide-based therapies.

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Common Interview Questions for Senior Scientist, Physical Chemistry II
Can you explain your experience with NMR spectroscopy in peptide characterization?

In answering this question, focus on specific techniques you've employed in NMR spectroscopy, including resonance assignment and structure determination. Discuss relevant projects where you successfully utilized these methods and how they contributed to your understanding of peptide characteristics.

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Describe a challenging problem you faced in drug discovery and how you resolved it.

Provide a specific example from your previous work where you encountered a significant challenge in the drug discovery process. Outline the steps you took to evaluate and overcome the issue, highlighting your analytical thinking and teamwork approach.

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What programming languages and computational tools are you familiar with for peptide analysis?

Discuss any programming languages such as Python or R that you have used in your work, and explain how you leveraged computational tools to support peptide characterization. Provide examples of how these tools enhanced your research outcomes.

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How do you stay updated with advancements in biophysical analysis techniques?

Mention specific journals, conferences, or workshops you engage with to keep current in the field. Explain how you apply new findings or techniques to your projects and why staying informed is crucial for drug discovery.

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Can you share an experience where you collaborated with a cross-functional team?

Highlight a specific project where teamwork was essential. Describe your role, the contributions of other disciplines, and how the collaborative effort led to a successful project outcome.

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How would you design an experimental workflow for a new peptide project?

Explain your thought process for developing a workflow, from initial hypothesis to experimental design. Include aspects like NMR experimental setup, data analysis techniques, and how you would integrate feedback from team members.

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What qualities do you think are essential for a Senior Scientist at AbbVie?

Discuss the importance of technical proficiency, effective communication, and collaboration. Emphasize that the role requires adaptability and a proactive attitude toward problem-solving.

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Describe your experience with biophysical methods other than NMR.

Share knowledge of any additional biophysical techniques you've used, such as circular dichroism or fluorescence spectroscopy. Highlight how these methods complemented your work in peptide characterization.

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What motivates you to work in the field of peptide-based therapeutics?

Reflect on your passion for advancing medical science, the potential to impact patient lives, or specific experiences that inspired you to pursue this field. Convey enthusiasm about the scientific challenges and opportunities.

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How do you prioritize your workload when faced with multiple projects?

Explain your method for managing time and prioritizing tasks, such as using project timelines, setting deadlines, and communicating with team members to ensure alignment on goals and deliverables.

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AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: i...

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DATE POSTED
March 20, 2025

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