Associate Director/Director, In vivo Pharmacology

Position - Associate Director/Director In vivo Pharmacology

Mission Statement

Through single-cell biology, computational biology, and artificial intelligence, Immunai is reprogramming the immune system to develop improved drugs and therapeutics.

Background

Immunai was founded in December 2018. We are a multidisciplinary team of immunologists, genomics technologists, computer scientists, engineers, mathematicians and operators singularly focused on solving an audacious challenge. Backed by some of the leading scientific minds in immunology, oncology, and single cell genomics, we are up for the challenge.

Immunai has begun the process of mapping millions of immune cells and their functions in order to build a proprietary data set for clinical immunological data. The immune system mapping will play an important role in boosting R&D efforts in developing targeted therapies for different diseases. The company noted that the immune system consists of trillions of cells that are divided into different cell types that perform different functions. Because of the complexity of the system, it can be difficult to determine how drugs will interact with the immune cells. This increased understanding can be used to boost clinical response to different cellular therapies.

Immunai’s mission is to map the immune system with neural networks and transfer learning techniques informed by deep immunology knowledge. We developed the tools and knowhow to help every immuno-oncology and cell therapy researcher excel at their job. This helps increase the speed in which drugs are developed and brought to market by elucidating their mechanisms of action and resistance.

Location - New York City

For details - www.immunai.com, info@immunai.com

Responsibilities

• Coordinate in vivo studies to evaluate drug targets and drug candidates, focused primarily on biologics, in mouse models of oncology and inflammation.
• Be the primary point of contact with initiating, managing and analyzing data for in vivo studies conducted primarily at external CROs and in some cases through internal vivarium use
• Interface with disease biology teams to coordinate evaluation of candidate therapeutics in in vivo studies
• Interface with disease biology teams to design experiments in appropriate disease models and PK/PD models for drug candidate evaluation
• Coordinate with protein engineering team to evaluate PK/PD of candidate therapeutics and optimize drug candidate selection
• Develop robust data packages, author accompanying reports to support regulatory filings

Qualifications

• Ph.D. in Immunology, Cancer Biology or related field with 5+ years of post-graduate experience or M.S. in Immunology, Cancer Biology or related field with 7+ years of post-graduate experience, including 4 or more at high-growth biotechnology or pharmaceutical companies
• Experience with mouse models of oncology and inflammation
• Expertise in in vivo experimental design and execution, including tissue harvesting and downstream analysis of immune cells by flow cytometry and gene expression
• Familiar with preclinical drug development processes
• Adept in ambiguous situations, flexible and comfortable making decisions using minimal available data
• A proven ability to work cross-functionally and adapt to changing priorities while managing multiple commitments with accuracy and efficiency to meet deadlines
• Strong organizational skills, attention to detail, ability to prioritize and meet deadlines in a fast-paced and multi-cultural environment

Desired Personal traits

• You want to make an impact on humankind
• You prioritize “We” over “I”
• You enjoy getting things done - with super high quality
• You collaborate effectively with people of diverse backgrounds and cultures
• You have superior skills and experience, and constantly strive to be world-class in what you do
• You constantly challenge your own assumptions, pushing for continuous improvement
• You have a growth mindset
• You make decisions that favor the company, not yourself or your team
• You are candid, authentic, and transparent