Associate Scientist / Scientist, Biomarkers

The Biomarker team of Quantitative Translational ADME Science (QTAS) at AbbVie in Worcester, MA is seeking a creative, experienced, and highly motivated scientist to develop bioanalytical biomarker methods and analyze preclinical/clinical samples to support the discovery and development of novel therapies in multiple therapeutic areas. The ideal candidate should have hands-on experience in a variety of technologies, including but not limited to ligand binding assays, quantitative PCR, pre-analytics (sample processing steps), etc. He/she will be a key member of a global biomarker bioanalysis team supporting all AbbVie therapeutic areas with fit-for-purpose methods to enable discovery and development stage decision-making.

Responsibilities

• Develop, validate, transfer, and troubleshoot robust ligand binding biomarker assays on multiple analytical platforms across a variety of sample matrices
• Conduct and document appropriately compliant biomarker sample testing to support non-clinical and clinical studies.
• Develop effective partnerships with discovery, preclinical safety, clinical pharmacology, and project team representatives in a culture of collaboration and innovation to ensure timely delivery of high-impact data.
• Evaluate novel, pipeline-enabling assay technologies to expand capabilities and enhance efficiency.
• Maintain laboratory notebooks in compliance with AbbVie policies.

Qualifications:

Job level will be commensurate with experience.

• Bachelor’s Degree or Masters Degree in Chemistry, Biology, Immunology, or related field required.
  • Associate Scientist requires a minimum of 3 years of relevant experience (with a Bachelor's degree) or a Master's degree.
  • Scientist requires a minimum of 5 years (with a Bachelor's degree) or a minimum of 2 years (with a Master's degree) of relevant experience.
• Working knowledge of Ligand-binding assay (ELISA, MSD, etc.) development, validation, and sample testing workflows to comply with current regulatory standards and best industry practices.
• Working knowledge in Molecular Biology, especially in DNA/RNA purification and quantitative PCR (qPCR).
• Familiarity with PK/TK and immunogenicity bioanalytical method development and sample testing approaches is a plus.
• Excellent communication skills, and proven ability to work effectively as a member of a multidisciplinary team.
• Working knowledge of Good Laboratory Practices (GLP), Good Clinical Practices (GCP), and GCLP compliance models is a plus.
• Demonstrated capacity to work in a fast-paced environment with meticulous attention to detail, and an ability to handle multiple projects, prioritize work, and meet deadlines.
• Working knowledge of Watson LIMS system is a plus.

AbbVie is an equal opportunity employer including disability/vets. It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a disabled veteran, recently separated veteran, Armed Forces service medal veteran or active duty wartime or campaign badge veteran or a person’s relationship or association with a protected veteran, including spouses and other family members, or any other protected group status. We will take affirmative action to employ and advance in employment qualified minorities, women, individuals with a disability, disabled veterans, recently separated veterans, Armed Forces service medal veterans or active-duty wartime or campaign badge veterans. The Affirmative Action Plan is available for viewing in the Human Resources office during regular business hours.