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Postdoctoral Fellow – Treg Cell Therapy

Introduction

Do you have expertise and passion for immunology and cell therapies? Would you like to be part of a cross-functional team driving the discovery of next-generation Treg cell therapies for treating autoimmune diseases in a company that follows the science and turns ideas into life-changing medicines? Then join the Cell Therapeutics and Engineering group within the Biologics Engineering department, and the Bioscience Immunology group within the Early Respiratory and Immunology department at AstraZeneca. Unlock the power of what science can do.

About the Opportunity

This is an exciting opportunity for you, an outstanding and ambitious cell and molecular biologist with experience in immunology, T cell biology, or cell therapies, to join the Cell Therapeutics and Engineering group. Your focus will be on researching and developing next-generation Treg Cell therapies. A major focus of the Treg Therapy team is to apply Tregs or CAR-Tregs as a modality to treat human inflammation-related diseases like autoimmunity, organ transplantation, and GvHD. You will work closely with colleagues specializing in Treg cell biology, autoimmunity, gene editing, multi-omics, high-throughput screening technologies, and cell product manufacturing across AstraZeneca sites.

Project Focus

We seek a proactive and dedicated individual like you to research and develop new engineering strategies to improve the efficacy of Treg/CAR-Treg cell therapy. You will publish results in high-impact journals.

Professional Growth

We will empower you to take appropriate risks, lead your project, and "run with it," while providing all the support you need. You will work in an industry-leading group with a strong publication track record.

What You’ll Do

As part of this journey, you will drive the discovery of novel biology and engineering strategies to solve current challenges in Treg cell therapies. Through discussions with industrial and academic supervisors, you will lead innovative research to improve the efficacy and tissue specificity of Treg/CAR-Treg cell therapies. You will also have the opportunity to generate biological and translational insights and publish your research in high-impact journals, sharing your findings at conferences both nationally and internationally.

Key Duties & Responsibilities

  • Lead projects focused on the research and development of next-generation Treg/CAR-Treg cell therapy-related technologies, including engineering and in vitro and in vivo validation assays.
  • Collaborate with experts in immunology, T/Treg cell biology, autoimmunity, gene editing, and multi-omics technologies across AstraZeneca.
  • Share your research with the academic and industrial community by presenting at meetings and conferences and writing up your work for publication in high-impact journals.

Essential Requirements

  • PhD in immunology, cell biology, molecular biology, or another relevant field.
  • Experience with in vitro cell culture assays, including cancer cell lines and primary T cells.
  • Experience with molecular and cellular biology techniques, including DNA cloning, flow cytometry, ELISA, RT-qPCR, and Western blotting.
  • Strong track record of first-authored work published in reputable scientific journals.

Desirable Requirements

  • Sound understanding of immunology, cell biology, and molecular biology.
  • Experience with molecular cloning, mammalian cell culture, qPCR, multi-panel flow cytometry, NGS, and proteomics analysis.
  • Detailed understanding of cell-based assay technologies and their application in the characterization of biologics, such as assays used for cytotoxicity, cellular signaling, cytokine secretion, and cell proliferation.
  • Experience with in vivo experiments using autoimmune disease animal models.
  • Excellent communication skills (oral and written).

At AstraZeneca, you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There is no better place to make a difference in medicine, patients, and society. We champion an inclusive culture that values diversity, collaboration, and are committed to lifelong learning, growth, and development, pioneering the future of healthcare.

Stages of the Interview

Applications are reviewed for fit/skills, and you may be invited to each step:

1. One-way video interview

2. Virtual interview panel with presentation

To find out more, visit astrazeneca.com. We anticipate a high volume of applicants, so do not delay in applying today!

Compensation for this role, depending on years of research experience, ranges from a minimum of $96,000 to $104,000, plus a short-term incentive. Some relocation supplements depend on distance and location at the employer's discretion.

Date Posted

16-Apr-2025

Closing Date

15-Apr-2025Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.
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Average salary estimate

$100000 / YEARLY (est.)
min
max
$96000K
$104000K

If an employer mentions a salary or salary range on their job, we display it as an "Employer Estimate". If a job has no salary data, Rise displays an estimate if available.

What You Should Know About Postdoctoral Fellow – Treg Cell Therapy, AstraZeneca

Join AstraZeneca as a Postdoctoral Fellow in Treg Cell Therapy and dive into the exciting world of immunology and cell therapies! Based in Gaithersburg, MD, you will play a pivotal role in a cross-functional team dedicated to developing next-generation Treg cell therapies aimed at treating autoimmune diseases. This position is ideal for ambitious cell and molecular biologists passionate about leveraging their expertise in T cell biology and immunology. Your work will focus on researching innovative strategies to enhance Treg and CAR-Treg therapies, collaborating with leading experts in gene editing, multi-omics technologies, and cell product manufacturing. You will have the unique opportunity to not only lead crucial projects but also publish your groundbreaking findings in high-impact journals. At AstraZeneca, you’ll be empowered to take informed risks and drive your research forward while being part of an organization committed to life-changing discoveries. Here, your contributions will matter not just within the company but also to the broader scientific community. Whether presenting at national and international conferences or working alongside seasoned professionals, this is where you can truly make a difference in medicine and patient care. Your PhD in cell biology, molecular biology, or a related field along with hands-on experience in cell culture assays and molecular techniques will set you up for success in this dynamic role. Join us at AstraZeneca, where the future of healthcare is built upon innovative thinking and a collaborative spirit. Apply today to take the next step in your career!

Frequently Asked Questions (FAQs) for Postdoctoral Fellow – Treg Cell Therapy Role at AstraZeneca
What are the responsibilities of a Postdoctoral Fellow in Treg Cell Therapy at AstraZeneca?

As a Postdoctoral Fellow in Treg Cell Therapy at AstraZeneca, your primary responsibilities will involve researching and developing innovative strategies aimed at enhancing the efficacy of Treg and CAR-Treg cell therapies. You will lead projects that include in vitro and in vivo validation assays, and collaborate with experienced scientists in immunology and related fields to share findings and insights. Your work will also include publishing research results in high-impact journals and presenting at conferences, playing a vital role in advancing the field of autoimmune disease treatments.

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What educational qualifications are required for the Postdoctoral Fellow role at AstraZeneca?

To be considered for the Postdoctoral Fellow position in Treg Cell Therapy at AstraZeneca, you need to have a PhD in immunology, cell biology, molecular biology, or a related field. Additionally, relevant hands-on experience with cell culture assays and various molecular and cellular biology techniques such as DNA cloning and flow cytometry is essential to succeed in this role.

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What skills are desirable for applicants applying for the Postdoctoral Fellow position at AstraZeneca?

Desirable skills for the Postdoctoral Fellow in Treg Cell Therapy role at AstraZeneca include a strong understanding of immunology and cell biology, proficiency in molecular cloning, and experience with qPCR and multi-panel flow cytometry. Knowledge of in vivo experiments with autoimmune disease animal models and excellent communication skills are also highly valued, as they will facilitate collaboration and knowledge sharing within the team.

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What opportunities for professional growth does the Postdoctoral Fellow position offer at AstraZeneca?

The Postdoctoral Fellow position at AstraZeneca presents significant opportunities for professional growth, including the ability to lead your projects, foster innovative research, and collaborate with top experts in the field. You will also have support from the organization to publish your work and present at international conferences, helping you to build a strong professional reputation and expand your network in the scientific community.

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How does AstraZeneca promote a culture of inclusion and equity for Postdoctoral Fellows?

AstraZeneca is deeply committed to promoting a culture of inclusion and equity, ensuring that all candidates, including Postdoctoral Fellows, feel a sense of belonging. The recruitment process is designed to be equitable, welcoming applications from diverse candidates regardless of characteristics. The company is also dedicated to providing reasonable accommodations to support candidates' needs, helping them to perform at their best throughout their career journey.

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Common Interview Questions for Postdoctoral Fellow – Treg Cell Therapy
Can you explain your experience with Treg cell therapies?

When answering this question, highlight specific projects you’ve worked on related to Treg cell therapies, discussing methodologies you've employed and results you've achieved. Be sure to relate your experience to how it has prepared you for the Postdoctoral Fellow role at AstraZeneca, demonstrating your understanding of Treg biology and its clinical applications.

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What experimental techniques are you proficient in that are relevant to this role?

Respond by detailing your proficiency in relevant techniques such as DNA cloning, flow cytometry, and ELISA. Give specific examples of how you’ve applied these techniques in previous research and how they will be beneficial in the context of developing Treg cell therapies at AstraZeneca.

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How do you stay updated on advancements in immunology and cell therapy?

Discuss various methods you employ to stay informed, such as reading scientific journals, attending conferences, and participating in webinars. Mention any specific resources or communities you engage with and how these have enhanced your knowledge base related to immunology and cell therapies.

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Describe a challenging project you worked on and how you overcame difficulties.

Provide an example of a specific challenging project within the scope of cell biology or immunology. Detail the obstacles encountered, your thought process in overcoming them, and what you learned from the experience, relating it to the role at AstraZeneca.

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How do you approach collaboration with a multidisciplinary team?

Explain your collaborative style, mentioning prior experiences working with diverse groups. Highlight your communication skills and ability to integrate feedback from experts in different areas, which will be key for the collaborative environment at AstraZeneca.

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What are your thoughts on the current state of Treg research?

Share your insights on recent advancements and ongoing challenges in Treg research. Familiarize yourself with current literature and therapies being developed, and explain how your views align with AstraZeneca’s goals in advancing Treg cell therapies.

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How do you handle feedback from peers and supervisors?

Discuss the importance of constructive feedback in scientific research. Provide examples demonstrating how you've positively incorporated feedback in the past, improving your work and contributing to better team outcomes.

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What are your future research goals and how do they align with AstraZeneca's mission?

Articulate your long-term research goals and how they fit with AstraZeneca’s focus on innovative therapies for autoimmune diseases. Show your ambition and motivation for contributing to the field and aligning with the company’s mission to create life-changing medicines.

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How would you communicate complex scientific ideas to non-scientists?

Share your strategies for simplifying complex concepts and using analogies or visuals. Highlight any experiences you have had communicating research to varied audiences, emphasizing your skills in making science accessible, which is particularly important in collaborative environments.

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What excites you most about the possibility of joining AstraZeneca?

Express your enthusiasm for being part of a renowned company recognized for its innovative research in cell therapies. Discuss elements such as AstraZeneca’s commitment to science and its impact on health and how these align with your passion for making a meaningful contribution to humanity through your research.

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AstraZeneca is one of the world’s most exciting bio-pharmaceutical companies. From scientists to sales, lab techs to legal we’re on a mission to turn ideas into life-changing medicines that improve patients’ lives and benefit society. We’re consta...

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DATE POSTED
April 17, 2025

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