Biostatistician

COMPANY DESCRIPTION:

Alto Neuroscience is a clinical-stage biopharmaceutical company that integrates the biology of the patient into drug development to improve the lives of people with mental health conditions. Currently, there is no objective way to diagnose psychiatric illness, nor to identify which treatment is best for an individual patient. Treatment selection is presently done by trial-and-error as there are no tests that can inform these decisions. Through our AI-enabled biomarker platform, we combine rich sources of information on patients' brain activity and behavior to rapidly develop highly-effective medicines for targeted populations. We aim to replace today's trial-and-error clinical approach by aligning the right Alto drug with the right patient, redefining psychiatry at a time when the world needs it most. Come join us on our mission to re-imagine and re-engineer the treatment of mental illnesses!

PRIMARY ROLE:

This position will work with an inter-disciplinary team of physicians, research and data scientists and software developers to disrupt the current approaches to treating mental health conditions leveraging innovative machine learning and artificial intelligence techniques. The person in this position will help craft statistical analysis plans for clinical trials and oversee and perform statistical analyses of crossover, open label, and randomized trials.

DUTIES AND RESPONSIBILITIES:

• Work with investigators to formalize analysis plans, advise on statistical analysis strategies, and interpretation and presentation of statistical results
• Write Statistical Analysis Plans and conduct power analyses for future trials
• Assist in the preparation of clinical trial documents and reports, protocols, brochures, peer-reviewed manuscripts, and responses to requests from regulatory agencies
• Use advanced statistical software, methods, and techniques to analyze and interpret clinical data; advise and assist in the development of conclusions (as appropriate)
• Stay apprised of best practices in clinical trials analysis, as well as best practices for sensitivity analyses
• Collaborate with other data scientists as well as clinical experts to ideate and solve complex issues pertinent to data ingestion/curation, modality integration, model performance, model generalization.
• Document code, results, and details of the approaches in a thorough and systematic way in order to promote knowledge sharing and code re-use.
• Research and recommend new and innovative approaches to analyzing complex data sets to advance mental health research objectives.
• Present research findings to internal leadership and stakeholders.
• Other duties and projects as determined by the CDSO

• QUALIFICATIONS:

• Master or PhD degree in Biostatistics, Statistics, or other quantitative fields with strong applied analysis experience
• 3+ years of clinical trials experience
• Excellent understanding of longitudinal modeling
• Experience with causal inference
• Experience with sensitivity analyses for missing data
• Experience in developing and writing Statistical Analysis Plans
• Expertise with common statistical software programs such as SAS, Stata, and R
• A team player focused first on the company mission
• Strong organizational, problem-solving, and analytical skills, communication, and interpersonal skills; able to manage priorities and workflow.
• Versatility, flexibility, and a willingness to work within constantly changing priorities with enthusiasm
• Self-motivated and curious with a strong desire for continuous learning
• Strong business acumen

COMPETENCIES:

• Ethics and Dependability: Develops effective working relationships with peers, manager, direct reports, senior management, and board of directors. Follows instructions to achieve established goals, takes responsibility for own actions all while treating people with respect, consideration and upholding organizational values.
• Results: Place a top priority on achieving desired results by conveying a sense of urgency, overcoming barriers, maintaining a high level of productivity, and monitoring progress while staying within time and budget requirements. The ability to focus on the desired result of one's own or team members work, setting challenging goals, focusing effort on the goals, and meeting or exceeding them.
• Accountability: Identifying what needs to be done and doing it before being asked or before the situation requires it. Takes personal ownership in the company's success and accepts full responsibility for oneself and contribution as a team member. Consistently delivers on commitments and meets commitments to others.
• Collaboration: The ability to develop, maintain, and strengthen partnerships with others inside or outside the organization who can provide information, assistance, and support. Supports and helps other employees in their work in order to contribute to the overall success of the company.
• Adaptability: Demonstrates comprehension of skills, processes and procedures in order to effectively complete assigned responsibilities. Develops alternate solutions to challenges and utilizes resources to aid in problem-solving. Exhibits solutions-oriented attitude, with ability to deal with frequent change, delays or unexpected events as they arise.
• Leadership: Gains the confidence and trust of others by fulfilling commitments, accepting responsibility, and expressing views openly. Provides direction and support which is in alignment with corporate goals. Ensures appropriate cross-functional collaboration.

PHYSICAL DEMANDS AND WORK ENVIORNMENT:

• Required to sit for prolonged periods of time
• While performing the duties of this job, the noise level in the work environment is usually quiet
• The employee must occasionally lift and /or move more than 50 pounds

The above is intended to describe the general content of and requirements for the performance of this job. It is not to be construed as an exhaustive statement of duties, responsibilities or physical requirements. Nothing in this job description restricts management's right to assign or reassign duties and responsibilities to this job at any time. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

PI208085628