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Principal Scientist/Associate Director Immunology

Hillstar Bio, is a precision immunology company that recently completed a sizable Series A financing with a syndicate of blue-chip investors. Our passionate team of drug developers is based in Boston’s Seaport neighborhood.

Hillstar is advancing a portfolio of programs against autoimmune diseases with unmet or underserved medical needs. Its lead program is an antibody designed to selectively target a root cause of Cold Agglutinin Disease (CAD) and other autoimmune diseases. CAD is a chronic, rare (incidence 15/million) but debilitating condition with high morbidity (anemia, fatigue, cold-induced circulatory symptoms). Existing treatment options for CAD have limited effectiveness, carry considerable safety risks, and fail to address key disease symptoms in a large proportion of patients, leading to significant chronic morbidity and excess mortality. By bringing this new precision modality to patients, Hillstar aims to improve on safety and efficacy, as well as durability of response, setting a new gold standard for the management of CAD, and other serious autoimmune conditions with a common biological origin.

 

Job Description

Join Hillstar Bio as a Principal Scientist/Associate Director of Immunology, acting as the immunology project leader for our second program, HLST-002. This will include designing, managing, and overseeing the execution of the in vitro and in vivo mechanistic, efficacy, and safety studies for HLST-002. This role requires scientific and technical expertise in adaptive immune cell biology and strategic thinking in how we expand our team to advance HLST-002.

This pivotal role offers someone the opportunity to lead the immunology design of an exciting program targeting a significant unmet need for patients. We seek a passionate, collaborative scientist, who is a team player and ready to thrive in a dynamic, close-knit team environment.

Essential Duties and Responsibilities

  • Design and oversee execution and analysis of in vitro and in vivo experiments to investigate disease-causing mechanisms and generate proof-of-concept studies
  • Research and identify high quality in vitro and in vivo models of autoimmune diseases; working with the VP of Immunology create the overall preclinical strategy for HLST-002 and support the design of subsequent PK, tox, dosing studies
  • Work with Scientists and RAs on detailed experimental plans and processes, including identification of appropriate controls, assay optimization, reagent selection, etc. for standard immunology and cell bio techniques (ELISA, flow cytometry, immunofluorescence, cell sorting, Western blotting, etc.)
  • Identify high quality external CRO, vendor, and academic collaborators, and determine how they fit into a broader scientific workplan for HLST-002; work with external collaborators on detailed experimental design and interpretation of results
  • Present finding and project updates to internal research and executive teams
  • Assist in authoring technical reports for IP and regulatory filings
  • Play a key role in building and fostering Hillstar’s culture and contribute to the growth and leadership of the immunology team
  • Collaborate on various aspects of general business, lab operations, and people operations as needed

Qualifications

    • PhD in Immunology or related field.
    • A minimum of 5 years of experience in drug development in biotech or pharma setting, with research experience in autoimmune diseases
    • Prior experience with adaptive (B and/or T cell)-mediated autoimmune diseases, experience seeing these programs through non-clinical into early clinical studies is highly preferred
    • Prior experience advancing a program from early stage of conceptualization through in vitro and in vivo preclinical studies in a biotech or pharma context
    • Prior experience managing junior lab-based scientists (e.g., RA, Scientist, Sr Scientist) and CRO/academic collaborations
    • Relevant experience is reflected by a track record of patents and high impact publications.
    • Demonstrated excellence as a team player as evidenced by positive reviews from reports, peers, and managers
    • Self-motivated, collaborative, excellent time management and interpersonal skills.
    • Demonstrated ability to communicate scientific workplans, strategy, and findings through presentations and slides.
    • Experience with antibody development is a plus

Hillstar Bio offers a competitive compensation and benefits package that includes unlimited vacation and market-leading parental leave.

Additional Information

This is a full-time position located in our Boston, MA office. Hillstar is committed to creating a diverse work culture and we are seeking individuals of all backgrounds, orientations, and identities. We are an equal opportunity employer and do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Average salary estimate

$150000 / YEARLY (est.)
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$120000K
$180000K

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What You Should Know About Principal Scientist/Associate Director Immunology, Hillstar Bio

At Hillstar Bio, we're on the cutting edge of precision immunology, and we’re looking for a passionate Principal Scientist/Associate Director of Immunology to join our dynamic team in Boston’s vibrant Seaport neighborhood. You will play a pivotal role in leading our exciting program, HLST-002, by designing and overseeing in vitro and in vivo mechanistic, efficacy, and safety studies. Your expertise in adaptive immune cell biology will be crucial for advancing our mission to address autoimmune diseases with unmet medical needs. This is not just a job; it's an opportunity to make a real difference in the lives of patients suffering from conditions such as Cold Agglutinin Disease (CAD). In this role, you’ll collaborate closely with other talented scientists, manage junior lab-based staff, and work with external CROs to develop a comprehensive preclinical strategy. We are counting on your expertise to investigate disease mechanisms and generate proof-of-concept studies, while also contributing to Hillstar’s collaborative culture. Your skills in assay optimization and presentation of project updates will help us set a new standard in managing autoimmune diseases. If you are self-motivated, possess excellent time management skills, and thrive in a close-knit team environment, we'd love to have you on board. Join us at Hillstar Bio to redefine the future of autoimmune disease treatments!

Frequently Asked Questions (FAQs) for Principal Scientist/Associate Director Immunology Role at Hillstar Bio
What are the responsibilities of a Principal Scientist/Associate Director of Immunology at Hillstar Bio?

As a Principal Scientist/Associate Director of Immunology at Hillstar Bio, you will be responsible for designing and executing in vitro and in vivo studies, overseeing the development of experimental plans, collaborating with teams to analyze results, and managing relationships with external collaborators. Your strategic vision and scientific expertise will guide the advancement of our program HLST-002, targeting significant unmet needs in autoimmune diseases.

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What qualifications do I need for the Principal Scientist/Associate Director of Immunology position at Hillstar Bio?

To qualify for the Principal Scientist/Associate Director of Immunology role at Hillstar Bio, you should hold a PhD in Immunology or a related field, alongside at least 5 years of experience in drug development specifically focused on autoimmune diseases. A strong background in adaptive immune cell biology, patent applications, and high-impact publications will also enhance your candidacy.

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What skills are essential for a Principal Scientist/Associate Director of Immunology at Hillstar Bio?

The essential skills for this role at Hillstar Bio include a deep knowledge of immune cell biology, excellent strategic thinking abilities, and proficient communication skills. Self-motivation, collaboration, and effective time management are crucial, along with a demonstrated ability to manage junior scientists and coordinate with external collaborators effectively.

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How does Hillstar Bio support its scientists in professional growth?

Hillstar Bio supports its scientists, including the Principal Scientist/Associate Director of Immunology, through a culture that fosters collaboration and growth. We offer competitive compensation packages, including unlimited vacation and market-leading parental leave, ensuring our team members can thrive both professionally and personally.

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What impact does HLST-002 aim to make in the field of autoimmune diseases?

HLST-002 at Hillstar Bio is designed to focus on significant unmet medical needs in autoimmune diseases, particularly Cold Agglutinin Disease. Our goal is to improve safety, efficacy, and durability of response to treatments, ultimately setting new standards for patient care and management of these debilitating conditions.

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Common Interview Questions for Principal Scientist/Associate Director Immunology
Can you describe your experience with adaptive immune cell biology?

Certainly! In my previous roles, I worked extensively with B and T cell-mediated responses, focusing on how they contribute to autoimmune conditions. During interviews, emphasize specific research projects or experiences that demonstrate your theoretical knowledge and practical skills—that’s what most interviewers will want to hear.

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How do you approach designing preclinical studies for autoimmune diseases?

My approach includes thorough background research to identify viable in vitro and in vivo models relevant to the disease in question. I also stress collaboration with cross-functional teams to ensure that all experimental designs are robust, reproducible, and easily interpretable. Providing examples from your past experience can greatly strengthen your response.

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What strategies do you use to manage and mentor junior scientists?

I believe in open communication and setting clear expectations. By fostering a collaborative environment, I encourage junior scientists to voice their ideas and challenges. In interviews, cite instances where your mentoring made a significant difference in someone’s career path, showcasing your leadership.

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What are the most critical factors to consider when collaborating with external CROs?

Key factors include ensuring alignment on scientific objectives, clear communication, and establishing a comprehensive project timeline. Discuss how you’ve navigated collaborations in the past by providing examples of successful partnerships that led to meaningful results.

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How do you ensure your results are reproducible and reliable?

To ensure reproducibility, I follow standardized protocols, carefully choose appropriate controls, and document every step taken during experiments. In interviews, you can discuss any quality control measures or audits you’ve implemented in previous projects as proof of your diligence.

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Can you describe a time you successfully presented complex scientific data?

Absolutely! A memorable instance was when I presented findings from a crucial project to executive teams. I focused on breaking the data into digestible parts and used visuals for clarity. Discussing your preparation process and feedback received will demonstrate your effectiveness in this area.

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What motivates you in the field of immunology?

My passion lies in advancing our understanding of autoimmune diseases and the potential to improve patient outcomes through targeted therapies. In interviews, narrate a poignant story that touches upon what specifically drives your enthusiasm for this field.

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What challenges have you faced in drug development, and how did you overcome them?

One of the biggest challenges was navigating unexpected results during preclinical trials. I addressed this by gathering my team for brainstorming sessions which led to innovative troubleshooting solutions. Sharing specific examples will reflect your problem-solving skills effectively.

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How do you prioritize your workload during complex projects?

I prioritize by assessing project timelines, potential impact, and dependencies of tasks. Using project management tools has also been helpful. In an interview, it’s effective to provide an example of a project that had competing priorities and how you successfully managed them.

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What do you see as the future of immunotherapy for autoimmune diseases?

The future will likely involve more personalized approaches, targeting the root causes of diseases rather than merely alleviating symptoms. This is an exciting area to explore in interviews, as it allows you to express your knowledge of current trends and potential developments in the field.

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DATE POSTED
December 21, 2024

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