In Vitro ADME Scientist

6000! That’s the number of associates in the Novartis Institutes for BioMedical Research (NIBR).

NIBR is the innovation engine of Novartis, with a focus on discovering innovative new drugs that will change the practice of medicine. We have an open and entrepreneurial culture, encouraging collaboration internally and externally with academic groups and within industry alliances to make effective therapies. Growing the area of new modality therapeutics is part of the longer-term strategic plan and investment of Novartis, and this role will facilitate the absorption, distribution, metabolism, and excretion (ADME) optimization of new modality therapeutics in close collaboration with other line functions and disease areas at NIBR.

New drug modalities including oligonucleotides, antibody-drug conjugates or AAV gene therapies have the potential to target previously undruggable diseases. Come join the In Vitro ADME group in Pharmacokinetic Sciences (PKS) at Novartis Institutes for BioMedical Research (NIBR) to help unlock these innovative medicines and bring improved treatments to patients in need.

The In Vitro ADME group within PKS is looking for a highly motivated multi-disciplinary team-oriented scientist with a cell biology background and experience on characterizing in vitro cellular disposition of non-traditional therapeutics. The selected candidate will provide support for a diverse portfolio that includes oligonucleotides, antibody-drug conjugates, targeted bi-functional degraders, and other molecules in the beyond rule-of-5 property space.

Responsibilities:

• Troubleshooting, development, and validation of new ADME cell-based assays and technologies to support pre-clinical project teams.
• Design and conduct cell culture experiments to profile compounds beyond rule-of-5 property.
• Investigate protein and cellular binding, cellular uptake, trafficking, endosomal escape, and the metabolic fate of small and large molecules.
• Present results at departmental forums as well as to project teams and contribute to publication in scientific journals.
• Provide training and mentorship to team members.

Requirements:

• M.S. in Cell and Molecular Biology, Pharmaceutical Sciences, Biochemistry or a closely related discipline with 0-4 years work experience is desired; Ph.D. is preferred.
• Understanding of bioanalysis utilizing LC-MS with special emphasis on large molecules (e. g. oligonucleotides) and the application to in vitro ADME sample analysis in a drug discovery setting is desirable.
• Experience with high content imaging platforms and laboratory automation systems is preferable.
• Experience with cell culture (2D and 3D) and molecular biology techniques such as immunofluorescence, qPCR, ELISA or FACS and their application to the intracellular fate of molecules in the beyond rule-of-5 property space is highly desirable.
• A good understanding of laboratory equipment and associated software is desirable.
• Strong experimental and problem-solving skills, excellent collaboration and communication skills (both written and oral), and an eagerness to learn.
• Time management skills and ability to work in a team-based drug discovery/development environment.

Why Novartis
766 million lives were touched by Novartis medicines in 2021, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives.

We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.

We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying!
Imagine what you could do here at Novartis!

Commitment to Diversity & Inclusion:
Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.

Accessibility and Reasonable Accommodations: The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please send an e-mail to tas.nacomms@novartis.com call +1 (877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

The pay range for this position at commencement of employment is expected to be between $88,000 and $132,000/ year; however, fluctuations in the job market may necessitate adjustments to pay ranges during this period. Further, final pay determinations will depend on various factors, including, but not limited to geographical location, experience level, knowledge, skills and abilities. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance

Novartis Institutes for BioMedical Research

Translational Medicine

USA

Cambridge, MA

NIBRI

Research & Development

Full Time

Regular

No

No