Research Associate, Flow Analytical Development

Kyverna Therapeutics is a patient-centered, clinical-stage biopharmaceutical company focused on developing cell therapies for patients suffering from autoimmune diseases. The Kyverna therapeutic platform leverages advanced T cell engineering to suppress and eliminate autoreactive immune cells at the origin of autoimmune and inflammatory diseases. Be at the forefront of cell therapy innovation by joining scientists, industry veterans and healthcare visionaries and help transform how autoimmune diseases are treated

Kyverna is recruiting a highly motivated Research Associate, Flow Analytical Development to contribute to flow cytometry assay development in its Analytical Development group to help advance its mission to free patients from the siege of autoimmune disease.  The candidate will be responsible for performing laboratory-based studies and providing technical expertise to design, develop, optimize, validate, qualify and tech transfer methods across technologies including cell-based assays(T cell culture, potency assay, proliferation, etc),immunoassays (multiplex immunoassays, single cell-based proteomics), and multi-color flow cytometry.  

The ideal candidate will develop methods to characterize, monitor, and understand the attributes of engineered cells that are part of the Kyverna pipeline using advanced technologies and lead assay qualification/validation to support pipeline programs. The ideal candidate will contribute to our goals of navigating what’s next in gene transfer technologies, immunology and cell engineering while living our core values: Bring Intellectual Rigor, Elevate Each Other, and Stay True To Why.  

• Support development of robust flow cytometry assays and panels to characterize and phenotype starting material, in-process and engineered cellular products.  
• Assist with methods qualification and validation in support of regulatory filing and tech transfer. 
• Support in-house Process Development by providing analytical testing and data analysis.  
• Analyze data to support regulatory filings and evaluate new technologies. 
• Support operation and management of Technical Development workflows  
• Work with typical biological software such as Benchling, FlowJo, Prism. 
• Organize data for writing test procedures, SOPs, and protocols. 
• Maintain good electronic notebook record of performed studies. 
• Collaborate with research and technical development within Kyverna and CMO/CRO organizations supporting the business.  
• Other duties as assigned.

• Bachelor’s or Master’s degree with 1+ years of industry experience in biological sciences such as biochemistry, molecular and cell biology, or a related discipline. T cell biology and immunology background are preferred.  
• Experience with multi-color flow cytometry. Experience with complex cell phenotyping panels preferred. Previous experience using Beckman Coulter Cytoflex flow cytometers a plus but not required.  
• 1+ years of experience with mammalian tissue culture including both adherent and suspension cells. 
• Previous experience with Benchling and flow cytometry analysis programs such as Flowjo or Cellengine strongly preferred. 
• Experience with immunostaining and visualization assays such as immunofluorescence staining and microscopy a plus.  
• Experience with immunoassays such as ELISA, Ella, Isoplex, MSD, and Western blot analysis a plus. 
• Ability to execute experiments with minimal technical supervision. 
• Ability to multitask, work effectively as part of a team and meet deadlines in a fast-paced environment.
• Ability to think critically and demonstrate troubleshooting and problem-solving skills. 
• Document laboratory procedures and experiments with great attention to detail and maintain accurate lab records and notebooks. 
• Author protocols, reports and standard operating procedure documents as needed. 

The salary range for this position is from $75,000 - $90,000 USD annually. This salary range is an estimate of what we reasonably expect to pay for this posted position, and the actual salary may vary based on various factors, including without limitation individual education, experience, tenure, skills and abilities, as well as internal equity and alignment with market data.  This position is also eligible for bonus, benefits, and participation in Company’s stock option plan.

Kyverna is an Equal Opportunity Employer and prohibits discrimination and harassment of any kind. Kyverna is committed to the principle of equal employment opportunity for all employees and does not discriminate on the basis of race, religion, color, sex, gender identify, sexual orientation, age, non-disqualifying physical or mental disability, national origin, veteran status or any other legally protected status. EOE/AA/Vets