Research Associate II - Transgenic Knockout Program

About City of Hope

City of Hope's mission is to deliver the cures of tomorrow to the people who need them today. Founded in 1913, City of Hope has grown into one of the largest cancer research and treatment organizations in the U.S. and one of the leading research centers for diabetes and other life-threatening illnesses. City of Hope research has been the basis for numerous breakthrough cancer medicines, as well as human synthetic insulin and monoclonal antibodies. With an independent, National Cancer Institute-designated comprehensive cancer center at its core, City of Hope brings a uniquely integrated model to patients spanning cancer care, research and development, academics and training, and innovation initiatives. City of Hope’s growing national system includes its Los Angeles campus, a network of clinical care locations across Southern California, a new cancer center in Orange County, California, and treatment facilities in Atlanta, Chicago and Phoenix. City of Hope’s affiliated group of organizations includes Translational Genomics Research Institute and AccessHopeTM. For more information about City of Hope, follow us on Facebook, Twitter, YouTube, Instagram and LinkedIn.

City of Hope’s commitment to Diversity, Equity and Inclusion

We believe diversity, equity and inclusion is key in serving our mission to provide compassionate patient care, drive innovative discovery, and advance vital education focused on eliminating cancer and diabetes in all of our communities. Our commitment to Diversity, Equity and Inclusion ensures we bring the full range of skills, perspectives, cultural backgrounds and experiences to our work - and that our teams align with the people we serve in order to build trust and understanding. We are dedicated to fostering a community that embraces diversity - in ideas, backgrounds and perspectives; this is reflected in our work and represented in our people.

Position Summary

Under general supervision of the Principal Investigator, or designee, the Research Associate II (RAII) will undertake research projects and make innovative contributions pertaining to laboratory procedures. These efforts may not change the course of an investigation but do indicate significant independent contribution beyond the RA I level. RAII typically consults with the academic supervisor on the scope and plan of approach to a research project; reads abstracts and articles; organize and plan techniques; contribute original ideas to the laboratory research; standardize new techniques and train staff on these techniques; perform specialized procedures and prepare written reports of laboratory experimental methods.

Key Responsibilities include:

The Transgenic mouse core facility produces genetically modified mice as a service to researchers at the City of Hope, and, as such, the desired candidates must possess a high level of dedication and professionalism. The RA will be able to perform a variety of tasks necessary to the function of the TKP (Transgenic Knockout Program) that include, but are not limited to, the following:

• Handling laboratory mice; in vitro culture of mouse embryos; micro-manipulation of mouse embryos; surgical and non-surgical embryo transfer in mice, in vitro culture of mouse embryonic stem cells (mESC); cryopreservation/rederivation of mouse strains; management of mouse breeding colonies.
• The RA will also perform molecular biology and microscopy techniques used to generate and genotype genetically modified mice.
• Performs a variety of routine and non-routine laboratory research experiments. Records and validates results for accuracy and completeness.
• Troubleshoots procedures if experiment results are unexpected or unsatisfactory. Recommends alternative procedures.
• Responsible for accurately recording work peformed including results and methodology. Calculates, compiles, and analyzes data obtained from work performed.
• Independently evaluates research data and initiates alternative approaches to improve the quality of results by providing input to overall research design. Trains lab staff in specialized procedures, equipment, and theoretical concepts behind unique tests.
• May contribute to the preparation of manuscripts by describing methods and specialized techniques. Keeps abreast of new and improved techniques.
• Ensures that all laboratory activities are carried out in compliance with each procedure(s) by utilizing safety procedures and guidelines in handling, storage, and disposal of bio-hazardous, infectious and toxic material.
• The RA position requires availability on weekends as needed.
• This position may start at the level of Research Associate I dependent upon skills and experience of the candidate.

Basic education, experience and skills required for consideration:

• Bachelor’s degree.
• Two years related research/ laboratory experience with a Bachelor’s degree

or one-year related research/ laboratory experience with a Master’s degree.

Preferred education, experience and skills:

• Master’s degree preferred.

Additional Information:

• The estimated pay scale represents the typical [salary/hourly] range City of Hope reasonably expects to pay for this position, with offers determined based on several factors which may include, but not be limited to, the candidate’s experience, expertise, skills, education, job scope, training, internal equity, geography/market, etc. This pay scale is subject to change from time to time.
• As a condition of employment, City of Hope requires staff to comply with all state and federal vaccination mandates.

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.