Senior Scientist - In vitro, Bioscience Cardiovascular

Do you have a passion for Science? Would you like to apply your expertise to impact a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!
At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.

About AstraZeneca in Gaithersburg, MD:
Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration.

The Gaithersburg site offers a variety of amenities to help boost productivity and help keep our employees stay happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you’ll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams.

About Our Group:
In the Bioscience Cardiovascular department within Early CVRM, we focus on identifying and validating new drug targets for patients with cardiovascular disease and heart failure as well as evaluating pharmacological aspects, e.g. efficacy and mechanism of action, of new compounds crafted to hit these targets. The team delivers key data to projects across all phases of the drug discovery and development, and we work with different modalities such as stem cells, AAV, antibodies, small molecules, modified mRNA, antisense oligonucleotides and peptides.

Main Duties & Responsibilities

• We are seeking a skilled and highly motivated Senior Scientist to enhance our in vitro capabilities in cardiovascular disease.

• Conducts routine cell culture experiments independently by applying molecular and cellular biology techniques.

• Conducts hands-on primary cell culturing, and cell functional assays.

• Able to manipulate and characterize primary cells and cell lines.

• Contributes to the experiment plans and designs, communicates the results to team members and is involved in the interpretation of data.

• Supports drug project teams and works collaboratively with project managers to ensure the efficient relay of information and forward translation of data.

• Assesses and reports data, with little or no guidance, in a clear and concise manner, with a clear understanding of its implications within the overall context of drug discovery.

• Communicates and shares information between distinct projects within the bioscience function and across other functions.

• Ensures own work, and work of peers, is compliant with Good Laboratory Practice, Safety, Health and Environment standards and all other relevant internal AstraZeneca standards and external regulations.

Required Skills

• Senior Scientist: BS and 10+ years or MS and 8+ years of relevant experience, or a PhD or equivalent and/or professional certifications with 0-3 years of post-doctoral training, preferentially in cardiovascular disease area

• Proficient in culturing and manipulating human primary cells and cell lines

• Proficient in trouble shooting and theory.

• Well-developed understanding and expertise in molecular and cellular biology of cardiovascular relevant cells, design and performing functional and image-based assays, cell transfection/ transduction.

• Excellent team player with good interpersonal skills.

Desired Skills

• Good communication and networking skills

• In vitro and cell-based assay development skills

• Education and Experience

Why AstraZeneca?
At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening new ways to work, pioneering cutting edge science and bringing unexpected teams together. Interested? Come and join our journey.

So, what’s next?
Are you already imagining yourself joining our team? Good, because we can’t wait to hear from you!