Research Associate/Sr. Research Associate, Organic Chemistry

Circle Pharma is a dynamic biotech company advancing the discovery and development of cell-permeable oral macrocycles. Our platform combines structure-based drug design and advanced synthetic chemistry to create first-in-class macrocycle therapeutics for severe unmet clinical needs. We are focusing our development efforts on cyclins, which are master regulators of the machinery that controls progression of cells through the cell cycle and are key drivers in many cancers.

We seek passionate individuals poised to drive our growth and make a difference. Learn more about Circle Pharma at www.circlepharma.com

We are seeking a talented and motivated Research Associate/Sr. Research Associate in Organic Chemistry to join our expanding team. In this role, you will report to and work closely with a Scientist from our Chemistry department, contributing to the synthesis, purification and tracking of target molecules. The ideal candidate will have a strong foundation in synthetic organic chemistry and a passion for advancing drug discovery initiatives.

This position is fully onsite at Circle’s South San Francisco location, Monday through Friday.

• Synthesize, purify, and characterize synthetic intermediates and final compounds on milligram-to-multigram scale using a wide range of synthetic methodologies
• Analyze results, generate reports, and communicate findings to the Chemistry Team regularly
• Collaborate with the Chemistry Team to develop new synthetic approaches and methodologies
• Maintain accurate and up to date electronic notebook documentation of laboratory activities
• Independently operate and oversee maintenance of selected lab equipment
• Be an active contributor to the efforts of our Chemistry Team, including opportunities to contribute to compound designs

• Bachelor’s or Master’s degree in Chemistry, Biochemistry, or related discipline
• 2-5+ years hands-on experience synthesizing organic compounds, preferably in an industry setting (more years of experience would qualify you for a Senior Research Associate position)
• Knowledgeable in organic synthesis techniques and conversant with current literature
• Must have experience with common laboratory equipment (LC-MS, Flash Chromatography systems, HPLC, etc.)
• High level of creativity, knowledge of reaction mechanisms, able to adapt synthetic problem-solving approaches to a variety of target compounds
• Self-motivated and independent with the ability to work under minimum supervision
• Organized and detail-oriented
• Must be able to manage competing priorities
• Adept at following written protocols and verbal instructions
• Strong written and verbal communication skills
• Demonstrates excellent note-taking skills
• Proficient in the use of Microsoft Office, ChemDraw, and MestReNova (or equivalent)
• Strong interest and experience working in a team setting
• Must be able and willing to work at lab bench/fume hood for the majority of the workday
• Must be able to lift/reach/manipulate laboratory equipment independently
• Ability to work fully onsite at Circle’s South San Francisco location, Monday – Friday

Circle Pharma recognizes that the success of our endeavors depends on the success of every team member. Your well-being is our top priority, and we are proud to offer a comprehensive total rewards package. Our benefits include but are not limited to medical, dental, and vision care. We also provide a 401(k) plan with a generous company contribution, and all of our offers contain a stock option component. We provide company-paid life insurance, short-term and long-term disability. Additionally, we provide many company-paid holidays, including a winter break at the close of the calendar year. 

Circle Pharma is an equal opportunity employer and committed to a diverse workplace. All applicants will be considered equally without regard to race, color, ethnicity, veteran status, religion, national origin, marital status, political affiliation, age, sex, sexual orientation, gender identity, disability status, membership in an organization or any other non-merit factors.