Scientist I/II, Organic Chemistry & Peptide Synthesis

Circle Pharma is a dynamic biotech company advancing the discovery and development of cell-permeable oral macrocycles. Our platform combines structure-based drug design and advanced synthetic chemistry to create first-in-class macrocycle therapeutics for severe unmet clinical needs. We are focusing our development efforts on cyclins, which are master regulators of the machinery that controls progression of cells through the cell cycle and are key drivers in many cancers.

We seek passionate individuals poised to drive our growth and make a difference. Learn more about Circle Pharma at www.circlepharma.com

We are looking to add a Scientist I/II to our growing Chemistry team. Our ideal candidate must have a strong background in synthetic organic chemistry with a focus in peptide chemistry and solid-phase peptide synthesis automation. Reporting to the Associate Director, Chemistry, this individual will contribute to drug discovery programs enabled by our computational/medicinal chemistry and biology teams. Specifically, this individual will design and synthesize macrocyclic peptides using a combination of solution and semi-automated peptide synthesis, contribute to medicinal chemistry discussions, and develop new synthetic methodologies to further develop our drug discovery platform.

This position requires the ability to work fully onsite at Circle’s South San Francisco location, Monday – Friday. To be considered for the role, applicants must provide a resume/CV as well as a research summary detailing their chemistry experience. Please be aware that submitting a research summary is required to move forward with your application.

• ·Design, synthesize, and characterize small molecules and peptide macrocycles
• ·Utilize a combination of solution-phase and automated solid-phase methodologies
• ·Work with medicinal chemists to identify and prioritize target molecule designs
• ·Collaborate with colleagues to plan efficient synthetic routes and workflows
• ·Collaborate with colleagues in chemistry and in research operations to plan efficient synthetic routes and purification workflows
• ·Identify and integrate cutting-edge chemistry to expand platform capabilities
• ·Maintain an in-depth knowledge of modern organic synthesis, medicinal chemistry, and project-related scientific literature
• ·Coordinate with CRO chemistry teams
• ·Maintain a safe work environment
• ·Actively contribute to and support the success of our Circle Team with enthusiasm and dedication

• PhD in Synthetic Organic Chemistry with at least 2 years of relevant post-doc or industry experience, or a BS/MS with 8+ years of industry experience and a strong track record of research accomplishments. Candidates with additional years of experience may be considered for a Scientist II position
• Experience and expertise in the use of modern synthetic organic techniques for small molecules. Experience in peptide synthesis, peptidomimetics, and natural product synthesis preferred
• Experience in medicinal chemistry and/or library synthesis
• Conversant with current literature
• Demonstrated ability to troubleshoot synthetic routes and difficult chemistries
• High level of creativity, knowledge of reaction mechanisms, and strong synthetic problem-solving skills, including identifying multiple synthetic approaches to a given compound
• Adept in structural determination using NMR and Mass Spectral techniques, as well as a strong background in analytical techniques in LC-MS and purification methods
• Possess a strong desire to learn new techniques and incorporate new methodologies
• Proficient in the use of Microsoft Office, ChemDraw, MestReNova and Mac/PC operating systems
• Excellent at maintaining laboratory records of scientific findings
• Excellent record of maintaining laboratory safety standards
• Self-motivated and independent with the ability to work under minimal supervision
• Ability to deliver high-quality outcomes within tight deadlines
• Solutions-oriented, self-driven, and able to think critically in a rapidly evolving environment. Passionate about contributing to Circle’s growth and mission
• Enjoyment in operating in an exceptionally dynamic, high-achieving and collaborative environment where every voice matters
• Demonstrated willingness to lead, champion, and operate with Circle’s Core Values

Circle Pharma recognizes that the success of our endeavors depends on the success of every team member. Your well-being is our top priority, and we are proud to offer a comprehensive total rewards package. Our benefits include but are not limited to medical, dental, and vision care. We also provide a 401(k) plan with a generous company contribution, and all of our offers contain a stock option component. We provide company-paid life insurance, short-term and long-term disability. Additionally, we provide many company-paid holidays, including a winter break at the close of the calendar year. 

Circle Pharma is an equal opportunity employer and committed to a diverse workplace. All applicants will be considered equally without regard to race, color, ethnicity, veteran status, religion, national origin, marital status, political affiliation, age, sex, sexual orientation, gender identity, disability status, membership in an organization or any other non-merit factors.