Job details

Scientist/Sr Scientist, Therapeutics

Earli exists to make cancer a benign experience. Earli does that by turning cancers against themselves: genetically forcing them to reveal themselves early, and then kill themselves – precisely and clearly distinguishable from benign lesions at early stages. Based on original technology from Stanford’s renowned Gambhir lab, Earli designs genetic constructs that are injected intravenously that turn cancer cells against themselves. These programmable synthetic promoter-reporter sequences “flip on” like light switches only in dysregulated cancer cells and turn them into "factories." The cancer is forced to produce either an epitope “docking station” for imaging agents, or a cytokine for immune system activation against the tumor. Thus, Earli’s platform enables immediate diagnosis and treatment of early cancers, rather than long-term observation that can lead to deadly metastatic recurrence.

Earli's synthetic target expression platform has evolved over five years of deep bioengineering. The system can now detect broad ranges of patient mutations, distinguish between malignant and benign lesions, and offer independence from often elusive natural biomarkers.

Who You Are

You share our same sense of dedication, scientific passion and entrepreneurial spirit
You work well in a fast-paced and extremely focused startup environment
You are not only smart, but clever and constantly think outside the box
You are able to make logical decisions in an instant when there is little time to evaluate
You are a natural communicator and relationship builder
You stay calm under high pressure and stress
You have the ability to multi-task in a serious way, with an extreme attention to detail
You become a representative of the core DNA of the company through who you are

The Position

Earli, Inc. is currently seeking a highly motivated and committed Scientist / Senior Scientist for our Therapeutics team with a background in immuno-oncology. This position will report to the Head of Therapeutics.

Your Primary Responsibilities

Earli’s platform technology uses cancer-activated gene expression to usurp the dysregulated pathways that lead to malignancy. As a scientist or senior scientist you will be leveraging this platform for the creation of novel immuno-oncology therapeutic approaches to treat cancer. Within this context, you will:

Utilize a wide variety of cellular immunology and molecular immunology techniques to contribute to the identification and validation of therapeutic targets
Design and execute strategies in preclinical in vitro and in vivo models for the development of novel gene therapy for the treatment of cancer.
Previous experience with cytokine, immuno-cytokine, immunomodulatory and/or bispecific T cell engagers therapeutics would be preferred
Use immunology techniques including cytokine analysis, functional assays, imaging, and cell biology in the context of the tumor microenvironment in order to ascertain mechanism of action or immune-based tumor-cell killing. Experience with cancer cell death-based immunogenicity and approaches to trigger that would be preferred.
Work with other team members to generate appropriate efficacy and safety data packages for the advancement of clinical candidates for regulatory submission.
Document results and communicate findings to internal teams and to external partners

Your Required Experience, Knowledge and Skill

PhD in immunology, cell biology, or a related discipline.
Minimum of 4+ years of industry experience developing immuno-oncology or gene therapy approaches that engage the immune system. Similar experience in graduate school or post doc would be an additional plus.
Have an exceptionally strong background in immuno-oncology or cellular mechanisms of oncogenesis including a proficient understanding of the innate and adaptive immune response to cancer.
Must have technical expertise with in vitro cellular & molecular immunology assays
Must be proficient with flow cytometry acquisition and analysis
Hands-on molecular biology experience that includes DNA and RNA isolation, various cloning techniques & strategies, PCR, qPCR, and standard biochemical assays
Previous experience with nucleic acid based expression approaches including viral and non-viral transductions methods as well as engineering cell lines for various readouts and functions is preferred
Must be able to think outside of the box
Ability to integrate and collaborate into a high achieving team environment
Ability to handle multiple projects simultaneously and meet aggressive project timelines
Exceptional verbal communication and scientific writing skills are required
Desire to continue to contribute in a laboratory focused role

The base salary for this position is $110-$145k per year

If interested in applying, please attach a CV or have a well-developed LinkedIn profile for us to be able to assess your background.

We look forward to hearing from you!

Average salary estimate

$127500 / YEARLY (est.)

min

max

$110000K

$145000K

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What You Should Know About Scientist/Sr Scientist, Therapeutics, Earli, Inc.

At Earli, we’re on a mission that’s as bold as it is essential: to make cancer a benign experience. We’re seeking a talented Scientist/Sr Scientist for our Therapeutics team in Redwood City, CA, to join us in this groundbreaking endeavor. If you're passionate about immuno-oncology and thrive in a fast-paced startup environment, you'll fit right in! In this role, you’ll leverage our cutting-edge platform technology, which uses ingenious cancer-activated gene expression to turn the tide against malignancy, helping to identify and validate innovative therapeutic targets. You’ll design and execute preclinical strategies using various in vitro and in vivo models that can change the way we fight cancer. Your expertise will enable us to develop effective immuno-oncology approaches, playing a pivotal role in transforming how early cancers are diagnosed and treated. Collaboration is key at Earli, and you'll partner with incredible minds to generate the safety and efficacy data required for regulatory submissions—this is where your technical know-how in immunology techniques, flow cytometry, molecular biology, and more will shine. We value dedication, clever problem-solving, and the ability to stay calm under pressure. If you're ready to make a tangible impact in the fight against cancer and help shape the future of healthcare, we can’t wait to meet you!

Frequently Asked Questions (FAQs) for Scientist/Sr Scientist, Therapeutics Role at Earli, Inc.

What are the primary responsibilities of the Scientist/Sr Scientist position at Earli?

As a Scientist/Sr Scientist at Earli, you’ll play a crucial role in leveraging our innovative platform technology for developing novel immuno-oncology therapeutic approaches. Your primary responsibilities will include utilizing cellular immunology and molecular immunology techniques to identify and validate therapeutic targets, executing preclinical strategies, and working closely with a team to generate safety and efficacy data for regulatory submissions.