Senior Scientist, Upstream Process Development

As a member of the CMC group, the Senior Scientist will contribute to Upstream Process Development (UPD) activities to advance Janux Therapeutic lead candidates from research to clinical development. This position will serve as SME to support oversight and collaboration with Contract Development and Manufacturing Organizations (CDMO) to progress development programs. The successful candidate will also be responsible for the design and hands-on execution of experiments to enhance process understanding of mammalian cell culture to support process improvements.

• Technical support and oversight of activities at CDMO partners to ensure cell line and cell culture activities meet project deliverables.
• Assist in the review of CDMO batch records and reports as well as writing regulatory filings.
• Identify areas for process improvement; design and perform upstream process development experiments, including process optimization and process characterization.
• Work collaboratively with downstream and analytical teams to execute plans for in-house development and production activities.
• Perform material generation using transient transfection or stable cell line to support research and development activities.
• Responsible for the day-to-day maintenance of the laboratory organization, equipment, and consumables to ensure highly efficient cell culture activities.
• Maintain detailed records of all experiments performed in accordance with SOPs and policies, ensuring compliance with all applicable regulations.
• Effectively analyze, organize, and communicate experimental results to colleagues and senior leadership.
• Other duties as deemed necessary.

• Ph.D. in Bioengineering, Chemical Engineering, or a related discipline + 3 – 6 years of postdoctoral experience or a BS/M.S. + 8 – 11 years of industry experience in biologics cell line or upstream process development.
• Strong background in mammalian upstream process development, including the use of statistical software e.g. JMP is highly desirable.
• Experience overseeing, coordinating and reviewing documents from CDMOs, such as batch records, release testing results, and process reports.
• Experience with protein purification is desirable.
• Flexibility, adaptability, and a willingness to expand skill set and responsibilities.
• Strong analytical skills and ability to work in a highly collaborative environment.
• Excellent written and oral communication skills.
• Availability on weekends or holidays may occasionally be necessary to meet project demands.

Job Type: Full-time

Benefits:

·         401K

·         Medical insurance

·         Dental insurance

·         Vision insurance

·         Supplemental disability insurance plans

·         Flexible schedule

·         Life insurance

·         Flexible vacation

·         Sick time

·         Incentive stock option plan

·         Relocation assistance

Schedule:

·         Monday to Friday

Work authorization:

·         United States (Required)

Additional Compensation:

·         Annual targeted bonus X%

Work Location:

·         On site (San Diego, CA)

EQUAL OPPORTUNITY EMPLOYER:

Janux Therapeutics, Inc. is an equal opportunity employer that is committed to providing a work environment free of harassment and discrimination based upon a protected category, as well as an environment free from retaliation for protected activity.

Notice to Recruiters and Third-Party Agencies

The Talent Acquisition team manages the recruitment and employment process for Janux. To protect the interests of all parties involved, Janux will only accept resumes from a recruiter once a fully-executed search agreement is in place. Agencies are hereby specifically directed not to contact Janux employees directly in an attempt to present candidates. Janux will consider any candidate for whom an Agency and/or Recruiter has submitted an unsolicited resume to have been referred, free of any charges or fees.