Principal Scientist

Job Description

At Gilead we believe every employee deserves a great leader. As a people leader now or in the future, we expect that you will model and create an environment of inclusion, be intentionally focused on the hiring, development, growth and retention of talent, and empower teams to align and achieve goals.

Job Description

As the largest, dedicated in-house cell therapy manufacturing network in the world, Kite has relentlessly focused on developing our industry-leading manufacturing capabilities to bring the hope of survival to more patients living with certain difficult-to-treat cancers.

We are seeking a self-motivated and enthusiastic person with a deep work ethic to join us as a Principal Scientist (at our Santa Monica, CA facility) within the Department of Translational Medicine (TM). In this position, you will work with the TM team to closely support clinical development of Kite’s chimeric antigen receptor (CAR-T) oncology programs. The successful person will aid in the design and implementation of translational plan pivotal to Kite’s CAR-T pipeline and aid in reverse translational initiatives (bedside to bench). A demonstrated ability to support clinical trial implementation, synthesize scientific data and communicate key findings cross-functionally is desired. You will also be asked to perform other duties as desired to support Kite’s pipeline development.

Key Responsibilities:

• Support design of CAR T clinical trial pharmacology and discovery biomarker plan
• Serve as TM lead and oversee delivery of key pharmacology data deliverables desired for registrational studies (pharmacodynamic, pharmacokinetic, safety related and detailed product characterization information)
• Work with Clinical Data Management and Biometrics to qualify data acquisition and aid in interpretation of analyses of clinical trial data
• Support the preparation of data packages for publication, presentation and/or submission to regulatory agencies
• Contribute to company-wide and external scientific discussions and engagement with key opinion leaders in the field
• Identify and establish agreements with contract research organizations (CRO) and support the transfer of novel methods
• Supply to internal technology evaluation, development, qualification, and implementation of imaginative assays for clinical biospecimen monitoring
• Write, review, and edit technical documents including SOPs, development/qualification of protocols and drafting of study reports
• Support globally regulatory requests including Investigational New Drug (IND), Biologics License Application (BLA) and other key global regulatory filing activities
• Other duties as applicable

Basic Qualifications:

• Doctorate and 8+ years of cell therapy, immunology, cancer biology experience OR
• Master’s and 10+ years of cell therapy, immunology, cancer biology experience OR
• Bachelor’s and 12+ years of cell therapy, immunology, cancer biology experience OR
• Associate and 14+ years of cell therapy, immunology, cancer biology experience OR
• High School Diploma/GED and 16+ years of cell therapy, immunology, cancer biology experience

Preferred Qualifications:

• Familiarity in the areas of cell therapy, immunology, immuno-oncology and cancer biology
• Understanding of basic CAR-T cell pharmacokinetic and pharmacodynamic studies
• Previous clinical trial experience in the setting of translational biology is desirable
• Experience with clinical biospecimen testing, assay development and qualification
• Knowledge of laboratory information management system (LIMS) and electronic lab notebook record keeping (ELN)
• Excellent social, verbal and written communication skills are essential in this reciprocal work environment.
• Comfortable in a changing environment and able to adapt to changing priorities.
• Self-motivated and enthusiastic person with a meaningful work ethic
• Experience with data visualization for non-technical audiences
• Ability to work with cross-functional teams to coordinate assigned work and accomplish goals related to multi-dimensional data integration.
• Experience with single cell RNA sequencing, whole transcriptome sequencing, whole exome and whole genome sequencing, both germline and somatic.
• Experience in accessing, querying, and manipulating multi-dimensional data sources, including multiple source systems from databases.
• Thorough critical thinking, analytical and problem-solving skills, and ability to think creatively.
• Ability to interpret and summarize results from multi-omics datasets.
• Proficiency in R and Shell scripting within a Linux environment.
• Participated in immunology research projects spanning cancer immunotherapy, human immunology and human genetics.
• Experience analysis of large-scale antibody profiling, multiplex protein profiling, and flow cytometry.
• Familiarity with large genomic databases such as TCGA and GTEX, etc.
• Demonstrated leadership in translational studies investigating determinants of disease outcome and responsiveness to immunotherapy.
• Excellent publication background substantiated by first or last authorship contribution.

Does this sound like you? If so, apply today!

The salary range for this position is: $195,245.00 - $252,670.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans*.

For additional benefits information, visit:

https://www.gilead.com/careers/compensation-benefits-and-wellbeing

• Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans.

For jobs in the United States:

As an equal opportunity employer, Gilead Sciences Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact careers@gilead.com for assistance.

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