Job details

Research Associate I - Hacohen Lab - Immunotherapies

Job Description

The Hacohen Lab at the Broad Institute and Mass General Cancer Center seeks a highly motivated and well-organized candidate for a full-time Research Associate I position. The candidate will play a key role in advancing the lab’s research goals to understand the mechanisms driving resistance to immunotherapies using single-cell genomics with functional in vivo CRISPR screens. The lab has been working closely with MGH clinicians to study the immune response in patients with cancer and infections using leading-edge genomics and proteomics methods. In addition, they may use animal and cell culture models to analyze mechanisms of innate and adaptive immunity. The candidate will be responsible for designing and conducting experiments with their supervisor.

Principal duties and responsibilities:

Isolate immune cells from patient and mouse tumors and contribute to their characterization using advanced methods of single-cell molecular profiling. The candidate would work with primary cells from these tumors.

Techniques used will include: flow cytometry, cell sorting, cell culture, single-cell RNA-seq, PCR, DNA sequence analysis, western blotting and CRISPR technologies.

Independently carries out non-routine, highly specialized experimental procedures in histology, immunofluorescence, flow cytometry, molecular biology, mouse cellular immunology
Independently modifies and/or develops techniques and methodologies necessary to meet research and/or experimental needs.
Organizes workflow as needed and coordinates the scheduling of experiments.

Ordering laboratory reagents and maintaining mouse colonies for tumor immunity studies.

Maintain databases for patient-derived clinical specimens.

Organizes and accurately maintains written records of experimental procedures and data collection.
Contribute to the preparation of manuscripts resulting from data generated in research projects.
Performs advanced data analysis using complex software programs and statistical techniques.

May teach moderately difficult to complex lab techniques to students and research personnel.

Participates in weekly lab and project-related meetings.

Requirements:

Bachelors/Masters Degree in life science field
Proven track record of critical scientific thinking, multi-tasking ability, and strong analytical and problem-solving skills.
Excellent interpersonal and collaborative skills, and the ability to work both independently and as part of a team with scientists from a wide range of research expertise.
Outstanding verbal and written communication abilities.
Ability to adapt to and effectively manage changes in a fast paced and dynamic environment.
High level of initiative and the ability to work with little supervision.

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

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