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Senior Director, Measurement Data Science #2570

GRAIL is a healthcare company whose mission is to detect cancer early, when it can be cured. GRAIL is focused on alleviating the global burden of cancer by developing pioneering technology to detect and identify multiple deadly cancer types early. The company is using the power of next-generation sequencing, population-scale clinical studies, and state-of-the-art computer science and data science to enhance the scientific understanding of cancer biology, and to develop its multi-cancer early detection blood test. GRAIL is headquartered in Menlo Park, CA with locations in Washington, D.C., North Carolina, and the United Kingdom. GRAIL, LLC is a wholly-owned subsidiary of Illumina, Inc. (NASDAQ:ILMN). For more information, please visit www.grail.com.

This role is part of a larger Bioinformatics & Data Science team at GRAIL whose work is at the heart of the company’s products: from diagnostic classifier algorithms for cancer screening to scientific software pipelines for rapid model development. Within this team, you will lead the data science function focused on all aspects of measurement data: design-of-experiments, measurement systems analysis, statistical process control, non-clinical assay bioinformatics, scientific data management, and study design. You will work with diverse teams including biostatistics, software, clinical, regulatory, operations, research, product development, and external collaborators. Your work will result in exciting discoveries in cancer biology, impactful publications, and potential future products. You will report to Amoolya Singh, Chief Scientific Officer and SVP data science.

Responsibilities

Lead and grow a group of bioinformaticians and computational biologists working to design, run, or analyze experiments to discover and measure cancer signals in a variety of research, clinical, and production assays
Members of your team may be matrixed to a variety of projects involving biomarker discovery and validation; assay design, development, or validation; non-clinical or clinical study designs; and translational research
Partner with peers leading ML/computational biology research and translational bioinformatics to iteratively develop novel biological insights and computational models for diagnostics and pharma applications
Collaborate closely with lab operations, data engineering, biostatistics, regulatory, and clinical surveillance teams on analytical & clinical validation for regulated diagnostics products
Represent the organization at strategic meetings with internal or external advisory boards and regulatory agencies

Requirements

PhD in bioinformatics, computational biology, statistics or biostatistics, mathematics, biophysics, or related field
12+ years post-PhD experience in the biotech or biopharma sector, which includes domain expertise in at least two of the following disciplines: genomics, metabolomics or proteomics, high-throughput screening, biomarker informatics, research study or clinical trial design, analysis of real-world evidence
Mastery in principles of industrial statistics, including any of the following: design-of-experiments (factorial, response surface, adaptive designs), measurement systems analysis (accuracy, precision, linearity, bias, repeatability, reproducibility), or statistical process control (partition of variance, control charting, outlier detection and monitoring, voice of the process)
Expertise in mathematical & statistical modeling, including supervised and unsupervised learning, feature & model selection, principles of model training/test/validation
Demonstrated experience in working collaboratively under tight deadlines and balancing the needs of multiple key stakeholders
Results-oriented: superb follow-through, drive, and creative problem-solving
Clear, positive, and proactive communicator in verbal and written communications
Outstanding manager with unconscious competence in relevant best practices (e.g. active listening, delegation, feedback, resolving conflict, coaching, and career development)

Bonus

Experience with diagnostics, data curation or data engineering, or clinical/non-clinical data management
Experience with regulatory filings in diagnostics or drug development (e.g. (IND, PMA, NDA)
Six Sigma expertise

The estimated, full-time, annual base pay scale for this position is $244,000 - $309,000. Actual base pay will consider skills, experience, and location.

Based on the role, colleagues may be eligible to participate in an annual bonus plan tied to company and individual performance, or an incentive plan. We also offer a long-term incentive plan to align company and colleague success over time.

In addition, GRAIL offers a progressive benefit package, including flexible time-off, a 401k with a company match, and alongside our medical, dental, vision plans, carefully selected mindfulness offerings.

GRAIL is an Equal Employment Office and Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status. We will reasonably accommodate all individuals with disabilities so that they can participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Following extensive monitoring, consideration of business implications, and advice from internal and external experts, GRAIL US has made the decision to require that all U.S. employees be “Fully Vaccinated” with the COVID-19 vaccine. “Fully Vaccinated” is defined as two weeks after both doses of a two-dose vaccine (e.g. Pfizer or Moderna) or two weeks since a single-dose vaccine (e.g. Johnson & Johnson) has been administered. Absent a qualifying exemption, all GRAIL US employees are to comply with this requirement, including providing documentation of such vaccination status, as a condition of employment. Anyone unable to be vaccinated, either because of a sincerely held religious belief or a medical condition or disability that prevents them from being vaccinated, can request a reasonable accommodation for consideration by GRAIL.

GRAIL Glassdoor Company Review

3.9