Principal Scientist I, Cellular/Functional Biology

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok.

Discovery Biotherapeutics and Genetic Medicine (BGM) at Abbvie is seeking a highly motivated Principal Research Scientist to join the Cell and Functional Biology group at the AbbVie Bioresearch Center (ABC) site based in Worcester, MA.  This role will be responsible for the design and execution of screening strategies employed to advance promising biotherapeutics from early exploration through lead optimization.  Close partnerships with cross-functional colleagues will be required to drive transformative ideas to the clinic. The ideal candidate should possess experience in large molecule screening strategy design including vitro cell-based assays, with a strong experience in functional assay development and high-throughput screening.

Job Responsibilities:

• Develop in vitro functional assays leveraging diverse signaling pathways to transition early therapeutic ideas into enabled biotherapeutics campaigns.
• Design and employ strategic screening funnels for biotherapeutic discovery campaigns, performing detailed analysis of complex data sets for key insights guiding decision-making processes in research projects.
• Identify and integrate cutting-edge technologies and methodologies into screening and assay development, anticipating future trends in drug discovery.
• Foster strong cross-functional collaborations with therapeutic area partners to promote the generation of innovative ideas and solutions which support organizational objectives.
• Present and explain research findings and strategies clearly and effectively, preparing scientific reports, publications, and presentations for varied audiences.
• Demonstrate scientific excellence through dedication to multiple projects in a fast-paced multi-disciplinary environment.

• BS with 14+ years of experience or MS with 12+ years of experience or PhD +6 years of experience in Biology, Molecular and Cellular Biology, or another related field.
• Extensive experience in biotherapeutic discovery and screening.
• Demonstrated ability to inspire team members to achieve their best performance, fostering a positive and productive team environment.
• Proficiency in developing and optimizing high-throughput screening assays for biotherapeutic candidates, including cellular and immunoassays.
• Demonstrated ability to lead cross-functional research teams, manage projects, and effectively communicate with stakeholders.
• Experience with state-of-the-art screening technologies and data analysis tools.

Desirable:

• Experience with HTS and enabling automation platforms
• Experience in managing relationships with Contract Research Organizations (CROs) and external partners.
• Experience with enterprise data capture solutions (GeneData, Dotmatics, Benchling)

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.​

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​

• This job is eligible to participate in our short-term incentive programs. ​

• This job is eligible to participate in our long-term incentive programs​

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Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. 

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion.  It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.

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