Sr. Scientist I Biologics Discovery Antibody Engineering

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok.

The Biologics and Genetic Medicine group at AbbVie Bay Area is seeking a highly motivated Senior Scientist to join a dynamic team supporting Biologics drug discovery. This position will impact projects through the discovery and engineering of biopharmaceutical products. The ideal candidate should have direct experience with molecular techniques and binding assays (e.g., ELISA or Octet), in vitro display technologies (e.g, phage display, yeast display), experience with antibody engineering, and familiarity with sequence analysis tools and molecular modeling software. The applicant should be highly autonomous—conceiving and implementing novel experimental approaches to answer scientific questions. She/he should possess excellent communication skills and be comfortable serving as Biologics Lead in project team settings.

Responsibilities

• Lead from the lab by executing antibody phage library panning and yeast display for antibody discovery and engineering campaigns
• Design, execute, and troubleshoot molecular biology workflows
• Stay abreast of current literature to continuously innovate and optimize existing workflows
• Serve as Biologics Lead in project team meetings: effectively partner with functional and therapeutic areas to achieve project objectives

• Bachelor’s Degree or equivalent education and typically 10 years of experience, Master’s Degree or equivalent education and typically 8 years of experience, PhD and no experience necessary
• Demonstrated ability to use and design in vitro antibody discovery display technologies (e.g., phage, yeast display) for discovery and/or engineering
• Experience in antibody engineering and optimization (e.g., humanization, affinity maturation)
• Strong molecular biology skills: PCR, DNA/RNA isolation, plasmid prep, gel extraction, cloning
• Direct experience with ELISA binding assays
• Sanger sequence analysis experience
• Understanding of protein structure and function
• Excellent organizational skills and the ability to manage multiple projects simultaneously
• Team player with the ability to operate in a fast-paced multi-disciplinary environment
• Adapt to rapid changes in project priorities and timelines
• Competency with MS Excel, Powerpoint, Word

Preferred:

• Direct experience with Octet BLI and flow cytometry
• Knowledgeable in recombinant protein production and characterization
• Proficiency in GraphPad Prism, Geneious, and Genedata
• Structure-based molecular modeling and applications with AI/ML and integrating complex datasets to drive data-based decisions

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​​

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• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.​​

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​​

• This job is eligible to participate in our short-term incentive programs. ​​

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Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. 

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion.  It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.

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