Senior Process Development Engineer I – Downstream Process Development

As a Senior Process Development Engineer I at Debut, your primary responsibilities will include carrying out bench-scale studies to optimize small molecule purification processes, designing and executing experiments, documenting findings in detailed reports and presentations, and collaborating cross-functionally with various teams to ensure effective implementation of processes. You'll be a problem-solver, utilizing your creativity and engineering knowledge to develop strategies for enhancing process performance.

To apply for the Senior Process Development Engineer I role at Debut, candidates should hold a Bachelor’s degree in Chemical Engineering or a related scientific field, with 6-7 years of industrial experience, or an MS with 3-5 years, or a PhD with 0-2 years. Relevant experience in downstream process development, particularly in small molecule purification, and familiarity with unit operations such as centrifugation and crystallization are highly desirable.

At Debut, the work environment for the Senior Process Development Engineer I is dynamic and collaborative. You will be working in a state-of-the-art laboratory that supports innovative biotechnology projects. Team members engage in fast-paced interactions, fostering creativity and problem-solving skills while staying focused on sustainability and excellence in process development.

The Senior Process Development Engineer I will be part of the downstream process development team, working closely with fermentation scientists, chemists, pilot plant associates, and engineers. Collaboration is pivotal at Debut, as this role involves cross-functional teamwork to ensure smooth transitions from research to production while maintaining consistency in standard operating procedures.

The salary range for a Senior Process Development Engineer I at Debut is between $100,000 and $130,000 per year. Compensation may vary based on experience and qualifications, reflecting our commitment to attracting talented individuals passionate about biotechnology and sustainable practices.

When designing experiments for downstream process development, it's essential to define the objectives clearly, identify the critical process variables, and ensure comprehensive data tracking. Use statistical methods to plan your experimental protocols, which can help in optimizing yields and enhancing reproducibility. Always be prepared to iterate based on early results.

In my previous roles, I've utilized various purification technologies such as centrifugation, filtration, liquid-liquid extraction, and crystallization extensively. I'm familiar with the operational principles and can troubleshoot issues that may arise during these processes, ensuring optimal yield and quality of end products.

Scaling up processes often comes with challenges like maintaining product quality or handling variances in raw materials. To address these, I've focused on thorough documentation and validation at each stage, utilizing pilot studies to anticipate potential issues. Collaboration with cross-functional teams also aids in ensuring that all perspectives are integrated into the scaling strategy.

I ensure accurate documentation by maintaining detailed lab notebooks, adhering to SOPs, and using electronic data management systems when available. Each entry is made contemporaneously and includes observations, procedures, and results, which ensures reproducibility. Regular reviews and edits keep the documentation clear and comprehensive.

I have solid experience using statistical analysis software like JMP to analyze process data, assess variability, and perform regression analysis. This enables me to interpret data effectively, which plays a crucial role in decision-making and optimizing process parameters.

I am deeply motivated by the potential of biotechnology to create sustainable solutions. The challenge of developing efficient purification processes for biologically-derived materials fuels my curiosity and drive, knowing that our work contributes to healthier consumer products positively impacting lives.

My communication style is tailored to the audience; I focus on clarity and engagement. When presenting technical information, I use visuals and examples to make complex concepts accessible and relatable. Providing context and inviting questions helps ensure effective knowledge transfer.

I regularly read scientific journals, attend relevant conferences, and participate in professional networks to stay updated on biotechnology and process engineering advancements. Continuous learning helps me incorporate new methodologies and technologies into my work effectively.

In one project, we faced unexpected low yields during the purification phase. After gathering data and analyzing the variables, I identified a sub-optimal filtration method. By redesigning the process using a hybrid approach, we improved yields significantly and met project deadlines. This experience taught me the value of rigorous analysis and adaptability.

When working under tight deadlines, I prioritize tasks by assessing their impact on project milestones. I use checklists and timelines to stay organized, focusing on critical path tasks first. Regular communication with my team helps ensure we stay aligned and meet our goals effectively.