Research Scientist, Cell Biology – CAR-T Therapy Process Development

Job Description

At Gilead we believe every employee deserves a great leader. As a people leader now or in the future, we expect that you will model and create an environment of inclusion, be intentionally focused on the hiring, development, growth and retention of talent, and empower teams to align and achieve goals.

Job Description

Kite is a biopharmaceutical company engaged in the development of innovative cancer immunotherapies with a goal of providing rapid, long-term long-lasting response and eliminating the burden of chronic care. The company is focused on chimeric antigen receptor (CAR) and T cell receptor (TCR) engineered cell therapies designed to empower the immune system's ability to recognize and kill tumors.

The preclinical process development team is seeking a highly motivated Research Scientist to join the group. The preclinical process development team sits within Research and partners with cross-functional teams to develop innovative CAR-T therapy for treating patients. Specifically, this team is accountable for developing fit-for-purpose and stage-appropriate T cell therapy bioprocess and plays a key role in advancing pipeline candidates. Current pipelines include autologous and allogeneic cell therapies which apply novel manufacturing approaches and pioneering technologies.

Responsibilities:

The exceptional and motivated candidate will join the group in a key role. The Research Scientist will lead the effort for developing T cell bioprocess to advance pipeline candidates using emerging and innovative approaches, process characterization, and technology transfer partnering with cross-functional teams.

• Lead efforts to develop and optimize process parameters towards several T cell manufacturing platforms, focusing on in-process metabolic modulation and media supplement/cytokine development, to deliver potent and long lasting CAR-T cell therapy
• Play a key role in T cell bioprocess development initiatives to enable stage-appropriate process development and characterization, utilizing novel process analytical technologies (PAT) and bioreactor systems
• Work in close collaboration with cross-functional teams for pipeline candidate advancement
• Develop fit-for-purpose assays to characterize process parameter-driven T cell immuno- and energy metabolic phenotypes to inform T cell potency and persistency
• Mentor junior scientist in informal setting
• Communicate plans and scientific results in both oral and written form
• Coordination of tasks across multiple projects, demonstrating prioritization and planning, managing timelines and deliverables
• Keep electronic notebook and batch record.

Basic Qualifications:

• Doctorate OR
• Master’s and 6+ years of scientific experience OR
• Bachelor’s and 8+ years of scientific experience OR
• Associate and 10+ years of scientific experience OR
• High School Diploma/GED and 12+ years of scientific experience

Preferred Qualifications:

• Experience with development of unit operations applicable in the manufacturing of genetically engineered T cell-based therapy
• Advanced cell culture techniques with preference for human T cell or other immune cell types
• Proficient in utilizing analytical methods characterizing and understanding cell therapy product
• In-depth understanding of immune metabolism
• Knowledge of state-of-art cell therapy bioprocess technologies
• Proficiency in operating closed systems in cell therapy manufacturing
• Demonstrated achievement to be self-motivated, creative, and work both independently and within a highly adaptable team environment
• Comfortable in a exciting company and able to adjust workload based upon changing priorities
• Thorough organizational skills and record keeping
• Excellent interpersonal, verbal and written communication skills in a collaborative work environment

Does this sound like you? If so, apply today!

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The salary range for this position is: $149,600.00 - $193,600.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans*.

For additional benefits information, visit:

https://www.gilead.com/careers/compensation-benefits-and-wellbeing

• Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans.

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