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Scientist

Scholar Rock is a biopharmaceutical company that discovers, develops, and delivers life-changing therapies for people with serious diseases that have high unmet need. As a global leader in the biology of the transforming growth factor beta (TGFβ) superfamily of cell proteins and named for the visual resemblance of a scholar rock to protein structures, the clinical-stage company is focused on advancing innovative treatments where protein growth factors are fundamental. Over the past decade, the company has created a pipeline with the potential to advance the standard of care for neuromuscular disease, cardiometabolic disorders, cancer, and other conditions where growth factor-targeted drugs can play a transformational role.

 

Scholar Rock is the only company to show clinical proof of concept for a muscle-targeted treatment in spinal muscular atrophy (SMA). This commitment to unlocking fundamentally different therapeutic approaches is powered by broad application of a proprietary platform, which has developed novel monoclonal antibodies to modulate protein growth factors with extraordinary selectivity. By harnessing cutting-edge science in disease spaces that are historically under-addressed through traditional therapies, Scholar Rock works every day to create new possibilities for patients. Learn more about the company’s approach at ScholarRock.com and follow @ScholarRock and on LinkedIn.


Summary of Position:


Scholar Rock is seeking an outstanding individual to play a key role in the discovery and development of novel biotherapeutics.  The successful candidate will join the Antibody Engineering group to discover, express, purify, and characterize antibodies and other biologic modalities to support multiple discovery programs.


Position Responsibilities:
  • Utilize a proprietary in-house phage display platform to discover novel candidate antibodies
  • Design antigens and potential therapeutic molecules and engineer lead candidates
  • Conduct experiments to evaluate the 'drug-like' quality of candidate antibodies
  • Perform Octet, Biacore, and ELISA experiments to evaluate the binding profile and affinity of lead molecules
  • Evaluate and implement new technologies for efficient and high-throughput screening of antibodies and antibody fragments
  • Perform purification of antibodies and other proteins at various production scales
  • Maintain detailed records of experimental protocols and data in laboratory notebooks in accordance with company policy
  • Analyze, interpret, report, and present experimental results


Candidate Requirements:
  • Ph.D. in molecular biology, biochemistry, or related field with 0-1 year of industry experience or BS/MS with comparable pharmaceutical industry experience 
  • Experience engineering antibodies and/or peptides preferred
  • Strong written and verbal communication skills
  • The individual should be able to function in a timeline-driven, dynamic environment, and be able to rapidly adapt to new techniques and protocols
  • The successful candidate should have the ability to work both independently and as part of a team to meet deadlines and contribute to the strategic goals of the company
  • Flexibility to work in a matrixed research organization
  • A strong work ethic and high-level of motivation are required


Scholar Rock is an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees

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Average salary estimate

$72500 / YEARLY (est.)
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$60000K
$85000K

If an employer mentions a salary or salary range on their job, we display it as an "Employer Estimate". If a job has no salary data, Rise displays an estimate if available.

What You Should Know About Scientist, Scholar Rock

If you are passionate about advancing novel biotherapeutics, Scholar Rock in Cambridge, MA is looking for a dynamic Scientist to join our Antibody Engineering group. As a clinical-stage biopharmaceutical company, we are at the frontier of discovering transformative therapies for serious diseases, including neuromuscular diseases and cancer. This is your chance to leverage your Ph.D. in molecular biology or biochemistry to make a meaningful impact. In this role, you'll utilize our proprietary phage display platform to uncover innovative antibody candidates, design therapeutic molecules, and conduct experiments that evaluate 'drug-like' qualities of these candidates. You'll get hands-on experience with advanced techniques, including Octet and ELISA, while also exploring new technologies to enhance our high-throughput screening processes. At Scholar Rock, we strongly believe in teamwork and fostering an inclusive environment, and your communication skills will help bridge collaboration within our research organization. Your ability to adapt to new techniques is vital as we strive to meet our strategic goals together. Join us in driving the science forward and creating new possibilities for patients in need.

Frequently Asked Questions (FAQs) for Scientist Role at Scholar Rock
What are the responsibilities of a Scientist at Scholar Rock?

As a Scientist at Scholar Rock, you'll have a pivotal role in the discovery and development of biotherapeutics. Your responsibilities will include utilizing our specialized phage display platform, designing antigens and therapeutic molecules, and performing a variety of experiments to assess the qualities of candidate antibodies. You'll also engage in purifying antibodies and proteins while maintaining meticulous records of your work, all crucial to advancing our innovative projects.

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What qualifications are needed to become a Scientist at Scholar Rock?

To qualify for the Scientist position at Scholar Rock, you should hold a Ph.D. in molecular biology, biochemistry, or a related field, along with 0-1 year of relevant industry experience. Alternatively, a BS/MS in a comparable field with practical experience is also accepted. Experience in antibody engineering or peptide work is highly preferred, and strong communication skills are essential for effective collaboration in this role.

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What type of environment does a Scientist at Scholar Rock work in?

A Scientist at Scholar Rock works in a dynamic, timeline-driven environment where adaptability is key. You will collaborate within a matrixed research organization, which requires strong teamwork and communication skills. Scholars Rocks' commitment to innovation means you will be encouraged to explore new techniques and protocols, enhancing both your professional growth and our therapeutic advancements.

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How does the Scientist role contribute to Scholar Rock's mission?

The Scientist role is vital to Scholar Rock's mission of developing life-changing therapies for patients with serious diseases. By discovering and engineering novel biotherapeutics, you'll directly contribute to the pipeline of transformative treatments, particularly in areas that have historically been under-addressed. Your work will help ensure that groundbreaking therapies are delivered to those in need.

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What skills and attributes are beneficial for a Scientist at Scholar Rock?

For a Scientist at Scholar Rock, having a strong work ethic and motivation is crucial, alongside technical expertise in molecular biology and biochemistry. Effective written and verbal communication skills will aid in collaborating with team members, while flexibility and the ability to thrive in a fast-paced environment will help you meet the company's strategic goals effectively.

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Common Interview Questions for Scientist
Can you describe your experience with antibody engineering?

When discussing your experience with antibody engineering, focus on specific projects where you've designed or optimized antibodies. Include details about the techniques you used, such as phage display or other methods, and emphasize outcomes, such as increased affinity or specificity of the antibodies. Highlight your role and contributions as a team player in these endeavors.

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How do you approach problem-solving in a fast-paced laboratory environment?

In fast-paced laboratory settings, I approach problem-solving by first addressing the challenges analytically and prioritizing tasks based on urgency and impact. I maintain clear communication with my team to ensure alignment on methods and expectations while being open to feedback. I also set aside time for regular evaluations of progress, allowing for adjustments when necessary.

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What techniques do you use to assess the binding affinity of antibodies?

To assess binding affinity, I typically use techniques like Biacore and Octet. These methods provide real-time interaction analysis between antibodies and their antigens, allowing for quantifiable data on binding kinetics. I would explain a specific instance where I applied these techniques, outlining the results and their importance to the project's goals.

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Describe your experience with high-throughput screening technologies.

I have hands-on experience with high-throughput screening technologies, particularly in antibody discovery and characterization. I employed various platforms to efficiently test multiple candidates, which significantly accelerated our discovery timelines. I would discuss specific examples where I contributed to the optimization of processes, leading to increased success rates in identifying viable candidates.

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How do you maintain accurate records of your experiments?

Maintaining accurate records is essential to scientific integrity. I keep detailed laboratory notebooks that include experimental protocols, data, and observations. I follow strict protocols for documentation to ensure reproducibility. Additionally, I periodically review my notes to confirm accuracy and completeness, which helps in forthcoming analyses and presentations.

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What motivates you to work in biopharmaceutical research?

My motivation in biopharmaceutical research stems from the desire to impact patients' lives positively. I find it rewarding to work on innovative therapies that have the potential to address unmet needs in healthcare. The challenge of translating scientific discoveries into practical therapies drives me, and I am passionate about being part of a collaborative team focused on this goal.

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Explain how you handle feedback in a collaborative environment.

I view feedback as an opportunity for growth and improvement. When receiving feedback, I actively listen and ask clarifying questions to ensure I understand the points being raised. I seek to incorporate constructive feedback into my work, adjusting my approach as necessary, and I also provide supportive feedback to teammates to foster a collaborative atmosphere.

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Can you share a time you adapted to a new technique quickly?

Certainly! There was a time when I needed to adapt a new protein expression system. I dedicated extra hours to understanding the methodology, including attending workshops and collaborating with experienced colleagues. By immersing myself in the subject matter, I quickly became proficient in using this new system, which ultimately contributed to the efficiency of our research projects.

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How do you prioritize tasks in a busy research setting?

In a busy research setting, I prioritize tasks based on deadlines, project goals, and the overall impact on team objectives. I use tools like to-do lists and project management software to visualize my workload and ensure transparency with my team. Regular check-ins also help me align priorities with evolving project demands.

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What do you consider the most significant challenge in biopharmaceutical research?

One major challenge in biopharmaceutical research is navigating the complexity of human biology and disease mechanisms. Success often requires iterative processes and careful optimization. I believe that thorough scientific investigation, collaboration, and adaptability are crucial to overcoming obstacles and achieving breakthroughs in developing effective therapies.

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Relentlessly focused on seeing new possibilities in deep structural insights, validated biologies and antibody technologies to allow us to move with speed and urgency to deliver high-impact medicines to patients with devastating diseases.

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Full-time, on-site
DATE POSTED
January 7, 2025

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