Job details

Process Development Scientist

GIVAX is a Venture Capital-backed biotech company founded through RA Ventures’ incubator. GIVAX is utilizing a novel vector-based vaccine platform to address unmet public health needs in the prevention of infectious gastrointestinal diseases.

SUMMARY:

We are seeking an energetic and motivated scientist to join GIVAX. In this role, you will be part of a team that is working on the molecular biology and immune evaluation of viral vector backbones and candidate vaccine viruses. As a Process Development Scientist, you will be responsible for supporting the team in moving the vaccine/s into clinical ready products for Phase 1 and beyond. You will have the opportunity to work with some of the world’s leading scientists in the field of vaccine development to bring our flagship program from discovery to industrialization. We are seeking an innovative mind with expertise in viral molecular biology and particularly reverse genetics technology.

Leveraging previously acquired academic and/or work experience, the Process Development Scientist will be responsible for development of a small-scale manufacturing process, formulation development and development of methods to characterize the product and process. The incumbent will report to the Technical Project Lead and will also work in close collaboration with the Head of Operations. In addition to the internal staff, the incumbent will work in close collaboration and key partners to plan and execute the research that will lead to the generation of our vaccine candidates.

RESPONSIBILITIES

Please note: The percentages listed below are related to the expected effort distribution for this role.

Laboratory Research (70%)

Develop small-scale manufacturing process based on licensed live attenuated rotavirus vaccines, optimized for maximized yield and recovery.
Source and test animal origin free, chemically defined reagents to use in manufacturing process.
Execute process development experiments to support process definition.
Plan and run experiments to select best formulation based on licensed LAV rotavirus vaccines.
Develop methods to characterize the process, drug substance and drug product.
Generate tech transfer package to support hand-off to CDMO to produce clinical material.
Interact with CRO/CDMO team members, and other SMEs as dictated by project needs.
Ensure that work is performed following current, phase-appropriate regulatory and quality compliance requirements.
Maintain knowledge of new scientific literature directly related to GIVAX programmatic priorities.

Project Management (15%)

In collaboration with Vaccine Project Head, create and monitor experimental plans, cost estimations, schedule, and resourcing plan
Engage with external partners and other SMEs as dictated by project needs
Monitor key milestones, decision points, and critical path activities associated with his/her function to ensure timely achievement of project deliverables.
Identify and assess risks and roadblocks, and develop mitigation plans to address risks

Internal Affairs (15%)

Provide support to Senior Leadership to achieve the company mission.
Interact with colleagues transparently and cooperatively, contributing to an open exchange of ideas among team members.
Ensure efficient and agile communication of key information, processes, workflows, and operational elements in various circumstances.

POSITION DETAILS

Hands-on lab role
Reports to the Vaccine Project Head
Title will commiserate experience
Location: Philadelphia, PA

EDUCATION LEVEL

PhD in life science discipline or equivalent years’ experience required
Authorization to work in the United States required

BASIC QUALIFICATIONS

PhD in a life science discipline with >1 year of postdoctoral experience
Scientific publications in virology
Minimum 5 years of experience in basic research

PREFERRED QUALIFICATIONS

Experience working in process development for live attenuated viral vaccines
Experience in working with infectious diseases (BSL2 or above)
Working knowledge of virology, immunology, molecular biology, and protein chemistry.
Experience in vaccine early- and/or late-stage development and manufacturing.
Ability to work in cross-functional teams effectively and to build strong relationships with partners.
Ability to work independently and take personal initiative to complete tasks.
Strong organizational/time management skills and ability prioritize tasks.
Flexibility and willingness to support the team in execution of project goals.
Excellent written and oral communication skills, fluency in English (written and spoken).

Average salary estimate

$85000 / YEARLY (est.)

min

max

$70000K

$100000K

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What You Should Know About Process Development Scientist, GIVAX

At GIVAX, a dynamic Venture Capital-backed biotech company located in the heart of Philadelphia, PA, we're on a mission to tackle public health challenges through innovative vaccine solutions. We're looking for a passionate and dedicated Process Development Scientist to become an integral part of our team. In this role, you'll dive into the exciting world of molecular biology and contribute to the development of viral vector vaccines aimed at infectious gastrointestinal diseases. Collaborating closely with leading scientists, you'll translate research into clinical-ready products, focusing on small-scale manufacturing processes, formulation development, and product characterization. With your expertise in viral molecular biology and reverse genetics technology, you'll lead experiments designed to maximize yield and recovery, ensuring compliance with regulatory and quality standards. Not only will you engage in hands-on lab research, but you'll also play a crucial role in project management by strategizing experimental plans and collaborating with external partners. If you thrive in a fast-paced, innovative environment and are ready to make a significant impact in vaccine development, we would love to hear from you. Join us at GIVAX and help shape the future of public health with your scientific prowess!

Frequently Asked Questions (FAQs) for Process Development Scientist Role at GIVAX

What are the key responsibilities of a Process Development Scientist at GIVAX?

As a Process Development Scientist at GIVAX, you'll primarily focus on developing small-scale manufacturing processes for our viral vector vaccines. Your responsibilities will include conducting laboratory research, optimizing yield, sourcing reagents, running process development experiments, and generating tech transfer packages for clinical material production. You'll also support project management by engaging with stakeholders and monitoring project milestones.