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Postdoctoral Scholar

Department Overview

The Gupta lab at the Department of Chemical Physiology and Biochemistry, Oregon Health and Science University (OHSU), Portland, Oregon is exploring membrane proteins and protein-protein interactions involved in various human diseases. We use biochemistry, structural biology, and cell biology tools to assess role of proteins of interest. We are seeking a highly motivated postdoctoral candidate with demonstrated training and research experience in protein biochemistry and molecular biology.

 

A competitive candidate would be a recent Ph.D. graduate with good publication record. The position involves the candidate to review scientific literature, propose hypothesis, design experiments, interpret results, and write manuscripts. We have an interdisciplinary research program that requires working in collaboration within the lab and with other research groups. Applicants must be highly independent, driven, and value working in teams, with proven project management and leadership success.

 

To apply, please send a brief cover letter about your interest in the position and your research experiences/interests, a CV, and names and contact information for 3 professional references at guptame@ohsu.edu.

Function/Duties of Position

  • Design and conduct biochemical and biophysical experiments to investigate structure-dynamics-function relationships of various integral membrane proteins. 
  • Cell culture, protein expression using various expression systems, purification, sample preparation for cryoEM/cryoET/X ray crystallography, data collection, data analysis, model building, functional assays, data interpretation. 
  • Record keeping, documentation and presentations:
    • Maintain accurate and detailed records of all experimental procedures, data collection and analysis performed and share it on a regular basis with the PI.
    • Strong written and oral communication skills for reporting experimental results, writing manuscripts, presenting research findings at lab meetings.
    • Assist the PI with manuscript preparation and grant applications as well as apply for independent funding opportunities.
    • Present, or assist in the presentation of, research projects at retreats, seminars, conferences and other OHSU or public venues.
    • Maintain high level of professional expertise through familiarity with current scientific literature. Participate in professional development opportunities. 
  • Assist in lab management, training of new lab personnel on lab practices and protocols, including sample preparation and instrumentation use.
  • Perform routine lab operations, including but not limited to the purchase of laboratory supplies, monitoring supplies, and maintaining assigned laboratory equipment.
  • Maintain laboratory compliance documentation for biological, and radiological work. Be familiar with lab safety infrastructure and ensure compliance with all safety regulations. 
  • Other responsibilities as assigned by the supervisor in furtherance of the lab’s research and the university’s missions and goals of teaching, research, outreach, and public service. 

Required Qualifications

  • Ph.D. in Biochemistry or related field

  • Research experience in the fields of protein biochemistry, molecular biology, biophysics

  • Efficient in literature review, experiment design, planning, and organizing

  • Molecular biology tools (e.g., gel electrophoresis, PCR, cloning)

  • Protein analysis tools like Western blotting, immunoprecipitation

  • Basic knowledge of DNA and protein analysis software tools

  • Protein expression and purification

  • Problem solving skills and research integrity

  • Ability to adapt to newer methods/tools as required by the research projects

  • Strong communication skills in both oral and written formats

  • Working knowledge of office computer applications, such as Word, Excel and PowerPoint

Preferred Qualifications

  • Ph.D. in Structural biology of integral membrane proteins
  • Additional research experience in the field of structural biology (e.g., cryoEM, X-ray crystallography and/or NMR)
  • Integral membrane protein expression and purification in insect and mammalian cell lines

  • Biochemical/Biophysical characterization methods

  • Cell culture techniques

  • Computational skills (e.g., familiarity with cryoEM data processing pipeline, linux/python)

  • Advanced knowledge of tools like GraphPad Prism, Adobe Illustrator

Additional Details

Individuals are expected to work on-site to conduct laboratory research, handling chemical and biological reagents, manual and automated equipment. The schedule will be planned according to the research project and experimental needs. On-site work is generally expected 40 hours per week between 8am to 6pm. However, working flexible hours after 6 pm or on weekend may be required occasionally depending on the ongoing experiments. Additional safety training will be required to work with cell lines/ infectious bacteria or viruses/ working with in a BSL-2 environment.

All are welcome

Oregon Health & Science University values a diverse and culturally competent workforce. We are proud of our commitment to being an equal opportunity, affirmative action organization that does not discriminate against applicants on the basis of any protected class status, including disability status and protected veteran status. Individuals with diverse backgrounds and those who promote diversity and a culture of inclusion are encouraged to apply. To request reasonable accommodation contact the Affirmative Action and Equal Opportunity Department at 503-494-5148 or aaeo@ohsu.edu.

Average salary estimate

$60000 / YEARLY (est.)
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$50000K
$70000K

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What You Should Know About Postdoctoral Scholar, Oregon Health & Science University

The Gupta lab at the Oregon Health and Science University (OHSU) in Portland is on the hunt for a dedicated Postdoctoral Scholar to join our interdisciplinary team! If you're passionate about diving into the fascinating world of membrane proteins and their roles in human diseases, then this is the perfect opportunity for you. As a Postdoctoral Scholar, you will design and conduct experiments that explore the structure-dynamics-function relationships of integral membrane proteins using advanced techniques. Your projects will include cell culture, protein expression, purification, and cutting-edge methods such as cryoEM and X-ray crystallography. We value collaboration and expect you to work alongside other researchers while maintaining detailed documentation of your findings. Not only will you share results at lab meetings and assist in writing manuscripts, but you will also have the chance to contribute to grant applications and pursue independent funding opportunities. This role calls for a Ph.D. in Biochemistry or a related field, along with research experience in protein biochemistry and molecular biology. Your strong problem-solving skills and effective communication are crucial as you'll be training new lab personnel and providing support in lab management. We believe in a culture of inclusion and welcome applicants from diverse backgrounds. If you're a self-driven, independent thinker ready to make an impact in scientific research, we invite you to apply and be a part of our innovative lab!

Frequently Asked Questions (FAQs) for Postdoctoral Scholar Role at Oregon Health & Science University
What are the responsibilities of a Postdoctoral Scholar at OHSU?

As a Postdoctoral Scholar at Oregon Health and Science University (OHSU), your primary responsibilities will include designing and conducting experiments to study membrane proteins, maintaining accurate records of all procedures and data, assisting in manuscript preparation, and collaborating with both lab members and external research groups. You'll also be involved in presenting research findings and ensuring compliance with safety regulations in the lab.

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What qualifications are required for the Postdoctoral Scholar role at OHSU?

To qualify for the Postdoctoral Scholar position at Oregon Health and Science University (OHSU), candidates must possess a Ph.D. in Biochemistry or a closely related field, alongside research experience in protein biochemistry and molecular biology. Proficiency in experiment design and molecular biology tools such as gel electrophoresis and PCR is essential, as well as strong problem-solving skills and effective communication abilities.

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What skills are preferred for the Postdoctoral Scholar position at OHSU?

While the essential qualifications for the Postdoctoral Scholar role at Oregon Health and Science University (OHSU) include a Ph.D. in a relevant field, preferred skills involve experience in structural biology, such as cryoEM or X-ray crystallography. Knowledge in computational tools like Python or familiarity with software for data analysis will also enhance your candidacy for this exciting role.

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How does OHSU support diversity in the Postdoctoral Scholar role?

Oregon Health and Science University (OHSU) is committed to fostering a diverse and culturally competent workforce. The organization actively encourages applicants from diverse backgrounds to apply for the Postdoctoral Scholar position and promotes a culture of inclusion within its research teams. OHSU also has resources available to provide reasonable accommodations for applicants as needed.

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What is the work environment like for the Postdoctoral Scholar at OHSU?

The work environment for a Postdoctoral Scholar at Oregon Health and Science University (OHSU) emphasizes collaboration, innovation, and professional growth. Scholars are expected to engage in laboratory research and handle various biochemical and biophysical tasks, often working on-site for approximately 40 hours a week, with flexibility for evening or weekend work as necessary. This dynamic setting fosters teamwork and creativity in advancing scientific knowledge.

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Common Interview Questions for Postdoctoral Scholar
Can you describe your experience with protein biochemistry techniques relevant to the Postdoctoral Scholar position?

When responding to this question, highlight specific techniques you've used, such as protein expression, purification processes, and methods like Western blotting or immunoprecipitation. Explain how you applied these techniques in your previous research, including any challenges you faced and how you overcame them to achieve your results.

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What is your approach to designing experiments in molecular biology?

Discuss your systematic process for designing experiments, including conducting literature reviews, formulating hypotheses, and selecting appropriate methodologies. Mention how you analyze preliminary data and adjust your approach based on findings to ensure robustness in results.

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How do you maintain accurate records of your research?

Emphasize the importance of meticulous record-keeping in scientific research. Share your methods for documenting procedures, data collection, and analysis, ensuring they are clear and easily accessible to collaborators, which fosters teamwork in projects.

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Describe how you handle project management and leadership in research.

Provide examples of how you've led projects, coordinated with team members, and managed time effectively. Highlight your ability to delegate tasks, motivate team members, and navigate challenges while staying on track with project timelines.

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How have you communicated complex scientific information to various audiences?

Share your experiences in presenting research findings to diverse audiences, such as at conferences or lab meetings. Discuss your strategies for tailoring your communication style to suit the audience's knowledge level and how you use visual aids and clear language to enhance understanding.

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What methods do you utilize to stay updated on scientific advancements in your field?

Explain how you keep current with literature, attend seminars, and participate in professional development opportunities. Mention specific journals or conferences you follow, and any collaborations that enrich your understanding of emerging research trends.

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Can you discuss your experience with grant applications and funding proposals?

When addressing this question, talk about any prior involvement you have had in writing grant applications or assisting supervisors in preparing proposals. Cover aspects like your role in outlining research plans, budgeting, and ensuring comprehensive documentation to support funding requests.

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What challenges have you faced in your research, and how did you overcome them?

Be prepared to elaborate on specific challenges you've encountered, whether technical difficulties or issues with collaboration. Discuss your problem-solving approach and how you leveraged resources or sought help to find solutions, ultimately driving your research forward.

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How do you ensure compliance with safety regulations in the lab?

Your answer should emphasize the significance of adhering to safety protocols. Share practices you follow to maintain lab safety, such as proper handling of reagents, maintaining equipment, and ensuring that all personnel are educated about safety regulations and compliance.

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What motivates you as a researcher in the field of biochemistry?

Discuss your passion for biochemistry and what drives your research interests. Whether it's the quest for knowledge, making a difference in human health, or the thrill of scientific discovery, share personal anecdotes that depict your enthusiasm and commitment to the field.

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Full-time, on-site
DATE POSTED
April 8, 2025

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