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Bioinformatics Data Engineer

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.The Opportunity:In this role, you will work within our Translational Medicine group transferring, organizing, curating and disseminating biomarker data from clinical trial samples. This incoming data consists of a diverse mix of next-generation sequencing, downstream variant calls, imaging, and other molecular assay outputs. The bioinformatics data engineer will work on various projects in different phases of drug development and contribute to the cross-functional bioinformatics team which includes other bioinformaticians and data scientists. As a Bioinformatics Data Engineer in Translational Medicine, you will:• Act as a main liaison between internal scientists and external molecular diagnostic providers.• Be the primary point of contact for the data transfer process, establishing connections between our cloud storage and external file shares.• Help develop scripts and processes to clean, upload and accession biomarker data from clinical trails into internal systems for further analysis.• Carry out data modeling and curation to ensure data quality and relevance.• Collaborate with other departments to share and disseminate data in a controlled and documented manner.• Develop web-based data visualization dashboards using python and R frameworks.• Use and modify data analysis pipelines using nextflow and WDL.Required Experience, Skills, and Education:• Master’s or bachelor’s degree with 3+ years’ experience in biology/computer science related field.• Expertise using linux clusters, cloud computing and file systems.• Proficient in designing and querying databases using SQL and object-relational mapping techniques.• Skilled in utilizing Python and R for data manipulation and analysis.• Strong familiarity with bioinformatics data types and outputs.• Excellent communication skills, enabling effective collaboration and conveying technical information clearly to diverse audiences.Preferred Experience, Skills, and Education:• Experience using visualization packages such as R Shiny, PowerBI or similar systems.• Experience in biomarker data analysis and bioinformatics.• Familiarity with large genomic data sets (GDC, TCGA, etc.).• Experience in tools to analyze cancer genomics datasets (GATK, Salmon, OncoKB, VEP, etc.).• Development experience in groups using IDE’s, a ticketing system and software control systems (GIT).The expected salary range for this role is $120,000 to $145,000. An individual’s position within the range may be influenced by multiple factors, including skills and experience in role, overall performance, individual impact and contributions, tenure, and market dynamics. Base salary is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com.

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What You Should Know About Bioinformatics Data Engineer, Revolution Medicines

As a Bioinformatics Data Engineer at Revolution Medicines, based in Redwood City, CA, you will be at the forefront of innovation in precision oncology. Your role is vital in ensuring that the biomarker data from clinical trials is properly transferred and organized, allowing our talented Translational Medicine team to turn this information into breakthroughs for patients battling RAS-addicted cancers. You will collaborate closely with scientists and external molecular diagnostic providers, serving as the linchpin for data management and quality assurance. Your technical expertise in Python and R will come into play as you develop web-based data visualization dashboards, making complex data easy to grasp for your colleagues. You'll find yourself utilizing cloud storage solutions to streamline the data transfer process and using SQL for effective database management. With three or more years of experience in the biology or computer science fields, your background will position you to excel in this dynamic environment. Revolution Medicines is all about growth; we provide opportunities for you to advance your skills while contributing to the fight against cancer. Your work here will directly impact patients' lives, making your role not just a job, but a commitment to better health outcomes. If you are passionate about data engineering and eager to make a difference, we encourage you to join our mission!

Frequently Asked Questions (FAQs) for Bioinformatics Data Engineer Role at Revolution Medicines
What are the main responsibilities of a Bioinformatics Data Engineer at Revolution Medicines?

The Bioinformatics Data Engineer at Revolution Medicines is responsible for transferring, organizing, curating, and disseminating biomarker data from clinical trial samples. This role involves acting as the main liaison between internal scientists and external diagnostic providers, developing scripts for data cleaning and uploading, carrying out data modeling, and collaborating with various departments to ensure controlled dissemination of data.

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What qualifications are required for the Bioinformatics Data Engineer position at Revolution Medicines?

Candidates for the Bioinformatics Data Engineer position at Revolution Medicines should possess a Master's or Bachelor's degree with at least 3 years of experience in fields related to biology or computer science. Proficiency in Python and R, knowledge of SQL, and familiarity with bioinformatics data are essential.

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What tools and technologies does a Bioinformatics Data Engineer use at Revolution Medicines?

In their role, a Bioinformatics Data Engineer at Revolution Medicines utilizes various tools and technologies including Linux clusters, cloud computing solutions, SQL databases, Python and R for data manipulation, and data visualization packages like R Shiny or PowerBI.

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How does the Bioinformatics Data Engineer role contribute to drug development at Revolution Medicines?

The Bioinformatics Data Engineer plays a crucial role in drug development by ensuring high-quality biomarker data management, which is essential for making informed decisions in clinical trials. Their work supports cross-functional teams and optimizes the data pipelines necessary for advancing targeted therapies.

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What is the expected salary range for a Bioinformatics Data Engineer at Revolution Medicines?

The expected salary range for a Bioinformatics Data Engineer at Revolution Medicines is between $120,000 and $145,000, depending on skills, experience, and other factors such as individual performance and market dynamics.

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Common Interview Questions for Bioinformatics Data Engineer
What experience do you have with data curation in a bioinformatics context?

Highlight your hands-on experience with data curation, discussing specific projects where you organized and quality-checked biomarker data. Emphasize how you ensured data integrity and collaborates with scientists, showcasing your attention to detail and problem-solving skills.

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Can you describe a project where you collaborated with scientists and external providers?

Share a brief story about a project where you served as the main point of contact. Illustrate how this experience taught you about effective communication and problem-solving with diverse teams, while also emphasizing your contribution in maintaining clarity and organization.

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What programming languages are you proficient in, and how have you used them in your previous roles?

Mention your proficiency in programming languages such as Python and R. Describe specific tasks you completed using these languages, such as data manipulation or developing visualization dashboards, showing how these skills align with the job's requirements.

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How do you ensure data quality and accuracy when managing large datasets?

Discuss your systematic approach to data quality assurance, such as implementing checks and validations at various stages and utilizing scripts for data cleaning. Provide examples of your strategy for regularly auditing datasets and the impact it had on project outcomes.

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What role does cloud computing play in your data management processes?

Explain your knowledge of cloud computing and how you have used it for data storage and transfer. Highlight benefits such as scalability, data accessibility, and efficient collaboration with teams, and how these features enhance your contributions to projects.

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Can you give an example of how you’ve used data visualization to communicate findings?

Share specific examples where you created data visualizations to help convey complex information. Discuss the tools you used, the audience you presented to, and how this made the data more accessible and informative, leading to better decision-making.

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Describe your experience with SQL and database management.

Talk about your background in designing and querying databases using SQL. Provide concrete examples of how you've used SQL in past roles to support data retrieval and management, including how this has improved data accessibility for your teams.

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What do you know about biomarker data analysis?

Discuss your understanding of biomarker data analysis, mentioning tools and techniques you have experience with. Describe specific analyses you conducted in past projects and the insights gained that advanced the objectives of those projects.

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How do you stay updated with the latest trends in bioinformatics?

Share methods you use to keep up with the latest advancements in bioinformatics, such as attending conferences, subscribing to journals, participating in webinars, and engaging with online communities. Highlight how staying informed helps you innovate in your work.

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What motivates you to work in the field of bioinformatics?

Convey your passion for bioinformatics and its potential to impact cancer treatments positively. Discuss how your unique skills align with Revolution Medicines' mission and how they inspire you to contribute your best work towards the fight against cancer.

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Full-time, on-site
DATE POSTED
December 16, 2024

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