Research Associate Contractor, Hit Validation, Program Enablement and Mechanism of Action Deconvolution

As a Research Associate Contractor at Remix Therapeutics, your primary responsibilities will include designing and conducting cell-based experiments, developing and validating in vitro assays for small molecule hit discovery, analyzing screening hits, and communicating findings within the multidisciplinary team. You'll be critical in executing assays that monitor RNA processing events, contributing to our innovative drug discovery platform.

Candidates for the Research Associate Contractor position at Remix Therapeutics should possess a B.S. or M.S. in cellular and molecular biology or a related discipline. Additionally, 2-3 years of experience in early-stage small molecule drug discovery, proficiency with cell culture techniques, and a solid understanding of gene expression readouts are essential qualifications.

Essential skills for a Research Associate Contractor at Remix Therapeutics include strong experimental design and execution capabilities, proficiency in cell culture management, and expertise with techniques such as qPCR and multiplex assays. You should also have excellent organizational skills, critical thinking abilities, and a collaborative mindset to work effectively within our cross-functional teams.

The pay for the Research Associate Contractor position at Remix Therapeutics ranges between $40 to $45 per hour, depending on your experience. We value our employees and believe in offering competitive compensation to recognize their contributions to our mission.

Yes, Remix Therapeutics is committed to equal employment opportunity and will make reasonable accommodations for qualified individuals with known disabilities in accordance with applicable law throughout the application and hiring processes for the Research Associate Contractor role.

In your response, detail specific cell culture techniques you've mastered, such as maintaining adherent and suspension mammalian cell lines, and provide examples of how you've measured cell viability and gene expression. Highlight instances where your skills contributed to successful experiments, keeping the focus on their relevance to the role at Remix.

It's important to demonstrate your knowledge of various data analysis methods such as qPCR, immunoblots, and NGS workflows. Discuss specific software tools you are comfortable using for data visualization, and provide examples where you had to interpret complex data results to draw meaningful conclusions for drug discovery.

Highlight your organizational skills by discussing your strategies for prioritization, such as using project management tools or schedules. Include examples from your previous roles where you successfully navigated time constraints and resource limitations while ensuring quality results were achieved.

Prepare a specific example that illustrates your ability to work in a multidisciplinary team environment. Describe your role within the team, the project goals, and how your contributions helped achieve those goals. Emphasize teamwork, communication, and outcomes.

Discuss your understanding of RNA biology, particularly how splicing, stability, and turnover impact drug development efforts. Providing insights into your past work involving these elements will showcase your knowledge and its relevance to the role at Remix.

Share relevant experiences you have with pharmacological treatments, transfection processes, and gene editing technologies such as CRISPR, focusing on specific outcomes or results that arose from these experiments and how they pertain to ongoing drug discovery efforts.

It's crucial to emphasize the importance of detailed record-keeping in the research process. Discuss your approach to maintaining detailed experimental protocols and data, your use of electronic laboratory notebooks, and how attention to detail contributes to both reproducibility and credibility in your work.

Talk about your passion for science and your desire to make a positive impact on patient lives. Share personal anecdotes or experiences that inspired you to pursue a career in biotechnology and how this aligns with Remix Therapeutics' mission.

Detail your thought process for experimental design, including hypothesis formulation, selecting appropriate methodologies, and considering controls. Mention any frameworks or guidelines you follow and how you adapt your approach based on the project.

Describe a specific instance where you faced a challenge during your research and explain how you addressed it. Highlight your problem-solving skills, resilience, and ability to learn from setbacks, assuring the interviewer you can navigate obstacles constructively.