Director, Clinical Operations

As the Director, Clinical Operations at Tango Therapeutics, you'll oversee clinical trial management from start to finish. This includes developing timelines, managing relationships with CROs and clinical sites, ensuring deliverables meet budget expectations, and mentoring team members for professional growth. You'll also be responsible for addressing any challenges or risks that arise during trials, maintaining operational excellence, and fostering collaboration across various functional areas.

To qualify for the Director, Clinical Operations position at Tango Therapeutics, candidates should possess a BA/BS in nursing, biology, biochemistry, or a related field, with at least 12 years of experience in clinical research operations. Oncology experience is crucial, with a preference for 5+ years, along with a solid foundation in biotechnology and early-phase experience, including IND submissions. Strong project management skills and familiarity with GCP/ICH regulations are necessary for success in this role.

The Director, Clinical Operations plays a vital role in fulfilling Tango Therapeutics’ mission by ensuring that clinical trials are executed efficiently and effectively. By managing the intricate details of trial operations, you help bring innovative cancer therapies from concept to reality, directly impacting patient outcomes and advancing precision medicine. Your leadership and expertise in navigating clinical research help drive the company forward in its commitment to revolutionizing cancer treatment.

Success as a Director, Clinical Operations at Tango Therapeutics hinges on several key skills: excellent project management capabilities, strong vendor management experience, and an eye for detail are paramount. You must also possess outstanding written and verbal communication skills to effectively collaborate with internal teams and external partners. Additionally, analytical problem-solving skills are crucial for addressing the complex challenges that arise during clinical trials.

At Tango Therapeutics, you can expect a fast-paced, collaborative working environment that values innovation and flexibility. As a Director, Clinical Operations, you will engage with diverse teams and external partners, ensuring streamlined operations in a role that requires both strategic planning and execution. The culture promotes continuous learning and mentorship, allowing you to grow alongside your colleagues while making meaningful contributions to the field of oncology.

In your response, highlight specific oncology trials you've managed, discussing your role in the planning, execution, and monitoring stages. Emphasize how you collaborated with CROs, managed timelines, and overcame challenges to deliver successful outcomes, showcasing your expertise and passion for oncology.

Discuss your approach to establishing open lines of communication, such as regular updates and meetings. Highlight tools you utilize, like project management software, and stress the importance of fostering a collaborative team culture to keep everyone aligned and informed.

Describe your organizational techniques, such as developing timelines and to-do lists, and using software to track progress. Explain how you assess urgency and importance while maintaining flexibility to adapt to any changes or unforeseen circumstances.

Share your experience in identifying, negotiating with, and managing vendors for clinical trials. Provide examples of how you've established strong partnerships and resolved issues to ensure that deliverables meet the project’s objectives while maintaining quality.

When answering, highlight your commitment to fostering growth and development by offering guidance, support, and constructive feedback. Share previous successful mentorship experiences and how you've helped junior staff enhance their skills and confidence in their roles.

Explain your methodology for risk assessment, including identifying potential risks at the start of trials and continuously monitoring throughout the process. Discuss how you involve the team in proactive problem-solving and decision-making to mitigate risks effectively.

You could provide a brief overview of GCP and ICH guidelines and their importance in clinical research. Mention any relevant training or certifications you've completed and how you apply this knowledge to ensure compliance and quality assurance in clinical trials.

Share a specific example where you encountered a challenge, detailing the situation, actions you took to address it, and the outcome. Emphasize your ability to remain calm under pressure and implement effective solutions that supported the trial's progression.

Discuss your practices for maintaining data integrity, such as regular reviews and audits of trial data, training staff on proper data entry protocols, and closely collaborating with statisticians and data managers to resolve discrepancies swiftly.

Clearly outline your expectations, such as opportunities for professional growth, collaboration with a committed team, and meaningful contributions to oncology research. Emphasize your enthusiasm for Tango’s mission and how you hope to be a part of it.