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Senior CADD Scientist

Genesis Therapeutics is assembling a world-class computational chemistry team to revolutionize drug discovery through cutting-edge machine learning and biophysical simulation. We are seeking a Senior CADD Scientist to join our on-site discovery team in San Diego, working directly with scientists  in our state-of-the-art wet lab and with our distributed computational chemistry and CADD science teams across the US.


What You Will Do (Key Responsibilities)
  • Utilize a combination of industry-standard and proprietary AI-powered CADD tools to guide small molecule drug discovery programs across a diverse target portfolio, including novel targets with limited chemical precedents.
  • Use approaches like virtual screening, molecular simulation, and potency and ADMET prediction to support key decision-making in drug discovery efforts.
  • Collaborate closely with medicinal chemists in molecular design and the development of project-specific computational approaches.
  • Act as a cross-team connector, effectively communicating between our computational chemistry and medicinal chemistry teams to ensure seamless information flow and collaborative decision making.
  • Adapt to a fast-paced environment where innovation and quick iteration are encouraged.


What you’ll bring
  • PhD in Computational Chemistry, Structural Biology, or a related field. This particular role may also be suitable for PhD-level scientists with degrees in organic or medicinal chemistry with extensive experience in the lab, who have transitioned into industry roles in CADD.
  • Deep understanding of structure-based drug design and protein-ligand interactions.
  • Proficiency with industry-standard CADD tools such as MOE, PyMOL, and Schrodinger Suite.
  • Minimum of 2+ years of industry experience as a CADD scientist in pharma or biotech, with hands-on experience in active drug discovery programs.


What we offer
  • Competitive Pay
  • Health Care Plans (including Medical, Dental, and Vision, fully covered for the employees)
  • Stock Option Eligibility
  • 401(k) Plan
  • Open PTO Policy
  • Paid Company Holidays
  • Free lunch and snacks at our offices


Genesis Therapeutics is unifying AI and biotech to discover novel and breakthrough treatments for patients with severe and devastating conditions. Genesis was founded on groundbreaking molecular ML research and since has established itself as the industry leader in AI for small molecule drug discovery. Our team of accomplished biotech leaders and expert drug hunters joins forces with deep learning researchers and software engineers who are pioneering predictive and generative AI technologies for molecules.


Our team has created the industry's most advanced molecular AI platform called GEMS (Genesis Exploration of Molecular Space), to accelerate and optimize small molecule drug discovery and to enable the discovery of novel first-in-class and best-in-class small molecule drugs for challenging and/or undruggable targets. 


The company has leveraged GEMS to build an internal pipeline with multiple programs against high-value targets, including data-poor and canonically undruggable targets where GEMS is uniquely advantaged. In addition, Genesis has signed AI-focused platform collaborations with major pharmaceutical companies, including most recently Incyte Corporation (Feb 2025) and Gilead Sciences (Sept 2024).


We raised a $200M series B in August 2023, and have raised over $300M in funding from top technology and biotech investors, including Andreessen Horowitz, Rock Springs Capital, T. Rowe Price, Fidelity, Radical Ventures, NVentures (NVIDIA's VC arm), BlackRock, and Menlo Ventures. 


Genesis is headquartered in Burlingame, CA, with a fully integrated laboratory in San Diego. We are proud to be an inclusive workplace and an Equal Opportunity Employer.

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Average salary estimate

$135000 / YEARLY (est.)
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$120000K
$150000K

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What You Should Know About Senior CADD Scientist, Genesis Therapeutics

At Genesis Therapeutics, we're on a mission to transform drug discovery with the most advanced AI technologies, and we're in search of a talented Senior CADD Scientist to join our dynamic team in San Diego. In this exciting role, you'll get to work side-by-side with leading scientists in our sophisticated wet lab, pushing boundaries with cutting-edge machine learning and biophysical simulations. Here, you will lead small molecule drug discovery initiatives across a wide array of targets—some of which present unique challenges. Your expertise will be crucial as you utilize state-of-the-art CADD tools, engage in virtual screening, molecular simulation, and make vital predictions regarding potency and ADMET. Collaborating closely with medicinal chemists, you'll help craft tailored computational approaches for our projects. Plus, you’ll act as the vital link between computational and medicinal chemistry teams, fostering communication and collaboration that drives innovation. If you're ready to thrive in a fast-paced environment that encourages quick iteration and creativity, this role is perfect for you! Join us at Genesis Therapeutics and help us harness AI to develop groundbreaking treatments for those in need.

Frequently Asked Questions (FAQs) for Senior CADD Scientist Role at Genesis Therapeutics
What are the key responsibilities of a Senior CADD Scientist at Genesis Therapeutics?

As a Senior CADD Scientist at Genesis Therapeutics, you'll be responsible for guiding small molecule drug discovery programs using advanced AI-powered CADD tools, engaging in virtual screening, molecular simulation, and predicting drug potency and ADMET. You will collaborate closely with medicinal chemists and act as the connector between teams to facilitate seamless communication and innovative decision-making.

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What qualifications are required for the Senior CADD Scientist position at Genesis Therapeutics?

To qualify for the Senior CADD Scientist role at Genesis Therapeutics, candidates should hold a PhD in Computational Chemistry, Structural Biology, or a related field. Alternatively, experienced professionals with a degree in medicinal or organic chemistry and a strong CADD background may also be considered. Candidates must demonstrate proficiency with industry-standard CADD tools and have at least 2 years of hands-on experience in drug discovery.

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How does the Senior CADD Scientist contribute to drug discovery at Genesis Therapeutics?

The Senior CADD Scientist plays a pivotal role at Genesis Therapeutics by employing a variety of computational techniques like virtual screening and molecular simulation to support drug discovery. This position directly influences project outcomes by providing critical data and insights, collaborating effectively with other scientists, and ensuring that innovative approaches are utilized in decision-making processes.

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What kind of technologies does a Senior CADD Scientist work with at Genesis Therapeutics?

At Genesis Therapeutics, a Senior CADD Scientist works with cutting-edge AI-powered CADD tools and software like MOE, PyMOL, and Schrodinger Suite. These technologies enable scientists to conduct detailed analyses and predictive modeling that are essential for addressing complex drug discovery challenges.

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What work environment can a Senior CADD Scientist expect at Genesis Therapeutics?

The work environment for a Senior CADD Scientist at Genesis Therapeutics is collaborative and highly innovative. With access to a state-of-the-art laboratory in San Diego, you'll have the opportunity to work with a multidisciplinary team that values quick iteration and creativity, fostering an open culture that encourages groundbreaking ideas.

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Common Interview Questions for Senior CADD Scientist
Can you explain your experience with virtual screening in drug discovery as a Senior CADD Scientist?

When answering this question, highlight specific projects where you utilized virtual screening techniques. Discuss the software tools used, the methodologies applied, and the impact your work had on decision-making within the project.

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How do you prioritize and manage your projects in a fast-paced biotech environment?

A good way to answer this is to talk about your time management strategies, such as setting clear goals, using project management tools, and maintaining close communication with team members to align priorities. Emphasize the importance of flexibility and adaptability in a dynamic setting.

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What is your approach to collaboration with medicinal chemists?

Highlight your experience in fostering effective communication between computational and medicinal chemistry teams. Discuss how you ensure that insights from CADD inform molecular design and how you value the input from your colleagues to enhance the drug discovery process.

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Describe a challenge you faced in drug design and how you overcame it.

Share a specific example that details the challenge, your thought process in addressing it, and the eventual outcome. This demonstrates both your problem-solving skills and your expertise as a Senior CADD Scientist.

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What role does AI play in your current understanding of CADD?

Discuss the transformative impact of AI on CADD and drug discovery processes. Provide examples of how AI tools significantly enhance predictive accuracy and speed, enabling scientists like yourself to conduct more effective research.

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How familiar are you with structure-based drug design?

Discuss your academic and professional background in structure-based drug design, including specific tools or techniques you have employed. Providing examples of projects you've worked on will add credibility to your experience.

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What attributes do you believe are essential for a Senior CADD Scientist?

Emphasize key attributes such as strong analytical skills, an innovative mindset, a collaborative spirit, and the ability to adapt in a fast-paced environment. Relate these attributes to the expectations at Genesis Therapeutics and how they align with your own professional values.

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How do you stay updated with advancements in computational chemistry?

Mention your methods of staying informed, such as attending conferences, participating in online forums, or reading journals relevant to computational chemistry and drug discovery. Show your eagerness to learn and grow in the field.

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Can you provide an example of a successful drug discovery project you contributed to?

Use this opportunity to delve into a specific project, detailing your contributions, the challenges faced, and the ultimate success achieved. This showcases your practical experience and the impact you can have at Genesis Therapeutics.

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What motivates you to work in drug discovery?

Share your passion for improving patient outcomes through drug discovery. Articulate how your background and experiences have shaped this motivation and how it aligns with the mission of Genesis Therapeutics.

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DATE POSTED
April 3, 2025

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