Scientist, Protein Sciences

As a Scientist in Protein Sciences at Calico Life Sciences, you will be primarily responsible for applying biochemistry techniques, biophysical characterization, and assay development to support research focused on human aging. Your role will involve close collaboration with protein biochemists to deepen the understanding of protein targets and potential therapeutics. You'll be developing assays, interpreting data, and presenting your findings to various teams, contributing actively to exciting research projects.

The ideal candidate for the Scientist, Protein Sciences position at Calico must hold a PhD in Biochemistry or a related discipline. It's essential to have experience developing assays and interpreting biophysical characterization data relevant to protein interactions. In-depth knowledge of biophysical binding assays, including Biacore and ITC, is also crucial. Being detail-oriented, possessing strong communication skills, and having the ability to work independently and collaboratively are equally important for success.

The work environment at Calico Life Sciences for a Scientist in Protein Sciences is highly collaborative and innovative. Employees are encouraged to engage in curiosity-driven discovery in a supportive atmosphere that promotes teamwork. You will work onsite five days a week, where you can share ideas and results with colleagues from various disciplines, contributing to a vibrant research community focused on improving human health.

Calico Life Sciences offers significant career growth opportunities for a Scientist in Protein Sciences, driven by its commitment to research and development. As you gain experience and contribute to important projects, there may be opportunities to take on greater responsibilities, lead initiatives within your team, or explore advancements in other areas of the company. The culture of continuous learning and collaboration provides an excellent foundation for professional development.

When you join Calico Life Sciences as a Scientist, you can expect a competitive base salary ranging from $135,000 to $145,000, along with eligibility for two annual cash bonuses. Beyond salary, employees enjoy a collaborative and innovative work environment, opportunities for professional growth, and a commitment to work-life balance, enhancing overall job satisfaction.

When answering this question, highlight your hands-on experience with various biophysical assays relevant to protein interactions, such as Biacore or ITC. Discuss specific projects where you developed or optimized these assays, the technical challenges you faced, and how you addressed them. Show your ability to analyze and interpret data, emphasizing the impact of your work on the project outcomes.

In responding to this question, outline your systematic approach to assay development, including literature review, experimental design, and optimization processes. Mention any specific techniques you have employed, and reflect on results, iterations, and how you validated your assays for accuracy and reproducibility. This showcases both your technical skills and critical thinking.

When discussing techniques for protein purification, reference methods such as affinity chromatography, ion-exchange chromatography (IEX), and size-exclusion chromatography (SEC). Provide examples of proteins you have purified and describe the challenges you overcame during the purification process, which demonstrates your practical experience and problem-solving abilities.

For this question, emphasize your experience with data analysis software and techniques relevant to biophysical characterization. Mention specific tools you're familiar with and describe your analytical approach, including any statistical methods you employ. Highlight examples where your analysis led to key insights in your projects, showcasing your attention to detail and analytical mindset.

When responding, discuss your experience with specific binding assays and techniques like surface plasmon resonance (SPR) or microscale thermophoresis. Share insights into how you've established binding affinities and kinetics, mentioning any successful projects where this characterization helped advance the research or therapeutic strategies.

Share a specific example of a project that presented significant challenges—whether technical difficulties, time constraints, or resource limitations. Discuss how you approached these challenges, the solutions you implemented, and the lessons learned. This provides insight into your problem-solving skills and resilience.

Express your commitment to continual learning by mentioning specific journals, conferences, and networking groups you participate in to stay informed about advances in protein sciences. Discuss any courses or certifications you've pursued that relate to the latest methodologies or technologies in the field.

Outline your standard operating procedures (SOPs) for maintaining consistency and reliability in experiments. Discuss your practices for documentation, controls, and repeatability, as well as how you address deviations when they occur. This shows your focus on quality and integrity in your work.

When answering, provide an example where you effectively communicated complex scientific information to non-expert stakeholders. Discuss the strategies you utilized to engage your audience and the feedback received. Highlight your ability to tailor your communication style based on your audience, demonstrating your collaboration skills.

When asked this question, share your passion for research related to aging and disease. Discuss how Calico’s mission resonates with your career goals and values, and why you are excited about the innovative environment at Calico Life Sciences. This shows cultural fit and genuine enthusiasm for the role.