Principal Research Scientist I, Cell Line Engineering

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok.

Discovery Biotherapeutics and Genetic Medicine at Abbvie is seeking a highly motivated Principal Scientist with a strong understanding of therapeutic discovery and target-overexpressing (OE) stable cell line development to lead the Cell Line Engineering team at the AbbVie Bioresearch Center (ABC). The ABC site, based in Worcester, MA, offers a unique setting where Biologics drug discovery, development and manufacturing coexist in one location. In this position, the leader will be responsible for construct development, mammalian cell line engineering, characterization and stability testing, single cell cloning, as well as enhancement of platform processes.  Experience with high throughput cell line development, automation and PLM implementation for process optimization are preferred.

Job Responsibilities:

• Executes and guides the development and characterization of construct designs and stable target-OE or KO cell lines empowering all stages of Discovery research.
• Identify and implement advanced technologies strategically to develop stable target-OE cell lines, pools, and clones.
• Provide strategic, operational, and scientific guidance to the cell line engineering team.
• Conduct general laboratory research proficiently and independently, adapting and troubleshooting experimental designs and equipment to meet research requirements.
• Apply creative thinking to solve complex problems and promote new technologies, while effectively communicating mission and ideas to diverse audiences.
• The ideal candidate should be able to manage multiple projects across therapeutic disciplines within a dynamic and fast-paced team setting.

Qualifications:

• BS with 14+ years of experience or MS with 12+ years of experience or PhD +6 years of experience in Biology, Molecular and Cellular Biology, Immunology or related field.
• Broad experience in cell line engineering (OE/KO) across diverse cell types, with a proven track record of contributing to drug candidate development.
• Expertise in molecular biology for plasmid construction and familiarity with different expression vectors and promoter types.
• Demonstrates strong attention to quality and detail in organizational, documentation, and communication to work effectively within a collaborative work environment.

Desirable:

• Experience with advanced automated cell culture systems
• Experience implementing PLM for process improvement
• Experience managing vendor relationships for cell line work

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​

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• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.​

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​

• This job is eligible to participate in our short-term incentive programs. ​

• This job is eligible to participate in our long-term incentive programs​

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Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. 

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion.  It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.

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