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Sr. Research Associate/Scientist

Company Overview

ModeX Therapeutics, an OPKO Health subsidiary, is a clinical-stage biopharmaceutical company developing next-generation multispecific antibodies as novel therapies for cancer and infectious diseases, as well as nanoparticle technologies for the development of next-generation vaccines.  ModeX's modular antibody platforms unite the power of multiple biologic components in a single molecule to create multispecific antibodies with greater versatility and potency to fight complex diseases more effectively than traditional approaches. Our current pipeline includes immuno-oncology candidates against both solid and hematological tumors as well as several of the world's most pressing viral threats. Our founding team includes globally recognized medical innovators with proven track records of delivering breakthroughs for patients. Join our team of groundbreaking scientists and leaders today to change the world tomorrow.

External Description

Position Summary:

 

We are seeking a highly skilled and motivated biochemist to join our Protein Science group. The individual will be part of a multidisciplinary team to design, produce and characterize novel therapeutic antibodies.  This is an exciting opportunity to be part of a cross-functional team and contribute to the development of cutting-edge biotherapeutics in a fast-paced, rapidly growing biotech company with a bold vision.

 

Key Responsibilities:

  • Collaborate closely with colleagues with diverse scientific backgrounds and contribute to our interdisciplinary Biologics Discovery and Drug Development team to drive the design and production of innovative therapeutic molecules, and the optimization of their biochemical/ biophysical properties.
  • Serve as the SME of antibody expression and purification platforms and contribute to ModeX’s multi-targeting strategy through antibody engineering and the optimization of production and screening workflows.
  • Independently develop protein purification processes and carry out multistep purification to generate high-quality antibodies for downstream biochemical/biophysical assays and functional screening.
  • Be responsible for experimental planning, execution, data analysis/interpretation, and communication with cross-functional teams for successful completion of projects.
  • Ensure effective, high-quality, timely and appropriate documentation in electronic laboratory notebooks.

 

Qualifications:

  • MS or Ph.D in protein science, biochemistry, structure biology or other related disciplines.
  • Minimum of 6 years (MS)/ 3 years (Ph.D) of relevant lab experiences
  • Skilled in common mammalian cell culture and recombinant protein expression using both transient and stable expression platforms.
  • Direct experience with various protein purification techniques including affinity, IEX and SEC chromatography and AKTA based purification platforms is required.
  • Familiar with routine biologics characterization and analytics technologies including BLI/SPR, ELISA, HPLC and UPLC.
  • Knowledge in antibody structure and function, and experience in antibody drug discovery and multispecific antibody development are preferred.
  • Excellent written and oral communication, organization, and data analysis skills. Outstanding troubleshooting and problem-solving skills.
  • Highly adaptable to a fast-paced work environment and capable of working both independently and collaboratively within project teams.

 

ModeX Therapeutics is an Equal Opportunity Employer

Average salary estimate

$100000 / YEARLY (est.)
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$80000K
$120000K

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What You Should Know About Sr. Research Associate/Scientist, ModeX Therapeutics Inc

At ModeX Therapeutics in Weston, we are on a mission to revolutionize the way we fight cancer and infectious diseases, and we need a talented Sr. Research Associate/Scientist to join our dynamic Protein Science group. If you thrive in an innovative environment and love to collaborate with diverse scientific minds, this position is perfect for you! Here, you will not only design, produce, and characterize cutting-edge therapeutic antibodies, but you'll also play a vital role in optimizing their biochemical and biophysical properties. You'll work closely with a multidisciplinary team dedicated to driving our multi-targeting strategy and enhancing our antibody expression processes. Your expertise in protein purification techniques, including chromatography and AKTA platforms, will be crucial in generating high-quality antibodies for important assays. This is a fantastic opportunity for individuals with a passion for biotherapeutics and a desire to work on groundbreaking treatments that will help others. With a minimum of six years of lab experience for those with a Master's or three years for Ph.D. holders, we’re looking for someone who is not only skilled but also adaptable to a fast-paced environment. At ModeX, you’ll ensure that high-quality documentation is always maintained, communicate effectively with cross-functional teams, and engage in exciting experimental planning and execution. Join us, and be a part of a team that’s changing the world tomorrow with the groundbreaking science of today!

Frequently Asked Questions (FAQs) for Sr. Research Associate/Scientist Role at ModeX Therapeutics Inc
What are the main responsibilities of a Sr. Research Associate/Scientist at ModeX Therapeutics?

As a Sr. Research Associate/Scientist at ModeX Therapeutics, you will be responsible for collaborating with a multidisciplinary team to design, produce, and characterize innovative therapeutic antibodies. Your role will include developing and optimizing protein purification processes, ensuring high-quality documentation, and engaging in experimental planning and execution. This position is integral to driving our Biologics Discovery and Drug Development efforts.

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What qualifications do I need to apply for the Sr. Research Associate/Scientist position at ModeX Therapeutics?

To qualify for the Sr. Research Associate/Scientist role at ModeX Therapeutics, you should have either a Master’s or Ph.D. in protein science, biochemistry, structural biology, or a related field. Additionally, having a minimum of six years of relevant lab experience (or three years with a Ph.D.) is essential, along with proficiency in mammalian cell culture and recombinant protein expression.

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What techniques should I be familiar with for the Sr. Research Associate/Scientist role at ModeX Therapeutics?

Candidates for the Sr. Research Associate/Scientist position at ModeX Therapeutics should be proficient in various protein purification techniques, such as affinity, ion-exchange (IEX), and size exclusion chromatography (SEC). Familiarity with AKTA-based purification platforms and routine biologics characterization techniques, including BLI/SPR, ELISA, HPLC, and UPLC, is also important.

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What is the work environment like at ModeX Therapeutics for the Sr. Research Associate/Scientist?

The work environment at ModeX Therapeutics is fast-paced and dynamic, emphasizing collaboration among talented scientists with diverse backgrounds. As a Sr. Research Associate/Scientist, you'll have the opportunity to engage in exciting projects, contribute to innovative therapeutic solutions, and work both independently and as part of a team committed to groundbreaking advancements in biotherapeutics.

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What career growth opportunities exist for Sr. Research Associate/Scientists at ModeX Therapeutics?

At ModeX Therapeutics, Sr. Research Associate/Scientists are presented with ample opportunities for career growth. By working on cutting-edge projects and collaborating with experts in the field, you will enhance your skills and contribute to meaningful advancements in biotherapeutics, paving the way for potential leadership positions or specialized roles in research and development.

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Common Interview Questions for Sr. Research Associate/Scientist
Can you explain your experience with protein purification techniques?

In your response, detail your hands-on experience with various purification methods like affinity chromatography, IEX, and SEC. Mention specific projects where you successfully applied these techniques to purify therapeutic antibodies. Highlight any challenges you faced and how you overcame them to enhance your credibility.

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Describe a project where you contributed to antibody engineering.

Here, share a specific project example that illustrates your role in antibody engineering. Discuss the objectives, your contributions to the optimization process, and the outcomes. Emphasize your knowledge in antibody structure and function to show your expertise and relevance to ModeX Therapeutics' goals.

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How do you ensure accurate documentation in your research?

Explain your approach to maintaining high-quality documentation, such as using electronic laboratory notebooks. Provide an example of how your meticulous record-keeping has facilitated collaboration within your team and led to successful project outcomes, showing your attention to detail.

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What strategies do you use for effective data analysis?

Discuss your preferred methods for data analysis, including specific software or tools you utilize. Provide an example where your data analysis aided in making critical decisions during a project, highlighting your analytical thinking and problem-solving abilities.

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How do you maintain effective communication within cross-functional teams?

Describe your communication style and techniques for ensuring clarity when collaborating with colleagues from diverse scientific backgrounds. Mention any tools or strategies you use to facilitate open dialogue and teamwork, and provide an instance where effective communication contributed to project success.

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Can you explain your understanding of antibody drug discovery?

To answer this, demonstrate your knowledge of the antibody drug discovery process—from target identification through lead optimization to clinical development. Highlight your experience with multispecific antibody development and how it aligns with ModeX Therapeutics' mission.

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How do you handle challenges in a fast-paced work environment?

Share specific techniques you use to maintain productivity and flexibility in high-pressure situations, such as prioritizing tasks, seeking feedback, and adapting to changes. Provide a real-life example of how you successfully managed a challenging scenario.

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What motivates you to pursue a career in biotherapeutics?

Articulate your passion for biotherapeutics and the impact it has on patient outcomes. Share personal experiences or inspirations that led you to this field and how they motivate you to contribute to the advancements made at ModeX Therapeutics.

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Describe your experience with mammalian cell culture.

Detail your experience with mammalian cell culture techniques, including specific cell lines you have worked with and any relevant protocols you performed. Highlight any challenges you faced and how you addressed them to ensure successful outcomes.

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How do you approach collaboration in research?

Explain your philosophy on teamwork and describe how you foster collaborative relationships with colleagues. Provide examples of how your collaborations have led to successful project results, emphasizing your adaptability in a multidisciplinary setting.

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Full-time, on-site
DATE POSTED
April 12, 2025

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