Temporary Senior RA/Scientist, Proteomics

As a Temporary Senior Research Associate or Scientist in Proteomics at Plexium, you will design and perform proteomics experiments to analyze protein expressions, modifications, and interactions. Your daily tasks will also involve maintaining and calibrating mass spectrometry systems and conducting QC checks to ensure the instruments are performing optimally. Additionally, you will prepare reports and collaborate with different teams to advance our drug discovery programs.

For the Temporary Senior Research Associate/Scientist, Proteomics position at Plexium, candidates should possess a Ph.D. in Biochemistry, Analytical Chemistry, Molecular Biology, or a related field. Alternatively, a Master's or Bachelor's degree along with relevant experience is acceptable. Essential qualifications include a minimum of three years of hands-on experience with mass spectrometry-based proteomics, particularly with instruments like the Bruker timsTOF Pro and timsTOF HT.

Successful candidates for the Temporary Senior Research Associate/Scientist position in Proteomics at Plexium must have proven technical skills in mass spectrometry-based proteomics, including sample preparation and data analysis. You should also be proficient in using bioinformatics tools such as Maxquant, DIA-NN, and have familiarity with coding languages like R or Python. Experience with high throughput sample preparation platforms is preferred.

The US hourly range for the Temporary Senior Research Associate/Scientist in Proteomics at Plexium is between $41.11 and $56.25. This range takes into account factors such as the role, location, job-related skills, and the level of education and experience of the candidate. The salary is competitive and will be discussed further by our Human Resources Team during the hiring process.

The Temporary Senior Research Associate/Scientist position in Proteomics at Plexium is designed to be a full-time, temporary role lasting approximately six months. This opportunity allows you to dive deep into innovative drug discovery processes while contributing to meaningful work in targeted protein degradation.

Highlight your hands-on experience with mass spectrometry instruments. Discuss specific techniques you've used, such as LC-MS/MS, and provide examples of experiments you have designed or contributed to. Emphasize any innovative methods you've developed and the outcomes of those studies.

Detail your experience with various sample preparation workflows, such as protein digestion and affinity purification. Discuss how you ensure reproducibility and efficiency in your process and any optimizations you’ve made that improved data quality or throughput.

Discuss your routine maintenance practices, including calibration schedules and QC checks. Provide examples of issues you've encountered and how you effectively diagnosed and resolved them, demonstrating your technical expertise.

Mention relevant software you’ve used, such as MaxQuant, DIA-NN, or Skyline. Discuss how you've utilized these tools for data analysis, what type of analyses you conducted, and the significance of the results in your research.

Share a specific example of a challenge relating to proteomics or mass spectrometry research. Explain the steps you took to analyze the problem, your thought process in finding a solution, and the resulting impact on your work.

Explain your approach to working collaboratively with other teams. Discuss the importance of clear communication, sharing results, and being receptive to feedback. Provide examples of successful collaborations from previous roles.

Discuss the significance of proteomics in identifying potential drug targets and understanding protein interactions within biological systems. Highlight how proteomic studies can provide insights into disease mechanisms and lead to novel drug candidates.

Provide examples of high-pressure scenarios you’ve navigated in the lab. Discuss strategies you employed to keep focused and ensure quality results, such as effective time management and prioritizing tasks.

Explain your best practices for documentation, including maintaining laboratory notebooks, software use for data management, and ensuring all records are clear and traceable. Emphasize the importance of accuracy and compliance in research.

Reflect your enthusiasm for Plexium’s mission in TPD and how your experiences align with their innovative approach to drug discovery. Discuss your passion for science and how this position offers you the chance to leverage your skills while contributing to meaningful research.