Senior Scientist/Principal Scientist, Biotherapeutic Engineering

As a Senior Scientist/Principal Scientist in Biotherapeutic Engineering at Xilio Therapeutics, your responsibilities will encompass the design and generation of complex biologics and multi-specific formats for preclinical therapeutic validation. You will analyze protein structures and perform biochemical and biophysical characterization of engineered proteins, while also supporting antibody discovery efforts. Your role will also involve leading cross-functional teams, defining project strategies, and ensuring that research objectives are met on time.

To qualify for the Senior Scientist/Principal Scientist position in Biotherapeutic Engineering at Xilio Therapeutics, candidates should possess a BS/MS or PhD in Biochemistry, Structural Biology, or a related field, along with relevant industry experience ranging from 3 to 15 years depending on the education level. Strong analytical skills in computational protein and DNA sequence analysis, expertise in biotherapeutics design, and experience with biophysical characterization techniques like SPR are essential.

While not strictly necessary, prior experience with CRO project management is highly preferred for candidates applying for the Senior Scientist/Principal Scientist position at Xilio Therapeutics. Having this experience can significantly enhance your ability to oversee complex projects effectively and ensure successful collaboration with various stakeholders.

Key skills for the Senior Scientist/Principal Scientist role in Biotherapeutic Engineering at Xilio Therapeutics include strong expertise in biotherapeutics design, excellent analytical and problem-solving skills, and proficiency in structural biology. Furthermore, effective leadership and communication skills are crucial, as you will lead cross-functional teams and collaborate closely with diverse stakeholders.

At Xilio Therapeutics, a Senior Scientist/Principal Scientist can expect a fast-paced and collaborative work environment that encourages innovation and scientific exploration. We prioritize equal opportunity and inclusion, offering continuous professional development, performance reviews, and opportunities to engage in job-related trainings, all aimed at fostering employee satisfaction and growth.

When answering this question, highlight specific projects where you designed and engineered biologics, discussing techniques you used, such as structural biology or molecular modeling. This demonstrates your hands-on experience and understanding of the complexities involved in biotherapeutics.

Use this question to provide examples of previous projects where you collaborated with cross-functional teams. Discuss how you communicated effectively and navigated different perspectives to achieve common project goals, showcasing your leadership skills.

Choose a specific challenge that showcases your problem-solving skills. Explain the context, your thought process, and the steps you took to overcome the challenge. This will illustrate your resilience and analytical skills.

Discuss specific analytical tools and methodologies you've used, such as in silico modeling or biochemical assays. Emphasizing your familiarity with software like CCG-MOE or Schrodinger-Maestro highlights your technical skills relevant to the role.

Explain your organizational skills by describing a system or strategy you employ to manage tasks effectively. Discuss how you balance urgency and importance, ensuring that project timelines are met while maintaining quality.

Share specific methods you've used for protein characterization, such as surface plasmon resonance (SPR) or circular dichroism. This demonstrates your technical expertise and familiarity with industry-standard techniques.

Express your passion for making an impact in healthcare, particularly in oncology. Sharing personal anecdotes or research experiences can convey genuine motivation and commitment to the role.

Discuss your specific involvement in antibody discovery, including techniques like yeast or phage display. Highlight successful outcomes of your efforts to demonstrate your relevant expertise in this area.

Explain your understanding of regulatory frameworks and how you've implemented specific protocols in past research projects, emphasizing the importance of maintaining compliance during the development process.

Use this opportunity to express your admiration for Xilio’s mission of improving cancer treatments. Mention elements like their innovative approach to immuno-oncology, as well as your alignment with the company's values and commitment to patient outcomes.