Principal CADD Scientist

As a Principal CADD Scientist at Genesis Therapeutics, you'll engage in a variety of responsibilities essential for advancing drug discovery. You will utilize AI-powered CADD tools for small molecule drug discovery, support decision-making through virtual screening and molecular simulation, and collaborate closely with medicinal chemists on molecular design. Additionally, effective communication across teams will play a key role in ensuring collaborative success.

To excel as a Principal CADD Scientist at Genesis Therapeutics, candidates should possess a PhD in Computational Chemistry, Structural Biology, or a related field. Alternatively, PhD-level scientists with degrees in organic or medicinal chemistry, along with extensive lab experience in CADD, may also qualify. Furthermore, a deep understanding of structure-based drug design and a minimum of 5 years of industry experience in drug discovery are essential.

Success in the Principal CADD Scientist role at Genesis Therapeutics requires proficiency in industry-standard CADD tools such as MOE, PyMOL, and Schrodinger Suite. Additionally, a strong grasp of protein-ligand interactions and structure-based drug design is crucial. The ability to adapt to a fast-paced environment and facilitate effective communication between computational and medicinal chemistry teams will greatly enhance collaboration and innovation.

Genesis Therapeutics offers various career opportunities for CADD professionals, especially within their world-class computational chemistry team. As a Principal CADD Scientist, you'll contribute significantly to cutting-edge drug discovery efforts. Candidates with varying levels of experience in CADD or related fields may find fulfilling roles that cater to their skill sets, particularly in therapeutic advancements and AI integration.

Employees joining Genesis Therapeutics as a Principal CADD Scientist can expect a competitive pay structure along with comprehensive health care plans that fully cover medical, dental, and vision expenses. Additional perks include stock option eligibility, a 401(k) plan, an open PTO policy, paid company holidays, and free lunch and snacks at the office, fostering a supportive and inclusive workplace environment.

In your response, highlight your experience with AI tools and how you've applied them in CADD for drug discovery. Mention specific software you've used, describe successful projects, and illustrate how AI has enhanced decision-making in your past roles.

When addressing this question, focus on a specific project where virtual screening played a key role. Discuss the objectives, tools used, the insights gained, and the impact of your findings on the overall drug discovery process.

For this question, illustrate your interpersonal skills by sharing examples of how you've facilitated communication between different scientific teams. Emphasize how establishing cross-functional relationships contributed to project success.

Select a relevant challenge from your experience and explain the context and your approach to resolving it. Focus on your problem-solving skills, adaptability, and the outcome to showcase your competencies effectively.

Give a comprehensive overview of your experience with structure-based drug design, including specific applications, successful outcomes, and insights gained from previous projects. Highlight tools and methodologies that supported your strategies.

Discuss your commitment to continuous learning. Mention strategies such as attending conferences, reading relevant journals, and networking with industry professionals to stay abreast of trends, technology advancements, and best practices.

In your response, discuss the factors that influence your choice of CADD tools, such as project requirements, quality of data, level of user support, and compatibility with existing systems. Provide examples from your past experiences.

Share specific instances of when you've utilized molecular simulation in your projects. Describe the methodologies used, challenges addressed, and how the outcomes influenced the direction of drug discovery efforts.

Highlight the importance of collaboration in drug discovery and detail your approach to fostering a collaborative environment. Cite examples where teamwork has led to innovative solutions and improved project outcomes.

Articulate your aspirations within the CADD domain, including your desire for professional growth. Discuss how you envision contributing to the field while aligning with the mission and vision of companies like Genesis Therapeutics.