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Senior Research Scientist (PhD)

is one of the nation's top-ranked medical schools. For 175 years, NYU Grossman School of Medicine has trained thousands of physicians and scientists who have helped to shape the course of medical history and enrich the lives of countless people. An integral part of NYU Langone Health , the Grossman School of Medicine at its core is committed to improving the human condition through medical education, scientific research, and direct patient care. At NYU Langone Health, equity, diversity, and inclusion are fundamental values. We strive to be a place where our exceptionally talented faculty, staff, and students of all identities can thrive. We embrace diversity, inclusion, and individual skills, ideas, and knowledge. For more information, go to med.nyu.edu , and interact with us on LinkedIn , Glassdoor , Indeed , Facebook , Twitter and Instagram .

Position Summary:
We have an exciting opportunity to join our team as a Senior Research Scientist (PhD).

The Brandes Lab at NYU School of Medicine is seeking a Senior Research Scientist to help drive the labs research agenda in applying advanced AI models in genomics. Our lab has been at the forefront of developing and using innovative AI models, especially protein language models, to predict protein function and the impact of genetic mutations. Compensation is based candidate's experience and qualifications.
For more information about our lab, visit brandeslab.org

Job Responsibilities:

Conduct cutting-edge genetic research using genomic large language models (LLMs) to analyze biological sequences (DNA, RNA and proteins) and genetic mutations. Analyze large-scale genetic datasets, including those from biobanks and other genetic cohorts. Analyze high-throughput experimental data, including from single-cell sequencing. Collaborate with lab members and external collaborators to achieve research objectives. Contribute to the preparation of research publications and grant proposals.

Potential Projects:

Incorporate variant effect prediction in statistical genetics to implicate rare variants and establish causality. Utilize genomic LLMs to enhance genome-wide association studies (GWAS) and polygenic risk scores (PRS), allowing these studies to focus on variants more likely to have an impact.
Identify specific genetic effects and optimize genomic sequences. Apply AI models to differentiate between various mutation effects, including loss-of-function, gain-of-function and dominant-negative effects. Integrate data from deep mutational scans and single-cell RNA sequencing to identify mutation combinations that optimize genetic backgrounds for therapeutic purposes.
Make AI suitable for the non-coding genome. Generalize our approaches, currently focused on protein sequences, towards LLMs that predict the effects of non-coding variants and their roles in diseases.

Please apply with your CV and a brief outline (up to 2 paragraphs) of your relevant qualifications and interest in the position.

Minimum Qualifications:
To qualify you must have a Expertise in Computational biology
Background in machine learning
A collaborative mindset with excellent communication skills.

Preferred Qualifications:
Expertise in computational biology, with an emphasis on genomic and genetic data analysis. Experience working with large-scale genetic/genomic datasets.
Proficiency in Python and Linux. Background in machine learning. Proficiency in modern AI algorithms, including deep learning, transformers and LLMs.
Experience with deep-learning models in Python, preferably using PyTorch. Experience with single-cell data. A collaborative mindset with excellent communication skills.

Qualified candidates must be able to effectively communicate with all levels of the organization.

NYU Grossman School of Medicine provides its staff with far more than just a place to work. Rather, we are an institution you can be proud of, an institution where you'll feel good about devoting your time and your talents.

NYU Grossman School of Medicine is an equal opportunity and affirmative action employer committed to diversity and inclusion in all aspects of recruiting and employment. All qualified individuals are encouraged to apply and will receive consideration without regard to race, color, gender, gender identity or expression, sex, sexual orientation, transgender status, gender dysphoria, national origin, age, religion, disability, military and veteran status, marital or parental status, citizenship status, genetic information or any other factor which cannot lawfully be used as a basis for an employment decision. We require applications to be completed online.
If you wish to view NYU Grossman School of Medicine's EEO policies, please click here . Please click here to view the Federal "EEO is the law" poster or visit for more information.

NYU Langone Health provides a salary range to comply with the New York state Law on Salary Transparency in Job Advertisements. The salary range for the role is $85,000.00-$120,000.00 Annually. Actual salaries depend on a variety of factors, including experience, specialty, education, and hospital need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.

To view the Pay Transparency Notice, please click here

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What You Should Know About Senior Research Scientist (PhD), NYU Langone Health

Join the dynamic team at NYU Grossman School of Medicine as a Senior Research Scientist (PhD) and make a significant impact in the field of genomics! In this exhilarating role, you'll dive deep into cutting-edge genetic research using advanced AI models to analyze biological sequences, including DNA, RNA, and proteins. The Brandes Lab is looking for a passionate and skilled individual to lead research initiatives that leverage innovative AI techniques to explore the impact of genetic mutations. You'll have the opportunity to analyze large-scale genetic datasets and collaborate with a talented group of lab members and external partners to drive forward our research agenda. Imagine being at the forefront of research that could change lives as you contribute to scientific publications and grant proposals! Working at NYU Langone Health means you’ll be part of a diverse community dedicated to equity and inclusion. Your skills in computational biology and machine learning will be invaluable, particularly your experience with genomic data analysis and programming in Python. With a commitment to fostering an enriching work environment, NYU Grossman School of Medicine offers you more than just a job; it’s a chance to be part of a mission that truly matters. Dive into exhilarating projects like predicting the effects of genetic variants and optimizing genetic backgrounds for therapeutic purposes. If you're excited to take on this challenge and contribute to our understanding of genetics, we want to hear from you! Apply now with your CV and a brief outline of your qualifications to embark on this rewarding journey.

Frequently Asked Questions (FAQs) for Senior Research Scientist (PhD) Role at NYU Langone Health
What are the main responsibilities of a Senior Research Scientist at NYU Grossman School of Medicine?

As a Senior Research Scientist (PhD) at NYU Grossman School of Medicine, you'll conduct cutting-edge research utilizing genomic large language models (LLMs) to analyze biological sequences and genetic mutations. Key responsibilities include analyzing large-scale genetic datasets, collaborating with team members, and contributing to research publications and grant proposals, all aimed at driving innovative research in the field.

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What qualifications are required for the Senior Research Scientist position at NYU Grossman School of Medicine?

To qualify for the Senior Research Scientist (PhD) role at NYU Grossman School of Medicine, candidates must possess expertise in computational biology, particularly in genomic and genetic data analysis, along with a background in machine learning. Collaborative skills and excellent communication abilities are essential. Preferred qualifications include experience with large-scale genetic datasets and proficiency in Python, Linux, and deep learning algorithms.

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What kind of projects will a Senior Research Scientist work on at NYU Grossman School of Medicine?

A Senior Research Scientist at NYU Grossman School of Medicine will work on various fascinating projects, including incorporating variant effect prediction in statistical genetics, enhancing genome-wide association studies with genomic LLMs, and applying AI models to identify genetic effects. This role will also involve optimizing genomic sequences to maximize therapeutic outcomes for specific genetic backgrounds.

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How does NYU Grossman School of Medicine support diversity and inclusion within the research community?

At NYU Grossman School of Medicine, equity, diversity, and inclusion are foundational values. They are committed to creating an environment where exceptionally talented individuals from diverse backgrounds can thrive. The institution strives to support all identities, ensuring that a collaborative mindset and a culture of inclusivity are prioritized in the workplace.

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What is the salary range for the Senior Research Scientist position at NYU Grossman School of Medicine?

The salary range for the Senior Research Scientist (PhD) position at NYU Grossman School of Medicine is $85,000.00 to $120,000.00 annually. This range depends on various factors, including the candidate's experience, specialty, education, and hospital needs, making it a competitive offering in the field.

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Common Interview Questions for Senior Research Scientist (PhD)
Can you describe your experience with genomic data analysis as a Senior Research Scientist?

When answering this question, focus on specific projects where you've successfully analyzed genomic data. Highlight the tools and methods used, such as large language models or machine learning techniques, and explain your role in extracting meaningful insights from complex datasets.

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What advanced AI models are you familiar with, and how have you applied them in your research?

Discuss your experience with various AI models, particularly in the context of genomics, such as deep learning or transformers. Provide examples of how you've implemented these models to achieve research objectives, specifying any relevant results or findings.

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How do you approach collaboration with team members on research projects?

Describe your collaborative approach by emphasizing communication, respect for diverse opinions, and your commitment to achieving common goals. Share examples of successful collaborations and how you navigated challenges to enhance teamwork.

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What are some specific methods you've used to analyze high-throughput experimental data?

Detail your experience with high-throughput experimental data analysis methods such as single-cell RNA sequencing. Explain your familiarity with relevant tools, any software you’ve used, and the outcomes of your analyses to demonstrate your expertise.

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How do you ensure your research aligns with current advancements in AI and genomics?

Talk about your strategies for staying updated on current advancements, such as attending conferences, reading scientific literature, or participating in professional networks. Highlight how you incorporate new findings into your current research to maintain relevance in a rapidly evolving field.

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Describe how you handle challenges in data interpretation as a Senior Research Scientist.

Share an example of a specific challenge you faced in data interpretation, discussing how you approached problem-solving and what resources or methodologies you utilized to overcome the obstacle while maintaining research integrity.

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What motivates you to conduct research in genomics, and how do you communicate your passion in the field?

Discuss your driving motivations for pursuing research in genomics, such as a desire to improve human health or curiosity about genetic mechanisms. Share how you express this passion through your work, speaking engagements, or mentoring.

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How do you prioritize multiple projects and deadlines within a fast-paced research environment?

Explain your time management techniques, such as setting milestones, using project management tools, and maintaining open communication with team members. Provide an example of how you successfully balanced multiple projects without sacrificing quality.

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Can you give an example of a successful research project you led and its impact?

Describe a successful project by outlining the objectives, methodology, and results. Emphasize your role in leading the project and the positive impact it had on your team or the broader research community to illustrate your leadership abilities.

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What role does mentorship play in your research experience, and how do you foster growth in others?

Discuss your philosophy on mentorship and how it has influenced your research environment. Provide examples of how you cultivate growth in junior researchers or students through guidance, sharing knowledge, and creating opportunities for learning.

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DATE POSTED
April 11, 2025

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