Spear Bio, founded in 2021, is a well-funded and rapidly growing start-up headquartered in Woburn, Massachusetts.  Our proprietary technology, Successive Proximity Extension Amplification Reaction (SPEAR), is a novel wash-free immunoassay platform, offering unprecedented sensitivity. We are dedicated to revolutionizing early disease diagnosis and monitoring by providing scalable, ultrasensitive solutions that deliver unparalleled accuracy in measuring low-abundant biomarkers, enabling clinicians and researchers to improve patient outcomes and advance global health.

Scientist/Senior Scientist, Assay Development:

The Scientist/Senior Scientist will play a pivitol role in advancing Spear Bio’s assay development activities for our new range of ultrasensitive immunoassays. The role will have cross-functional responsibilities reporting to the Head of Assay Development, but also interfacing with Platform and Product Development teams. This individual should have a strong track record in immunoassay development for research and clinical applications.

Responsibilities:

• Develop a portfolio of assays and be involved in qualifying and/or validating assays for research and clinical use.

• Design and develop ELISA based assays for ultrasensitive detection of analytes including antibody selection, conjugation of reagents and chemistries, sample preparation and handling, data analysis methodologies.

• Design and perform experiments to demonstrate feasibility, and characterize performance and robustness (dynamic range, limit of detection, spike and recovery, precision, accuracy, and assay linearity) of ELISA based assays.

• Contribute to scientific literature and conferences, internal reports, documents and communications including the writing and/or creation of abstracts, peer-reviewed journal articles, poster presentations, and marketing materials.

• Maintain familiarity with current technology related information and/or literature and conducts project related information searches and may be involved in extensive literature searches. 

• Oversee/mentor junior level staff to guide them on projects

Qualifications:

• Degree in with proven hands-on experience. BS/MS with 6-8+years of relevant experience, or Ph.D. with 2+ years of relevant experience in immunoassay development experience in an industrial setting (e.g., IVD, clinical trials, contract research, or pharmaceutical/biotechnology).

• Deep technical experience in immunoassay development including but not limited to: protein chemistry, antibody screening, antibody conjugation, assay diluent formulation, multiplexing, preanalytical sample processing, scale-up, assay optimization and troubleshooting, Real-Time PCR, immunoassays (immunoblotting and ELISAs) and gel-based assays (SDS-PAGE and CE-SDS), multivariate data analysis; analytical validation; clinical validation.

• Subject matter expertise in the field of protein biomarkers for neurodegeneration or immuno- oncology 

• Advanced understanding of ligand binding assays and diverse analytical formats and platforms including colorimetric/electrochemiluminescence/luminescence/fluorometry-based assays and experience with typical analytical systems, (e.g. MSD, Molecular Devices, Luminex, Ella, Quanterix, Octet, Biacore).

• Strong analytical and problem-solving skills, with demonstrated knowledge of statistical methodologies including DoE experience working within a cGMP/ GLP, and ISO regulated quality system.

General Qualifications:

• Must be able to work independently and have a strong understanding of the theory and biology behind the application and products.

• Strong presentation and interpersonal skills with the ability to establish collaborative working relationships and become a key contributor within the assay development, platform, and product teams.

• Excellent project management skills with an ability to manage and organize work around multiple and changing priorities.

• Work 100% on site in Woburn, MA .

We offer competitive compensation, with meaningful stock ownership, strong benefits, and a great work environment. This is an opportunity to enter an innovative, high-growth startup at an early stage. We are focused on identifying candidates who have demonstrated leadership and excellence throughout their careers and are excited by the prospect of building an industry-leading company.

Spear Bio Inc. provides equal opportunity in employment to all persons. No person shall be denied equal access because of race, creed, color, religion, national origin, sex, sexual orientation, gender identity, age, or physical/mental disability.

Spear Bio does not accept blind resume submissions from external recruiting agencies. Any unsolicited resumes or candidate information submitted without prior written agreement will be deemed the property of Spear Bio, and no placement fees will be paid.