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Senior Scientist, Translational - Onsite Contract Position - 3days/wk

Jasper is a clinical-stage biotechnology company developing briquilimab, a novel antibody targeting c-Kit (CD117) as a therapeutic for chronic mast and stem cell diseases. Jasper is currently conducting clinical studies of briquilimab as a treatment in patients with CSU or with CIndU and is initiating a clinical study in patients with asthma. Briquilimab is also currently in clinical studies as a treatment for patients with LR-MDS and as a conditioning agent for cell therapies for rare diseases. To date, briquilimab has a demonstrated efficacy and safety profile in more than 160 dosed participants and healthy volunteers, with clinical outcomes in CIndU, and as a conditioning agent in severe combined immunodeficiency (SCID), acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), Fanconi anemia (FA), and sickle cell disease (SCD).


Summary
  • Jasper is seeking a talented and motivated Translational Scientist. This role will be an integral part of the Research and Translational team, contributing to the Mast cell diseases clinical programs. This role will report to the Executive Director of Biology and Translational Research. 


Responsibilities
  • Represent translational research team at the project team meeting and serve as an interface among cross-functional teams for Mast cell diseases related clinical programs.
  • Analyze and interpret clinical biomarkers/exploratory endpoints data and contribute to bioanalytical assay development and validation
  • Present data to the cross-functional meetings and translating findings into actionable insights for therapeutic development
  • Bridge the preclinical research findings and their clinical implementation
  • Manage and oversee CROs and partners responsible for specialty lab/exploratory endpoints assessments, ensuring high-quality execution of assays and timely data reporting.
  • Contribute to clinical protocol design by selecting biomarkers, defining appropriate collection timepoints and providing robust scientific rationale
  • Identify, evaluate and initiate contracts with CROs for biomarkers, bioanalytical assays development
  • Provide scientific and technical expertise for developing Immunogenicity assays and/or other safety/efficacy assays to support the clinical programs
  • Collaborate cross-functionally with clinical development, Clinical Operations, Regulatory, Data Management to drive trials execution


Requirements
  • PhD in Immunology, Biological Sciences or a related field and 2+ years relevant post PhD experience; or MS and 6+ years’ experience; or BS and 8+ years’ experience
  • Strong experience in biomarker discovery, and translational research methodologies
  • Experience with Biologics and/or Mast cells related diseases
  • Strong ability to analyses and interpret clinical biomarkers data
  • Experience with PK/ADA or any bioanalytic assay development and validation is a plus
  • Ability to work with and oversee CRO and vendors
  • Ability to work well in a highly collaborative team environment, coordinate tasks across multiple projects to meet deadlines, and be accountable
  • Entrepreneurial and comfortable learning new skills and knowledge, and working on new projects as they arise


Jasper is an Equal Opportunity Employer and does not discriminate on the basis of race, religion, color, sex, gender identity, sexual orientation, age, non-disqualifying physical or mental disability, national origin, veteran status or any other characteristic protected by applicable law.

 

Company Values:

·       Respect

·       Collaboration

·       Integrity

·       Responsible

·       Excellence

·       Acknowledgment

 

Mission:

Our mission is to make safer and potentially curative therapy possible for more patients in need. We are bringing together a team of high performing biotech professionals, leading academic institutions and a strong syndicate of healthcare-focused investors to achieve our vision 

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What You Should Know About Senior Scientist, Translational - Onsite Contract Position - 3days/wk, Jasper Therapeutics

Jasper is on the lookout for a passionate Senior Scientist, Translational to join our innovative team in Redwood City, CA! In this exciting contract position, you will play a crucial part in our clinical studies involving briquilimab, a cutting-edge therapy aimed at addressing chronic mast and stem cell diseases. Your role will allow you to showcase your expertise in translational research while collaborating with cross-functional teams focused on our Mast cell diseases clinical programs. You’ll be responsible for analyzing clinical biomarkers and interpreting data to support the development of bioanalytical assays. If you're someone who enjoys bridging preclinical research with clinical application and thrives in a collaborative environment, this is the role for you! Reporting to the Executive Director of Biology and Translational Research, you'll also oversee CROs and partners, ensuring high-quality execution and timely reporting. Your entrepreneurial spirit and willingness to learn new skills will be essential as you contribute to our mission of creating safer, potentially curative therapies for more patients. Join us in reshaping the future of biotechnology, while being part of a values-driven team that stands for respect, collaboration, integrity, and excellence.

Frequently Asked Questions (FAQs) for Senior Scientist, Translational - Onsite Contract Position - 3days/wk Role at Jasper Therapeutics
What are the primary responsibilities of the Senior Scientist, Translational at Jasper?

As a Senior Scientist, Translational at Jasper, you will represent the translational research team at project meetings and play a vital role in our Mast cell diseases clinical programs. Key responsibilities include analyzing clinical biomarkers, developing and validating bioanalytical assays, and managing relationships with CROs to ensure high-quality data reporting. You will also contribute to clinical protocol design and support therapeutic development with actionable insights based on your research findings.

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What qualifications are required for the Senior Scientist, Translational position at Jasper?

To qualify for the Senior Scientist, Translational position at Jasper, candidates should possess a PhD in Immunology, Biological Sciences, or a related field, complemented by at least 2 years of relevant post-PhD experience. Alternatively, an MS with 6+ years of experience or a BS with 8+ years of experience is acceptable. Strong expertise in biomarker discovery, translational research methodologies, and collaborative skills are essential for success in this role.

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How does the Senior Scientist, Translational role contribute to Jasper's mission?

The Senior Scientist, Translational role at Jasper is integral to our mission of making safer, potentially curative therapies accessible to more patients. By analyzing clinical data, developing innovative assays, and facilitating communication between cross-functional teams, you will help translate groundbreaking research into effective treatments that address chronic mast and stem cell diseases, ultimately improving patient outcomes.

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What collaborative efforts are expected from the Senior Scientist, Translational at Jasper?

Collaboration is key for the Senior Scientist, Translational at Jasper. You'll work closely with clinical development, regulatory teams, and data management to ensure seamless trial execution. Sharing knowledge, insights, and working across multiple projects will be essential as you translate preclinical findings into actionable clinical strategies, making your collaborative contributions vital to our success.

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What is the workplace culture like for the Senior Scientist, Translational at Jasper?

At Jasper, the workplace culture for the Senior Scientist, Translational emphasizes respect, collaboration, integrity, and excellence. We’re a values-driven organization that encourages a supportive and inclusive environment. You’ll have the opportunity to work with high-performing biotech professionals, leading academic institutions, and a strong syndicate of investors, making this an exciting and fulfilling place to grow your career.

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Common Interview Questions for Senior Scientist, Translational - Onsite Contract Position - 3days/wk
What experience do you have in biomarker discovery relevant to the Senior Scientist, Translational role?

When answering this question, it’s important to highlight specific projects where you contributed to biomarker discovery. Discuss the methodologies you used, any successful outcomes, and how your research impacted clinical development. Show that you are familiar with current trends in translational research and how they apply to Jasper's mission.

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How do you handle oversight and management of CROs in clinical research?

In responding to this question, emphasize your leadership skills and past experiences in managing CRO relationships. Discuss specific strategies you’ve employed for ensuring that data is accurately reported and assays are executed with high quality. Stress the importance of communication and regular updates to maintain strong partnerships.

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Can you explain your experience with bioanalytical assay development?

When tackling this question, detail your familiarity with various bioanalytical techniques you have utilized. Highlight your role in the development and validation process, and any specific assays you worked on that relate to Jasper’s projects, especially in mast cell diseases. This showcases your technical comprehension and relevance to the Senior Scientist, Translational role.

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How do you approach collaborative research within cross-functional teams?

Provide examples from your past experiences where you successfully collaborated with researchers, clinical teams, or operational staff. Stress your strong communication skills and ability to share insights effectively. Describe how this collaborative approach has contributed positively to research output or project success.

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What motivates you in the field of translational research?

Focus on your passion for improving patient lives through scientific discovery. Share personal anecdotes or experiences that fueled your interest in translational research, specifically related to immunology or mast cell diseases. Convey your dedication to advancing therapies that can genuinely change patients' outcomes, tying this back to Jasper’s mission.

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Describe a challenging project you worked on in translational research.

Select a project where you faced significant obstacles but successfully overcame them through innovative solutions or teamwork. Discuss the problem, your role, the steps taken, and the outcome. This demonstrates your problem-solving abilities and adaptability, qualities essential in the Senior Scientist, Translational position.

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How do you ensure the scientific rigor of clinical protocols you contribute to?

Discuss your approach to evaluating protocols, including selecting appropriate biomarkers, defining collection timepoints, and providing scientific rationale. Mention any criteria or guidelines you follow to ensure that all aspects meet the highest standards of scientific integrity and relevance to clinical outcomes.

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What techniques do you use to analyze and interpret clinical biomarkers data?

Talk about the software or methodologies you are proficient in, such as statistical analysis methods and data visualization techniques. Provide an example of how you've successfully interpreted biomarkers data in the past and how this analysis impacted broader research goals or clinical strategies.

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How do you stay current with advancements in the field of immunology?

Emphasize the resources and networks you engage with to keep your knowledge sharp. This could include attending conferences, reading relevant journals, or collaborating with thought leaders in the field. Staying informed is critical for ensuring that your contributions remain cutting edge, benefiting your role as a Senior Scientist, Translational.

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What skills do you believe are most important for success as a Senior Scientist, Translational?

Highlight key skills such as data analysis, communication, teamwork, and problem-solving. Discuss why each is relevant to the role, citing examples of how these skills have contributed to your past successes. Tailor your answer to relate specifically to Jasper's focus on collaborative translational research.

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