Scientist I, In Vitro ADME Sciences

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok.

The Quantitative Translational and ADME Sciences (QTAS) department in AbbVie Bay Area (ABA), CA is seeking a highly motivated fulltime in vitro ADME Scientist to join the In Vitro ADME Sciences group (IVAS).  The successful candidate will work in collaboration with other team members to support preclinical characterization of drug molecules in Discovery.  The IVAS team within the QTAS department works very closely with other disciplines (bioanalysis, medicinal chemistry, pharmaceutical sciences, pharmacology, toxicology etc.) to perform preclinical compound characterization, support clinical evaluation and contribute to IND and NDA filings.

In this role, you will be a scientist with hands-on experience in conducting in-vitro ADME assays, primarily CYP450 induction to characterize candidate drug molecules for potential to induce CYP450 enzymes.  Furthermore, you will provide support to project teams to enhance mechanistic understanding of complex drug-drug interactions.

Key Accountabilities/Core Job Responsibilities:

• Routinely conduct (hands-on) evaluation of CYP450 induction of candidate molecules
• Conduct qPCR assay
• Interpretation of in vitro CYP induction data derived from assays in human hepatocytes or reporter gene systems
• Perform human hepatocytes cell culture, seeding and maintenance
• Perform cell viability assessments and use microplate reader to measure endpoint
• Contribute to other exploratory invitro ADME assay design and discussions
• Analyze data and maintain detailed, accurate and comprehensible study documentations
• Proficient in the use of Microsoft PowerPoint/Excel, BioELN and GraphPad Prism for data analysis

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• MS degree with 2 or more years of experience, B.S. with 5 or more years of experience), or equivalent in drug metabolism or related discipline with relevant industry experience in drug discovery/development. 
• Prior experience conducting ADME assays and understanding of the concept of drug-drug interaction is preferred
• Prior working experience with human hepatocytes is preferred
• Prior knowledge of molecular biology techniques such as qPCR is preferred.
• Maintain knowledge of the principles and theories in ADME in general, and CYP450 induction in particular
• Ability to clearly communicate and work collaboratively with others
• Able to independently interpret findings and present data
• The individual is expected to be proactive, organized, and passionate about ADME/drug disposition

Note: Ultimate title will depend on experience

**Equal Opportunity Employer Minorities/Women/Veterans/Disabled**

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​​

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• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.​​

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​​

• This job is eligible to participate in our short-term incentive programs. ​​

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Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. 

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion.  It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.

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