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Senior/Staff Mechanical Engineer

Synthego is a pioneering force in the biotechnology industry, dedicated to advancing the frontiers of CRISPR cell and gene therapies through cutting-edge CRISPR technology and expertise.


We are looking to add a Senior or Staff Mechanical Engineer to our hardware & research team. In this role you will design, develop, and improve proprietary hardware for Synthego’s CRISPR guide RNA manufacturing business.


This is an exciting opportunity to gain experience in chemical process automation, mechanical design, data analysis, and product development. The ideal candidate is a collaborative, detail-oriented, and creative engineer who is interested in working with a talented team to push the boundaries of oligonucleotide manufacturing. 



What You'll Do:
  • Design, prototype, and test mechanical systems involving multi-domain engineering in motion, fluidics, heat transfer, optical and electromechanical systems. 
  • Independently drive experiments according to sound engineering principles, business standards and procedures, and program requirements. Build testing set-ups, conduct experiments, analyze data, interpret results, and suggest follow-up experiments. 
  • Communicate designs and project updates through design reviews and presentations to executives, product stakeholders, and colleagues.
  • Work cross-functionally to solve problems at the intersection of hardware and software engineering, chemistry, and data science. 
  • Maintain detailed and organized documentation including design history files, qualification records, and engineering drawings. 


About You:
  • For Senior leveling: B.S./M.S. in Mechanical Engineering or related field with 3-6 years of professional experience, or PhD with relevant project experience.
  • For Staff leveling: B.S./M.S. in Mechanical Engineering or related field with 6-9 years of professional experience, or PhD with relevant project experience.
  • Demonstrated track record of building mechanical systems involving fluid handling 
  • High proficiency with 3D CAD (SolidWorks preferred)
  • Basic programming proficiency with Python or similar
  • Strong knowledge of design-for-manufacturing and GD&T principles 
  • Strong written and verbal communication skills
  • Excellent problem-solving skills
  • Able to multi-task and prioritize work effectively


Nice to Haves:
  • Demonstrated track record of building capital equipment including instruments and/or industrial automation systems in the life sciences or a similar industry (semiconductor, petrochemical, etc)
  • Experience with PLC programming
  • Experience with chemical reactor design and scaling analysis 
  • Experience with high pressure equipment, oligonucleotide synthesis, and/or analytical instrumentation
  • Knowledge of chemistry and/or previous experience working with oligonucleotides (DNA or RNA)
  • Proficiency with data analysis using Pandas/Scipy/Matplotlib or similar 
  • Machine shop experience 


Company Perks & Benefits:
  • Equity options 
  • Medical, dental, and vision benefits
  • 401k Program
  • Catered meals on Tuesday and Thursday
  • Paid parental leave
  • Flexible paid time off


$125,000 - $155,000 a year
Listed pay range covers senior through staff leveling and will be determined based on experience.

Our Mission

Synthego® is a pioneering force in the biotechnology industry, dedicated to advancing the frontiers of CRISPR cell and gene therapies through cutting-edge CRISPR technology and expertise. Our mission is to provide unparalleled access to CRISPR solutions at scale, empowering applications from Discovery to Clinic. Driven by a visionary approach, we strive to accelerate the therapeutic development process with best-in-class CRISPR solutions, simplified licensing & expert guidance, driving the adoption and success of CRISPR-based therapies to benefit all patients.

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CEO of Synthego
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Paul Dabrowski
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Average salary estimate

$140000 / YEARLY (est.)
min
max
$125000K
$155000K

If an employer mentions a salary or salary range on their job, we display it as an "Employer Estimate". If a job has no salary data, Rise displays an estimate if available.

What You Should Know About Senior/Staff Mechanical Engineer, Synthego

At Synthego, we are on the cutting edge of biotechnology, and we're looking to bring a Senior or Staff Mechanical Engineer on board to join our incredible hardware & research team in Redwood City, CA. In this pivotal role, you'll harness your mechanical engineering expertise to design, develop, and enhance proprietary hardware that plays a crucial role in our CRISPR guide RNA manufacturing business. Your creativity and collaborative spirit will thrive as you engage with a talented team, diving deep into areas like chemical process automation, mechanical design, and data analysis. You'll have the opportunity to engage in multi-domain engineering projects, where you will design, prototype, and test mechanical systems across several sophisticated domains such as motion, fluidics, and heat transfer. Not only will you conduct experiments and analyze data to drive innovative solutions, but you'll also keep our team updated through presentations to executives and stakeholders. We're especially interested in candidates with a high proficiency in 3D CAD software, ideally SolidWorks, and a solid understanding of design-for-manufacturing principles. Each day at Synthego is an opportunity to fuse your engineering prowess with groundbreaking technology, ultimately helping us to redefine the future of gene therapies for patients worldwide. If you’re ready to take your career to the next level with Synthego, we can’t wait to see the innovations you’ll bring!

Frequently Asked Questions (FAQs) for Senior/Staff Mechanical Engineer Role at Synthego
What are the responsibilities of the Senior/Staff Mechanical Engineer at Synthego?

As a Senior/Staff Mechanical Engineer at Synthego, your main responsibilities include designing, prototyping, and testing mechanical systems that integrate motion, fluidics, and heat transfer. You'll independently drive experiments, analyze data, and communicate updates through design reviews, while collaborating cross-functionally with teams in hardware, software, and chemistry disciplines.

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What qualifications are needed for the Senior/Staff Mechanical Engineer position at Synthego?

Candidates for the Senior/Staff Mechanical Engineer role at Synthego should possess a B.S./M.S. in Mechanical Engineering or a related field, with requisite professional experience (3-6 years for Senior and 6-9 years for Staff). A Ph.D. with relevant project experience is also considered. Proficiency in 3D CAD tools like SolidWorks and basic programming skills in Python are essential.

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What technical skills are important for the Senior/Staff Mechanical Engineer role at Synthego?

The Senior/Staff Mechanical Engineer at Synthego should have strong proficiency in 3D CAD software, particularly SolidWorks, a solid foundation in design-for-manufacturing principles, and experience in building mechanical systems involving fluid handling. Familiarity with data analysis tools such as Pandas or Matplotlib is a plus.

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What kind of projects will the Senior/Staff Mechanical Engineer work on at Synthego?

At Synthego, the Senior/Staff Mechanical Engineer will engage in exciting projects focused on the design and improvement of proprietary hardware for CRISPR RNA manufacturing. This includes experiments in chemical process automation and the development of innovative mechanical systems that drive our advanced biotechnology products.

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What are some nice-to-have skills for the Senior/Staff Mechanical Engineer at Synthego?

Nice-to-have skills for the Senior/Staff Mechanical Engineer position at Synthego include experience with PLC programming, knowledge of chemical reactor design, high-pressure equipment familiarity, and prior work with oligonucleotides. Experience in the life sciences, semiconductor, or petrochemical industries can also be beneficial.

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Common Interview Questions for Senior/Staff Mechanical Engineer
Can you describe your experience with 3D CAD design in relation to mechanical systems?

When answering, focus on specific projects where you utilized 3D CAD software like SolidWorks. Highlight your process for transforming concepts into detailed designs and how you ensured compliance with design-for-manufacturing principles.

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How do you approach problem-solving within cross-functional teams?

Discuss your collaborative approach, emphasizing how you engage with software engineers, chemists, and data scientists to tackle complex issues. Provide examples of past team projects that benefited from your problem-solving skills.

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What strategies do you use for conducting experiments and analyzing results?

Detail your methodology for planning experiments, including the criteria you establish for success. Explain how you analyze data and draw meaningful conclusions that inform your design decisions.

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Tell us about a mechanical system you designed that involved fluid dynamics.

Narrate a specific project where fluid dynamics was integral. Outline the challenges faced, the design process you followed, and the ultimate impact of the project on overall system performance.

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Can you explain your knowledge of design-for-manufacturing principles?

Describe your understanding of design-for-manufacturing concepts and how they influence your design decisions. Provide examples where your adherence to these principles led to improved manufacturability or cost savings.

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What role does documentation play in your engineering process?

Emphasize the importance of maintaining thorough documentation, including design history files and engineering drawings. Discuss your approach to organizing and updating these records to ensure clarity and compliance.

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How do you manage multiple projects with tight deadlines?

Discuss your prioritization skills and the tools or techniques you use to stay organized. Share specific examples of how you balanced workloads and met deadlines while ensuring high-quality results.

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What manufacturing processes are you familiar with that would apply to our industry?

Mention specific manufacturing processes relevant to the biotechnology or mechanical engineering fields, highlighting your experience with them and how you believe they could benefit Synthego's projects.

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Have you ever worked on a team where you faced significant technical challenges? How did you resolve them?

Share a story about a challenging project, focusing on the technical difficulties encountered and your contribution to finding a resolution. Highlight teamwork, innovation, and your engineering reasoning.

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What is your experience with programming and data analysis as it relates to mechanical engineering?

Explain your proficiency with programming languages like Python, focusing on how you've applied programming skills to solve engineering problems or analyze vast amounts of data for better project outcomes.

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Synthego’s vision is to turn biology into an information science, with the ultimate goal of dramatically extending the healthy human lifespan. Synthego builds advanced bioinformatics and automated hardware platforms to create next-generation mole...

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March 22, 2025

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