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Principal Associate Scientist, Gene Therapy

Job Description

  • Work independently and with cross-functional teams to perform and develop molecular assays to characterize in vivo AAV vector performance.
  • Plan and execute molecular analysis on animal tissues, including DNA/RNA isolation, RT, qPCR, and NGS library preparation.
  • Participate in process optimization independently or under limited supervision.
  • Develop in-depth knowledge in the gene therapy field.
  • Be a critical thinker familiar with the recent advancement in the focused research area and contribute to the team decision-making process.
  • Maintain complete, accurate, and timely electronic records to support internal documentation needs and regulatory submissions.
  • Manage time efficiently and contribute to multiple projects under demanding timelines.
  • Summarize results across multiple experiments in clear presentations to colleagues on the team.

May telecommute up to 20%.

Salary: $92,000/year - $129,000/year 

Qualifications

Minimum Requirements:

Employer will accept a Master’s degree, or foreign equivalent, in Molecular Biology, Plant and Environmental Sciences, Biomedical Sciences, Animal Biology, Physiology or a related field and 2 years of experience in the job offered or in a Principal Associate Scientist, Gene Therapy-related occupation.

Alternatively, employer will accept a Bachelor’s degree, or foreign equivalent, in Molecular Biology, Plant and Environmental Sciences, Biomedical Sciences, Animal Biology, Physiology or a related field and 5 years of experience in the job offered or in a Principal Associate Scientist, Gene Therapy-related occupation.

Position requires 24 months of experience in the following:

  • Extensive hands-on experience in molecular biology techniques, including DNA/RNA isolation from animal tissues, RT, qPCR, DNA gel electrophoresis, SDS-PAGE, WB.
  • Extensive hands-on experience in NGS library preparation.
  • Proficiency with analytical and presentation software, including Powerpoint, Excel, and Graphpad.
  • Excellent oral and written communication skills.
  • Works with colleagues as a team player.
  • Strong organizational and time management skills, able to advance multiple projects in parallel.
  • Proficiency in aseptic cell culture techniques.
  • Ability to design plasmid constructs and perform molecular cloning of these constructs.

Position requires demonstrable experience in the following:

Proficiency in handling AAV vectors and non-human primate tissue samples and performing molecular analysis using those samples.

Additional Information

All your information will be kept confidential according to EEO guidelines.

Why Biogen?

We are a global team with a commitment to excellence, and a pioneering spirit. As a mid-sized biotechnology company, we provide the stability and resources of a well-established business while fostering an environment where individual contributions make a significant impact. Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning, growth, and expanding their skills. Above all, we work together to deliver life-changing medicines, with every role playing a vital part in our mission. Caring Deeply. Achieving Excellence. Changing Lives.

At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds, cultures, and perspectives make us a stronger and more innovative company, and we are focused on building teams where every employee feels empowered and inspired. Read on to learn more about our DE&I efforts.

All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E-Verify Employer in the United States.

 

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Average salary estimate

$110500 / YEARLY (est.)
min
max
$92000K
$129000K

If an employer mentions a salary or salary range on their job, we display it as an "Employer Estimate". If a job has no salary data, Rise displays an estimate if available.

What You Should Know About Principal Associate Scientist, Gene Therapy, Biogen

Join Biogen as a Principal Associate Scientist in Gene Therapy, located in the vibrant city of Cambridge, MA! In this exciting role, you'll work independently and collaborate with cross-functional teams to conduct molecular assays that characterize AAV vector performance in vivo. You’ll be responsible for planning and executing molecular analyses on animal tissues, mastering techniques such as DNA and RNA isolation, RT, qPCR, and NGS library preparation. Your expertise will play a significant role in process optimization, allowing you to deepen your knowledge in this revolutionary field. As a critical thinker who is up-to-date with the latest advancements in gene therapy, your input will be invaluable in the decision-making process. You'll maintain timely and accurate electronic records to support internal documentation and regulatory submissions, while managing multiple projects efficiently under tight deadlines. Communicating your results clearly and effectively will be key during presentations to your team. With the opportunity to telecommute up to 20%, this role offers a fantastic work-life balance. Your knowledge and skills, combined with Biogen's dedication to innovation and excellence, will contribute to our mission of delivering life-changing medicines and advancing the field of gene therapy.

Frequently Asked Questions (FAQs) for Principal Associate Scientist, Gene Therapy Role at Biogen
What are the key responsibilities of a Principal Associate Scientist in Gene Therapy at Biogen?

As a Principal Associate Scientist in Gene Therapy at Biogen, you will be tasked with independently conducting molecular assays and analyzing AAV vector performance. You will plan and execute complex molecular analyses on animal tissues, engage in process optimization, and maintain accurate electronic records. Additionally, you'll be expected to summarize experimental results and participate in discussions to guide the team’s direction.

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What qualifications are needed to apply for the Principal Associate Scientist in Gene Therapy position at Biogen?

To qualify for the Principal Associate Scientist position at Biogen, you should have either a Master’s degree in a relevant field, such as Molecular Biology or Biomedical Sciences, with two years of relevant experience, or a Bachelor’s degree with five years of pertinent experience. Proficiency in molecular biology techniques, including extensive experience with DNA/RNA isolation, RT, and NGS library preparation, is also essential.

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What technical skills are important for the Principal Associate Scientist in Gene Therapy role at Biogen?

Technical skills for the Principal Associate Scientist in Gene Therapy at Biogen include extensive experience in molecular biology techniques, proficiency in NGS library preparation, and familiarity with analytical software like PowerPoint and Excel. Additionally, strong organizational skills, aseptic cell culture techniques, and the ability to design plasmid constructs are crucial for success in this role.

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How does teamwork factor into the Principal Associate Scientist in Gene Therapy position at Biogen?

Teamwork is a pivotal aspect of the Principal Associate Scientist role at Biogen. You will collaborate with cross-functional teams to make informed decisions and share insights that contribute to the collective goal of developing innovative gene therapies. Your ability to communicate effectively and work as a team player will enhance the collaborative spirit at Biogen.

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Can you explain the career growth opportunities for a Principal Associate Scientist in Gene Therapy at Biogen?

Biogen offers various career growth opportunities for a Principal Associate Scientist in Gene Therapy, including professional development workshops, project leadership roles, and potential transitions into higher managerial positions. Working at Biogen allows you to expand your skills and knowledge in a supportive atmosphere committed to innovation in biotechnology.

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Common Interview Questions for Principal Associate Scientist, Gene Therapy
Can you describe your experience with molecular biology techniques relevant to the Principal Associate Scientist role?

Be prepared to discuss specific techniques you have employed, such as DNA/RNA isolation, RT, qPCR, and NGS library preparation. Highlight successful projects where these skills were critical, emphasizing results, challenges, and what you learned.

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How do you manage multiple projects with tight deadlines in a scientific research environment?

Share examples of your time management strategies, such as prioritizing tasks, setting milestones, or using project management tools. Explain how you ensure high-quality results even under pressure.

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What role does critical thinking play in your work as a scientist?

Discuss how critical thinking influences your decision-making process. Provide examples of situations where your analytical skills led to innovative solutions or improved methodologies within your projects.

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How do you ensure your electronic records are detailed and compliant with internal and regulatory standards?

Talk about your process for documentation, emphasizing the importance of accuracy, timely updates, and familiarity with relevant regulatory requirements to support compliance.

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Tell us about a time you had to present complex scientific data to a non-scientific audience.

Focus on your ability to break down complex concepts into understandable terms. Describe how you prepared for the presentation and the feedback you received about your communication effectiveness.

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What experience do you have working with AAV vectors and animal tissue samples?

Detail your hands-on experience with AAV vectors, emphasizing any projects or studies you have conducted involving animal tissue analysis. Include specific techniques used and the outcomes achieved.

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Why do you want to work in gene therapy?

Express your passion for gene therapy and how it aligns with your career goals. Discuss any personal motivations or professional experiences that have driven your interest in this pioneering field.

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How do you stay current with advancements in gene therapy and molecular biology?

Share your methods for keeping up-to-date, such as attending conferences, subscribing to relevant journals, or participating in professional networks. Mention any impactful research or developments that have influenced your work.

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Can you provide an example of a successful collaborative project you worked on?

Choose a project that involved collaboration with interdisciplinary teams. Describe the goals, your contributions, the dynamic within the team, and the overall success of the project.

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How would you approach process optimization in your role as a Principal Associate Scientist?

Discuss your investigatory approach to identifying areas for improvement in laboratory procedures. Explain how you analyze existing processes, implement changes, and measure outcomes to ensure optimized results.

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DATE POSTED
March 22, 2025

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