Senior/Staff Engineer, Application

To qualify for the Senior/Staff Engineer, Application role at Glyphic Biotechnologies, candidates should ideally have a degree in bioengineering, biology, chemistry, or a related field, with a PhD preferred. Additionally, the role requires 6+ years of hands-on industry experience with liquid handlers and lab automation, particularly on platforms such as the Hamilton Microlab Star.

As a Senior/Staff Engineer, Application at Glyphic, you will be responsible for designing, developing, and deploying automated protein sequencing solutions, adapting protocols for various instruments, and analyzing experimental data to provide insights. You'll also work with a multidisciplinary team to enhance lab automation processes.

Key skills for the Senior/Staff Engineer, Application position include extensive experience with liquid handlers, advanced programming and data modeling skills (preferably in Python or C++), as well as experience trouble-shooting complex assay issues to drive corrective actions in a production environment.

At Glyphic, we promote continuous learning and development for our employees. As a Senior/Staff Engineer, you will have opportunities to benchmark performance against industry standards, participate in training, and contribute to a culture of knowledge sharing among your peers in our fast-paced startup environment.

Glyphic Biotechnologies offers a competitive benefits package, including 100% health plan coverage for employees and their dependents, an Employee Stock Option Plan, generous paid time off, and a supportive environment with regular team bonding activities and a focus on health and wellbeing.

When answering this question, emphasize specific liquid handling platforms you've worked with, like the Hamilton Microlab Star, and discuss the complexities you managed, including assay development and troubleshooting during protein sequencing tasks.

Outline your strategy for designing assays, focusing on scalability and optimization. Discuss your experience integrating various instruments and how you use data analysis tools to enhance throughput and efficiency in automated protocols.

Detail your proficiency with programming languages such as Python or C++. Provide examples of how you have utilized these skills to develop scripts for data handling or automate laboratory processes, highlighting any successful projects.

Give a specific example of a technical challenge you've encountered, detailing your thought process, the steps you took to diagnose and troubleshoot the problem, and the outcome or learning that resulted from your actions.

Discuss your understanding of GxP/CLIA/CAP regulations and share examples of how you've designed assays or processes to meet these standards, ensuring that your work aligns with industry regulations and best practices.

Explain your process for creating and updating Standard Operating Procedures (SOPs) and other documentation. Emphasize the importance of detailed records for maintaining quality and consistency in lab operations and compliance.

Describe what liquid class reusability entails, how it enhances efficiency and reduces errors in automated systems, and share relevant examples of how you've implemented reusable liquid classes in your past work.

Highlight your communication skills and experiences working with chemists, biologists, and engineers. Discuss methods you've used to foster collaborative environments and the importance of sharing insights and expertise across disciplines.

Share the analytical techniques and tools you use to convert complex experimental data into meaningful insights, detailing how you implement data models to inform future decision-making in project development.

Express your enthusiasm for Glyphic's mission of advancing proteome sequencing technology. Reflect on how your skills and experiences align with the company's goals, and how being a part of such an innovative organization excites you personally and professionally.